Improvement in Serum Anti-Müllerian Hormone Levels in Infertile Patients after Hyperbaric Oxygen (preliminary results)

Abstract

Objective: To assess whether hyperbaric oxygen sessions elevate serum levels of anti-Müllerian hormone (AMH) in patients diagnosed with infertility with serum levels of less than or equal to 1 ng/dl AMH. Methods: A study was performed on 4 patients diagnosed with infertility. Serum AMH level was measured at the beginning and end of hyperbaric oxygen sessions, and endometrial thickness was measured on endometrial cycle day 14 before and during the hyperbaric oxygen sessions. Results: In two of the four patients, the serum AMH level increased by 40% and 116%. In one patient the serum AMH level was not elevated, with a serum AMH level before and after treatment of 0.1 ng/dl. The fourth patient became pregnant during the hyperbaric oxygen sessions. Endometrial thickness was not improved in any of our patients. Conclusions: This study showed that hyperbaric oxygen sessions can increase serum AMH levels, with a significant increase of 116% in one case. Therefore, this therapy can be used as an alternative treatment for patients with serum AMH levels of less than or equal to 1 ng/dl and a limited number of eggs for IVF cycles but not for patients with serum AMH levels of less than or equal to 0.1 ng/dl, as we did not observe an increase in serum AMH level in patients with an initial AMH level of 0.1 ng/dl. This study did not demonstrate improvement in endometrial growth following hyperbaric oxygen sessions.

Multiple Protocols Combined with Hyperbaric Oxygen Therapy on the Maintenance of Ovarian Function in Patients After Ovarian Cystectomy

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350 years of hyperbaric medicine: historic, physiopathologic and therapeutic aspects

“…Its experimental use for the treatment of certain types of infertility has been limited so far, although it has shown promising results 86 .…”

The Efficacy of Complementary and Alternative Medicine in the Treatment of Female Infertility

“…Studies have shown that hyperbaric oxygen therapy can improve uterine hemodynamics and ER, improve ovum quality, and improve the reproductive capacity of infertile patients [ 170 , 171 ]. However, studies have shown that hyperbaric oxygen therapy did not promote endometrial thickening but increased serum AMH level, which still needs further research [ 172 ].…”