Improvement in the gelling properties of myofibrillar protein from the razor clam (Sinonovacula constricta) through phosphorylation and structural characterization of the modified protein

Zhang, Qing; Hou, Yakun; Liu, Xiaohan; Sun, Jilu; Wang, Xianghong; Sang, Yaxin

doi:10.1016/j.fochx.2023.101006

Cited by 4 publications

(1 citation statement)

References 34 publications

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“…The muscle of MC is rich in protein, multivitamins, and nutrients needed by the human body. Studies have shown that the compounds found in MC, such as proteins and glycine, may have protective effects on the liver [22,23]. Furthermore, because MC is a strong source of bioactive peptides, it shows promise in preventing alcohol-induced liver damage.…”

Section: Introductionmentioning

confidence: 99%

Effects of Mactra chinenesis Peptides on Alcohol-Induced Acute Liver Injury and Intestinal Flora in Mice

Wu,

Cheng,

et al. 2024

Foods

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Food-borne bioactive peptides have shown promise in preventing and mitigating alcohol-induced liver injury. This study was the first to assess the novel properties of Mactra chinenesis peptides (MCPs) in mitigating acute alcoholic liver injury in mice, and further elucidated the underlying mechanisms associated with this effect. The results showed that MCPs can improve lipid metabolism by modulating the AMPK signaling pathway, decreasing fatty acid synthase activity, and increasing carnitine palmitoyltransferase 1a activity. Meanwhile, MCPs ameliorate inflammation by inhibiting the NF-κB activation, leading to reduced levels of pro-inflammatory cytokines (tumor necrosis factor-α and interleukin-1β). Additionally, a 16S rDNA sequencing analysis revealed that MCPs can restore the balance of gut microbiota and increase the relative abundance of beneficial bacteria. These findings suggest that supplementation of MCPs could attenuate alcohol intake-induced acute liver injury, and, thus, may be utilized as a functional dietary supplement for the successful treatment and prevention of acute liver injury.

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Section: Introductionmentioning

confidence: 99%