Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Schrepf, Andrew; Harte, Steven E.; Miller, Nicole; Fowler, Christine; Nay, Catherine; Williams, David A.; Clauw, Daniel J.; Rothberg, Amy E.

doi:10.1016/j.jpain.2017.08.004

Cited by 34 publications

(34 citation statements)

References 48 publications

(48 reference statements)

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“…For example, although a 3% to 5% loss of initial weight has generally been accepted as being clinically significant, 11,53 recent research shows that greater weight losses, ie, of 7.7%, 10%, 15%, or 20%, dose-dependently improve health outcomes. 54,55,56,57 In addition, if treated effectively, the costs of obesity-related health complications would be significantly reduced. 2 Thus, implementing effective obesity treatments is essential to reducing obesity-related comorbidities and the associated costs.…”

Section: Discussionmentioning

confidence: 99%

Effect of Weight Loss via Severe vs Moderate Energy Restriction on Lean Mass and Body Composition Among Postmenopausal Women With Obesity

et al. 2019

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Key PointsQuestionWhat are the long-term effects of severe vs moderate energy restriction on lean mass and other aspects of body composition?FindingsThis randomized clinical trial included 101 postmenopausal women with obesity. At 12 months, participants who had undergone severe energy restriction experienced approximately 2-fold greater weight and fat loss, approximately 1.5 times as much loss of whole-body lean mass (proportional to total weight lost), and approximately 2.5 times as much loss of total hip bone mineral density compared with participants who had undergone moderate energy restriction.MeaningAlthough severe energy restriction is an effective obesity treatment, caution is necessary when implementing it in postmenopausal women, especially those with osteopenia or osteoporosis.

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Section: Discussionmentioning

confidence: 99%

Effect of Weight Loss via Severe vs Moderate Energy Restriction on Lean Mass and Body Composition Among Postmenopausal Women With Obesity

et al. 2019

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“…So, it should be highlighted that it can be influence on results. Moreover, additional information about the participants is lacking, such as history of physical/mental diseases, medication use, the weight change in the last year/months and it is known from other studies that these variables may have an impact on the eating behaviours and body-related behaviours [ 68 – 70 ]. Furthermore, the limitations are associated also with the kind of data, which was self-reported data.…”

Section: Discussionmentioning

confidence: 99%

Food-related behaviours among individuals with overweight/obesity and normal body weight

Brytek-Matera

Czepczor-Bernat

Olejniczak

2018

Nutr J

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BackgroundEmotional eating is a factor associated with a negative body image and other problematic eating behaviours. In this context little is known about differences between individuals with overweight and obesity and those with normal body weight. The main aim of the study was to evaluate the role of emotional eating in the relationship between the desire to consume chocolate and the wish to avoid social situations related to food and body exposures. For this purpose, we tested the direct, indirect and buffer effects. In addition, we used moderated mediation by introducing snacking into the model.MethodsThe study included 123 outpatients with excessive body weight and 123 individuals with normal weight. The mean of body mass index (BMI) in the first group was 30.19 kg/m2 (SD = 4.37) and, in the second, it was 23.02 kg/m2 (SD = 1.20). The Three-Factor Eating Questionnaire, the Attitudes to Chocolate Questionnaire and the Body Image Avoidance Questionnaire were used.ResultsResults show that in all individuals, the greater emotional eating is, the greater the desire for chocolate consumption and avoidance of social situations related to food and body exposures are. In addition, the desire for chocolate consumption are positively associated with avoidance of social situations related to food and body exposures in both group. Among individuals with excessive and normal body weight, emotional eating is a significant mediator in the relationship between desire for chocolate consumption and avoidance of social situations related to food and body exposures. However, it does not moderate the relationship between these variables. Outcomes show that there is a significant model of moderated mediation of the link between social situation–avoidance related to food and body exposure and the desire to consume chocolate through emotional eating, moderated by snacking among individuals with normal body weight. A similar effect has not been discovered in the group with excessive body weight.ConclusionThe presented results show that among people with varied BMI categories, emotional eating is connected to craving chocolate and avoidance of social situations related to food and body exposure that plays only the role of mediation. In addition, snacking is crucial for this relationship among the group with normal body weight.

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“…In other conditions closely linked to FM, such as interstitial cystitis, more sensitive assays of immune system function, that can be gleaned by stimulating peripheral immune cells, have been shown to be abnormal (Schrepf et al., ). We and others have speculated that diet or obesity could contribute to this low‐grade inflammation in FM, and might be a potential target for therapy (Schrepf et al., ); while others have posited that this may provide evidence of microglia involvement in FM. These areas warrant further exploration, and are actively being investigated.…”

Section: Features Of Central Sensitizationmentioning

confidence: 97%

The neurobiology of central sensitization

Harte

Harris

Clauw

2018

J Appl Biobehavioral Res

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263

274

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Central sensitization refers to the amplification of pain by central nervous system mechanisms. Classically described as a consequence of ongoing nociceptive input, it is increasingly recognized that central sensitization also occurs independent of peripheral injury or inflammation. Features of central sensitization have been identified in nearly all chronic pain conditions, and it is considered the primary underlying cause of pain in conditions such as fibromyalgia. Central sensitization is characterized in these conditions by widespread pain and multisite hyperalgesia/ allodynia. Co-occurring symptoms include fatigue, mood and cognitive problems, sleep disturbances, and multisensory hypersensitivity. Individuals with central sensitization often report previous exposure to psychosocial or physical stressors, and a higher personal lifetime and family history of pain, with the latter findings supported by genetic studies. Neuroimaging studies of central sensitization show evidence of: changes in brain gray matter in pain processing regions; neurochemical imbalances; and altered resting brain-network connectivity between pronociceptive and antinociceptive brain areas. Immune system abnormalities have also been demonstrated in individuals with central sensitization. The recognition of central sensitization, andwhether it is being driven by ongoing nociceptive input or it is occurring in the absence of a peripheral driver, is critical for effective pain management.

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Improvement in the Spatial Distribution of Pain, Somatic Symptoms, and Depression After a Weight Loss Intervention

Cited by 34 publications

References 48 publications

Effect of Weight Loss via Severe vs Moderate Energy Restriction on Lean Mass and Body Composition Among Postmenopausal Women With Obesity

Effect of Weight Loss via Severe vs Moderate Energy Restriction on Lean Mass and Body Composition Among Postmenopausal Women With Obesity

Food-related behaviours among individuals with overweight/obesity and normal body weight

The neurobiology of central sensitization

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