Improvement in sperm DNA quality using an oral antioxidant therapy

Tunc, Ozlem; Thompson, Jeremy G.; Tremellen, Kelton

doi:10.1016/s1472-6483(10)60024-7

Cited by 95 publications

(73 citation statements)

References 62 publications

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“…The data obtained here illustrate clearly a marked improvement in the pregnancy and implantation rates at post-treatment ICSI cycle, which is most likely mediated by enhancement in sperm DNA integrity [26] [56]. This is concurrent with the observations reported by some studies [33] [34] [46]. Showell et al [28] published the Cochrane review on the basis of meta-analysis of 34 trials that included 2876 couples evaluating the effect of oral supplementation with antioxidants for male partners of couples undergoing ART.…”

Section: Discussionsupporting

confidence: 90%

“…Basic sperm parameters in terms of volume, count and progressive motility, morphology did not change significantly following antioxidant treatment. This in agreement with Tunc et al study (Menevit) [33]. With Fertilovit ® Mplus supplementation, Wirleitner et al [32] is observed a drastic improvement in total and progressive sperm motility as well as in total sperm count in the group of oligoasthenoteratozoospermic (OAT) patients but not in the no-OAT group.…”

Section: Discussionsupporting

confidence: 88%

“…This treatment was followed by pregnancies after regular ICSI, artificial insemination or even spontaneous pregnancy. Similarly, Tunc et al [33] recorded a small but statistically significant improvement in median levels of sperm DNA protamination with a 3 months antioxidant therapy (Menevit). This medication contains zinc (25 mg) and selenium (26 µg) another important cofactor in sperm DNA protamine packaging [44] that are believed to be most likely the active ingredients responsible for the observed improvement.…”

Section: Discussionmentioning

confidence: 90%

“…Most of these studies investigated a wide variety of of antioxidants, as single agent or a 2 -4 combined antioxidants (vitamin C + E, vitamin E + selenium, vitamin E + zinc, vitamin C + E + zinc, vitamin C + E + glutathione, L-carnithine + acetylcarnitine). Unfortunately, only four trials evaluated actually the effect of a combination therapy on sperm parameters and natural pregnancies [31], on vacuolization of the sperm head according to motile sperm organelle morphology examination (MSOME) criteria [32], on sperm DNA damage [33] and on pregnancy outcomes [34] respectively.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial Effect of an Oral Antioxidant Supplementation (Fertimax2) on IVF-ICSI Outcomes: A Preliminary Clinical Study

Kacem¹,

Harzallah²,

Zedini³

et al. 2014

ARSci

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Background: Considerable evidence points towards a significant role of oxidative stress (OS) in the pathogenesis of sperm dysfunction. OS as a result of an inappropriate balance between oxidants and antioxidants in the semen can cause DNA damage and lipid peroxidation leading to failure of conception, miscarriage or potentially even childhood cancer. The objective of this study was to investigate whether a male antioxidant therapy can improve semen parameters and the results of in vitro fertilization (IVF) and intracytoplasmic sperm injection (ICSI). Methods: A total of fortyeight infertile couples were considered. Male participants were administrated Fertimax2 antioxidant treatment for at least two months prior to their partner's IVF-ICSI cycle. Sperm parameters (volume, concentration, progressive motility) and the IVF-ICSI outcomes were compared before and after the antioxidant treatment. The primary outcome measures were oocyte fertilization, cleavage and good embryo quality rates; the secondary outcomes were biochemical pregnancies, clinical pregnancies and implantation rates. Results: The principal finding that emerged from this study was that antioxidant therapy resulted in significant improvements in fertilization (p = 00.2), cleavage (p = 0.004) and good-embryo quality (p = 0.002) rates accompanied by a marked increase in clinical pregnancy (18.7% versus 2.5%) and implantation (11.8% versus 1.02%) rates. No significant changes in routine sperm parameters were observed. Conclusion: The Fertimax2 antioxidant therapy appears to influence favorably chances of conception in couples undergoing assisted reproduction treatment (ART).

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Section: Discussionsupporting

confidence: 90%

Section: Discussionsupporting

confidence: 88%

Section: Discussionmentioning

confidence: 90%

Section: Introductionmentioning

confidence: 99%

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Beneficial Effect of an Oral Antioxidant Supplementation (Fertimax2) on IVF-ICSI Outcomes: A Preliminary Clinical Study

Kacem¹,

Harzallah²,

Zedini³

et al. 2014

ARSci

View full text Add to dashboard Cite

show abstract

“…This is aligned with others' findings whereby approximately 15% of infertile men tested have semen within normal parameters [9,10]. Table 5 shows that a higher proportion of semen samples with normal sperm concentrations according to the 5th Edition but abnormalities of sperm Men producing samples with abnormal DFLs may therefore approach assisted reproduction with a number of different strategies to help achieve a pregnancy, including the use of antioxidants [29], ICSI [16] or frequent ejaculation [30].…”

Section: Discussionsupporting

confidence: 83%