Improvement in Streptomycin-Producing Strains of Streptomyces Griseus by Ultraviolet and X-Ray Energy

Savage, George

doi:10.1128/jb.57.4.429-441.1949

Cited by 20 publications

(12 citation statements)

References 13 publications

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“…Forty-seven kr resulted in 1 per cent survivors (figure 1). One-third of this dose has been reported as producing the same mortality in S. flaveolus (Kelner, 1948) and one-eighteenth of this dose in the case of S. griseus (Savage, 1949).…”

Section: Discussionmentioning

confidence: 81%

MUTANTS RECOVERED AFTER EXPOSURE OF STREPTOMYCES VENEZUELAE TO X-RAYS

Gwatkin

Gottlieb

1956

J Bacteriol

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There have been relatively few studies of induced mutations in actinomycetes when compared with certain bacteria and fungi. Most of these studies (Dulaney et at., 1949; Katagiri, 1954; Okami and Umezawa, 1950; Okami et al., 1950; Savage, 1949) were concerned primarily with obtaining strains with enhanced antibiotic production, although a few (Appleby, 1948; Kelner, 1948; Newcombe, 1953) dealt with other types of mutants. None of these studies included Streptomyces vnezuelae, the actinomycete which produces chloramphenicol. Our study on the irradiation of spores of this species with X-rays was aimed at (1) determination of the relationship between dosage and the survival of this organism and a quantitative estimation of the most readily detected mutants at various dosages and (2) isolation of mutants with blocks in 3 Vatsol is a detergent produced by American Cyanamid Co., Agricultural Division.

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Section: Discussionmentioning

confidence: 81%

MUTANTS RECOVERED AFTER EXPOSURE OF STREPTOMYCES VENEZUELAE TO X-RAYS

Gwatkin

Gottlieb

1956

J Bacteriol

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“…The evidence, at the present time, is altogether too meager to justify or refute the hypothesis. I strongly support Erikson (1947 and1949) in his view that this problem is of major importance and "that in a discussion of variation, such as the frequent phenomenon of asporogenous sectors produced within a single colony, it is essential to consider the origin of the inoculum in every instance." Let us examine some of the reported observations that relate to the twophase life-cycle concept.…”

mentioning

confidence: 84%

“…It is well known that the rate of mutation can be increased by certain agents such as X radiation, ultraviolet radiation, and by nitrogen mustard (C1 CH2 CH2)zN. See, for example, Savage (1949), Dulaney, Kuger, and Hlavac (1949), and Pittenger and McCoy (1953). This finding has naturally been followed with particular interest by workers intending to exploit mutants that are profitable antibiotic or vitamin producers.…”

Section: Comments On Observations Of Vuriability In Streptomycesmentioning

confidence: 99%

VARIATION IN STREPTOMYCES

Jones

1954

Annals of the New York Academy of Sciences

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“…Jensen has shown (188) thatunder the influence of ultraviolet rays or even spontaneously, two strains of Nocardia isolated from Australian soils gave rise to new forms, some of which resembled t\'pical species of Streptowyces and others of which were closer to the mvcobacteria. Jensen (191) also observed that under the influence of LiCl mycobacteria gave rise to forms that might be con- Savage (385) reported that ultraviolet rays were less mutagenic than the x-ravs, the harder rays of 0.710A and 0.210A wave lengths being most efficient. Mutation rates increased with killing rates up to 99.9 per cent of killing.…”

Section: Types Of Variation:-mentioning

confidence: 99%