Improvement in the measurement error of the specific binding ratio in dopamine transporter SPECT imaging due to exclusion of the cerebrospinal fluid fraction using the threshold of voxel RI count

Mizumura, Sunao; Nishikawa, Kazuhiro; Murata, Akira; Yoshimura, Kosei; Ishii, N.; Morooka, Miyako; Kajiyama, Akiko; Terahara, Atsuro

doi:10.1007/s12149-018-1249-9

Cited by 19 publications

(19 citation statements)

References 9 publications

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“…The CSF-mask algorithm has been developed to reduce the influence of CSF-low-counts [8]. In this algorithm, threshold process that removes the CSF-low-counts within the reference VOI is applied.…”

Section: Discussionmentioning

confidence: 99%

“…In the CSF-mask algorithm, the threshold is defined as follows: where and σ are the median and standard deviation, respectively, of the background histogram with a Gaussian fit normal distribution and k is a coefficient. Previous reports informed our use of 1.0 as the k value [8, 10].…”

Section: Methodsmentioning

confidence: 99%

“…One disadvantage is that the striatal VOI cannot be divided into the caudate nucleus and the putamen; thus, the diagnostic performance is not superior compared to the VOI settings where the striatal VOI is divided. Another disadvantage is that it is marred by SBR index fluctuations in cases of brain atrophy or cerebral ventricle dilatation because the low-count areas caused by cerebrospinal fluid (CSF) have negative influences on both the striatal and reference VOI counts [8–10]. Also, Furuta et al previously demonstrated the impact of ventricular enlargement on the SBR index with a three-dimensional (3D)-striatum digital brain phantom [10].…”

Section: Introductionmentioning

confidence: 99%

“…Recently, the CSF-mask algorithm has been developed to reduce the aforementioned influence of CSF-low-counts [8]. Camicioli et al reported that ventricular dilatation occurs early in the course of significant cognitive decline in patients with PD, and possibly reflect losses of both gray and white matter.…”

Section: Introductionmentioning

confidence: 99%

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Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of 123I-Ioflupane SPECT: an investigation of parkinsonian syndromes

et al. 2019

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Background A cerebrospinal fluid (CSF)-mask algorithm has been developed to reduce the adverse influence of CSF-low-counts on the diagnostic utility of the specific binding ratio (SBR) index calculated with Southampton method. We assessed the effect of the CSF-mask algorithm on the diagnostic performance of the SBR index for parkinsonian syndromes (PS), including Parkinson’s disease, and the influence of cerebral ventricle dilatation on the CSF-mask algorithm. Methods We enrolled 163 and 158 patients with and without PS, respectively. Both the conventional SBR (non-CSF-mask) and SBR corrected with the CSF-mask algorithm (CSF-mask) were calculated from 123 I-Ioflupane single-photon emission computed tomography (SPECT) images of these patients. We compared the diagnostic performance of the corresponding indices and evaluated whether the effect of the CSF-mask algorithm varied according to the extent of ventricle dilatation, as assessed with the Evans index (EI). A receiver-operating characteristics (ROC) analysis was used for statistical analyses. Results ROC analyses demonstrated that the CSF-mask algorithm performed better than the non-CSF-mask (no correction, area under the curve [AUC] = 0.917 [95% confidence interval (CI) 0.887–0.947] vs. 0.895 [95% CI 0.861–0.929], p < 0.001; attenuation correction, AUC = 0.930 [95% CI 0.902–0.957] vs. 0.903 [95% CI 0.870–0.936], p < 0.001). When not corrected for attenuation, no significant difference in the AUC was observed in the low EI group between the non-CSF-mask and CSF-mask algorithms (0.927 [95% CI 0.877–0.978] vs. 0.942 [95% CI 0.898–0.986], p = 0.11); in the middle and high EI groups, the CSF-mask algorithm performed better than the non-CSF-mask algorithm (middle EI group, AUC = 0.894 [95% CI 0.825–0.963] vs. 0.872 [95% CI 0.798–0.947], p < 0.05; high EI group, AUC = 0.931 [95% CI 0.883–0.978] vs. 0.900 [95% CI 0.840–0.961], p < 0.01). When corrected for attenuation, significant differences in the AUC were observed in all three EI groups (low EI group, AUC = 0.961 [95% CI 0.924–0.998] vs. 0.942 [95% CI 0.895–0.988], p < 0.05; middle EI group, AUC = 0.905 [95% CI 0.843–0.968] vs. 0.872 [95% CI 0.800–0.944], p < 0.005; high EI group, AUC = 0.954 [95% CI 0.917–0.991] vs. 0.917 [95% CI 0.862–0.973], p < 0.005). Conclusion The CSF-mask algorithm improved the performance of the SBR index in informing the diagnosis of PS, especially in cases with ventricle dilatation.

