Improvement in the healing of bone fractures using a cyclodextrin/Ni-MOF nanofibers network: the development of a novel substrate to increase the surface area with desirable functional properties

Abstract

In this study, we describe a β-cyclodextrins (β-CDs)/Ni-based MOF (β-CDs/Ni-based MOF) network for orthopedic applications.

Application of metal-organic frameworks-based functional composite scaffolds in tissue engineering

“…In solution mixing or solution blending, MOFs particles and matrix materials are mixed in solution, and the nanoparticles are evenly dispersed in solution by stirring or ultrasonic dispersion. The blended solution can be used for the direct preparation of hydrogels [ 63 , 66 ], electrospinning fibers [ 38 , 67–69 ], 3D printing scaffolds [ 70–72 ] or mold casting scaffolds [ 73 , 74 ] ( Figure 1B ).…”

“…However, although these materials have good biocompatibility and present their own advantages in practical applications, their low osteogenic induction ability, insufficient vascularization and lack of anti-inflammatory effects ultimately lead to poor bone injury repair. MOFs have been widely studied in the field of bone regeneration due to their proangiogenic, anti-inflammatory and drug loading functions [ 52 , 67 , 164 , 165 ]. ZIF-8-modified multifunctional hydrogels were designed to stabilize the bone graft environment, ensure blood supply, promote osteogenic differentiation and accelerate bone remodeling [ 134 ].…”