Improvement of acute cadmium toxicity by pretreatment with copper salt

Li, D.; Katakura, Michihiro; Sakata, Naoki

doi:10.1007/bf00197973

Cited by 5 publications

(3 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Pre-exposure or co-exposure to other elements such as copper, selenium, zinc, and manganese has a protective effect on Cd toxicity. For copper, the protective effect of co-exposure to Cd has been shown, for example, in mice [ 151 ]. However, the cellular mechanism behind this effect remains unknown.…”

Section: Resultsmentioning

confidence: 99%

Cadmium Protection Strategies—A Hidden Trade-Off?

Sandbichler

Höckner

2016

IJMS

View full text Add to dashboard Cite

Cadmium (Cd) is a non-essential transition metal which is introduced into the biosphere by various anthropogenic activities. Environmental pollution with Cd poses a major health risk and Cd toxicity has been extensively researched over the past decades. This review aims at changing the perspective by discussing protection mechanisms available to counteract a Cd insult. Antioxidants, induction of antioxidant enzymes, and complexation of Cd to glutathione (GSH) and metallothionein (MT) are the most potent protective measures to cope with Cd-induced oxidative stress. Furthermore, protection mechanisms include prevention of endoplasmic reticulum (ER) stress, mitophagy and metabolic stress, as well as expression of chaperones. Pre-exposure to Cd itself, or co-exposure to other metals or trace elements can improve viability under Cd exposure and cells have means to reduce Cd uptake and improve Cd removal. Finally, environmental factors have negative or positive effects on Cd toxicity. Most protection mechanisms aim at preventing cellular damage. However, this might not be possible without trade-offs like an increased risk of carcinogenesis.

show abstract

Section: Resultsmentioning

confidence: 99%

Cadmium Protection Strategies—A Hidden Trade-Off?

Sandbichler

Höckner

2016

IJMS

View full text Add to dashboard Cite

show abstract

“…Chloride cells proliferation has been observed in gills of specimens of D. labrax exposed to cadmium [113]. Moreover, cadmium inhibits calcium uptake in gills [114] and may alter the metabolism of essential trace element by affecting normal tissue distribution of trace elements as Zn and Cu [115]. Omer et al [116] reported histopathological alterations in liver, intestine and kidneys of tilapia fish (Oreochromis niloticus) exposed to cadmium.…”

Section: Arsenic (As)mentioning

confidence: 99%

Use of Fish as Bio-indicator of the Effects of Heavy Metals Pollution

Authman¹,

Zaki²,

Khallaf³

et al. 2015

J Aquac Res Development

396

226

View full text Add to dashboard Cite

The present review gives a brief account of the toxic effects of heavy metals on fish. In aquatic ecosystem, heavy metals are considered as the most important pollutants, since they are present throughout the ecosystem and are detectable in critical amounts. Heavy metals, such as mercury, cadmium, copper, lead and zinc are of the most important pollutants which effect aquatic environment and fish. They are extremely dangerous for the health of fish. Most of these metals are characterized by being accumulated in tissues, and lead to the poisoning of fish. These metals can effectively influence the vital operations and reproduction of fish; weaken the immune system, and induce pathological changes. As such, fish are used as bio-indictors, playing an important role in monitoring heavy metals pollution. Finally, some recommendations are given to treatment of different kinds of wastewaters, sewage and agricultural wastes before discharge into the aquatic systems. Also, enforcement of laws and legislations regarding the protection of aquatic environments must be taken into consideration.

show abstract

“…The major Hg toxicity occurred due to the organic form of methylmercury (MeHg + ) 96 and estimated that 70 to 100% of the Hg in fish is present as MeHg + . The methylmercury has created pollution in Minimata Bay, Japan 102 . The liver is a prime organ for binding, storage, and redistribution of Hg in fish tissues 103 .…”

Section: Discussionmentioning

confidence: 99%

Health risk assessment and metal contamination in fish, water and soil sediments in the East Kolkata Wetlands, India, Ramsar site

Kumar

Chandan

Bhushan

et al. 2023

Sci Rep

View full text Add to dashboard Cite

East Kolkata Wetlands (EKW) is an important site for fish culture in sewage-fed areas, which are major receivers of pollutants and wastages from Kolkata. EKW is internationally important as the Ramsar site was declared on Aug 2002 with an area of 125 km2. EKW is a natural water body where wastewater-fed natural aquaculture has been practiced for more than 70 years. It is ecologically vulnerable due to the discharge of toxic waste through sewage canals from cities. Assessing the EKW to understand the inflow and load of the toxic metal (s) in fish, water, and sediments samples is essential. The field (samples collection from 13 sites) and lab (determination of toxic level of metals) based research were carried out to assess metal toxicity and health risk assessment in EKW. The levels of eighteen metals (18), namely Chromium, Vanadium, Cobalt, Manganese, Copper, Nickel, Zinc, Silver, Molybdenum, Arsenic, Selenium, Tin, Gallium, Germanium, Strontium, Cadmium, Mercury, and Lead, were determined using Inductively coupled plasma mass spectrometry (ICP-MS) in five fish tissues viz. muscle, liver, kidney, gill and brain, along with the water samples and soil sediments in 13 sampling sites. The bioaccumulation and concentration of metals in fish tissues, soil sediments, and water samples were well within the safe level concerning the recommendation of different national and international agencies except for a few metals in a few sampling sites like Cd, As, and Pb. The geoaccumulation index (Igeo) was also determined in the soil sediments, indicating moderate arsenic, selenium, and mercury contamination in a few sites. The contamination index in water was also determined in 13 sampling sites. The estimated daily intake (EDI), reference dose (RfD), target hazard quotient (THQ), slope factor and cancer risk of Cr, Mn, Co, Ni, Cu, Zn, As, Se, Cd, Pb and Hg from fish muscle were determined. Based on the results of the present investigation, it is concluded that fish consumption in the East Kolkata Wetland (EKW) is safe. The effects of bioaccumulation of metals in muscle tissue were well within the safe level for consumption as recommended by WHO/FAO.

show abstract

Improvement of acute cadmium toxicity by pretreatment with copper salt

Cited by 5 publications

References 12 publications

Cadmium Protection Strategies—A Hidden Trade-Off?

Cadmium Protection Strategies—A Hidden Trade-Off?

Use of Fish as Bio-indicator of the Effects of Heavy Metals Pollution

Health risk assessment and metal contamination in fish, water and soil sediments in the East Kolkata Wetlands, India, Ramsar site

Contact Info

Product

Resources

About