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Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of 123I-Ioflupane SPECT: an investigation of parkinsonian syndromes

et al. 2019

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“…The method seems to be very practical and reasonable to place a VOI on the striatum. Recently, a new correction method for SBR Bolt calculation was introduced to avoid PVE from very low counts of the CSF space [ 21 ]. The method would reduce the influence of brain atrophy and infarction; however, it cannot avoid the effects of spillover as well as different size of individual V voi which induces variation of the constant R .…”

Section: Discussionmentioning

confidence: 99%

Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis

et al. 2018

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ObjectiveTo calculate the specific binding ratio (SBR) appropriately in dopamine transporter (DAT) imaging, a method for extracting the striatal volume of interest (VOI) was developed.MethodsThis study included 200 patients (72 ± 10 years) who were suspected of parkinsonian syndromes (PS) or dementia with Lewy body (DLB). The patients were divided into three groups of PS with dopaminergic degeneration, DLB and non-PS after [123I]ioflupane (FP-CIT) SPECT and clinical follow-up. The image data were reconstructed with CT attenuation correction and scatter correction, and with only CT attenuation correction (CTAC). The new method extracted striatal VOI according to the high-level counts and the average striatum volume, and calculated SBR using the reference occipital counts. The SBR values for each patient were obtained using the Tossici-Bolt method (SBRBolt) and our method. Reproducibility of SBR calculation using our method was compared by two operators.ResultsThe mean SBR values for the PS and DLB groups were significantly different from that of the non-PS group with both methods. The coefficients of variation of the SBR were significantly smaller with the proposed method compared with those of SBRBolt (p < 0.001), except for the CTAC images. There were no differences in SBR between the two operators using our method. The diagnostic accuracies with our method for the PS and DLB groups were 98.4 and 96.0%, respectively.ConclusionOur new method for SBR calculation in the FP-CIT SPECT showed less coefficients of variation with high reproducibility, which would be useful for clinical diagnosis and in assessing the severity of diseases in follow-up studies.

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The eagle-wing finding in FP-CIT SPECT, as a characteristic finding in patients with DESH- type iNPH

Miyazaki,

Yamada,

Kaida

et al. 2024

Neuroradiology

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Improvement in the measurement error of the specific binding ratio in dopamine transporter SPECT imaging due to exclusion of the cerebrospinal fluid fraction using the threshold of voxel RI count

Abstract: The SBR calculated using the threshold method was highly correlated with the MRI-SBR. These results suggest that the CSF correction of the threshold method is effective for the calculation of idealized SBR and AI values.

Cited by 19 publications

References 9 publications

Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of 123I-Ioflupane SPECT: an investigation of parkinsonian syndromes

Impact of the cerebrospinal fluid-mask algorithm on the diagnostic performance of 123I-Ioflupane SPECT: an investigation of parkinsonian syndromes

Count-based method for specific binding ratio calculation in [I-123]FP-CIT SPECT analysis

The eagle-wing finding in FP-CIT SPECT, as a characteristic finding in patients with DESH- type iNPH

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