Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison’s disease

Giordano, Roberta; Guaraldi, Federica; Marinazzo, Elisa; Fumarola, Federica; Rampino, Alessia; Berardelli, Rita; Karamouzis, Ioannis; Lucchiari, Manuela; Manetta, Tilde; Mengozzi, Giulio; Arvat, Emanuela; Ghigo, Ezio

doi:10.1007/s12020-015-0681-z

Cited by 84 publications

(106 citation statements)

References 31 publications

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“…In addition, positive changes were also evident in a three-week walking programme reported in the study of GoldhaberFiebert et al although insignificantly small. 48,49 The percentage decline in LDL-C (11.9%) observed in this study is greater than the value in the meta-analysis conducted by Kelly and Kelly which indicated a significant reduction by 5% for LDL-C. 50 The improvement in TC, T, HDL-C-C and LDL-C exhibits clear evidence of reduction in atherogenic traits of risk factors 51,52 and better quality of life [53][54][55] of the sample studied. Authors observed that there are variations in the findings associated with this study in literature which are attributed to intensity, duration and frequency of exercise trainings and sample sizes.…”

Section: Discussioncontrasting

confidence: 54%

Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Asuako¹,

Moses²,

Eghan³

et al. 2017

Ghana Medical Journal

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Section: Discussioncontrasting

confidence: 54%

Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Asuako¹,

Moses²,

Eghan³

et al. 2017

Ghana Medical Journal

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“…In addition, advantages other than patient convenience have not been robustly demonstrated to date. However, data are steadily accumulating to support improved metabolic outcomes 31,32 and the use of Plenadren® is likely to increase. An additional product, Chronocort®, containing microparticulate hydrocortisone with delayed absorption, is also currently in development.…”

Section: New Developmentsmentioning

confidence: 99%

Adrenal insufficiency – recognition and management

Pazderska

Pearce

2017

Clinical Medicine

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Adrenal insuffi ciency is characterised by inadequate glucocorticoid production owing to destruction of the adrenal cortex or lack of adrenocorticotropic hormone stimulation. In primary adrenal insuffi ciency, lack of mineralocorticoids is also a feature. Patients can present with an insidious onset of symptoms, or acutely in adrenal crisis, which requires prompt recognition and treatment. Chronic glucocorticoid therapy is the most common cause of adrenal insuffi ciency. The diagnosis of adrenal insuffi ciency is made by demonstrating low basal and/or stimulated serum cortisol and should be followed by appropriate investigations to establish the underlying aetiology. Maintenance glucocorticoid replacement is usually given as a twice or thrice daily hydrocortisone preparation. Patients with primary adrenal insuffi ciency also require mineralocorticoid. Regular monitoring for features of underand over-replacement is essential during follow-up. Patient education is a key feature of management of this condition. IntroductionThe adrenal cortex secretes the essential steroid hormones, cortisol and aldosterone, under the control of pituitary adrenocorticotropic hormone (ACTH), angiotensin II and plasma potassium. The most frequent cause of adrenal insufficiency is exogenous steroid use. Up to 2.5% of the population are taking such steroid medications for inflammatory or immune-mediated conditions. 1 These individuals are vulnerable to steroid deficiency if the medication is stopped suddenly. ACTH deficiency (secondary adrenal insufficiency) as a result of pituitary tumours, infiltrative diseases, head injury or congenital hypopituitarism is the next most frequent cause, present in around 1 per 3,000 individuals. 2High dose opiates, which frequently induce hypogonadotropic hypogonadism, are also increasingly recognised as a cause of hypothalamic-pituitary-adrenal (HPA) suppression.3 By comparison, primary adrenal insufficiency is rare, with a prevalence of 1 in 8,000 people. 4 In developed nations, an autoimmune attack directed against the adrenal steroidogenic enzymes (predominantly 21-hydroxylase) 5 accounts for about 85% of cases. Around 60% of patients with autoimmune ABSTRACT Adrenal insuffi ciency -recognition and managementAddison's disease have an additional autoimmune condition, most frequently autoimmune thyroid disease or type 1 diabetes.

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“…Recently, the disease-specific questionnaire AddiQoL was developed (40) and validated (41) as an evaluative tool in PAI, which might facilitate the detection of minor changes in well-being in future clinical trials and during routine follow-up of patients (42,43,44,45).…”

Section: Health-related Quality Of Lifementioning

confidence: 99%

MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review

Bensing

Hulting

Husebye

et al. 2016

European Journal of Endocrinology

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In this article, we review published studies covering epidemiology, natural course and mortality in primary adrenal insufficiency (PAI) or Addison's disease. Autoimmune PAI is a rare disease with a prevalence of 100-220 per million inhabitants. It occurs as part of an autoimmune polyendocrine syndrome in more than half of the cases. The patients experience impaired quality of life, reduced parity and increased risk of preterm delivery. Following a conventional glucocorticoid replacement regimen leads to a reduction in bone mineral density and an increase in the prevalence of fractures. Registry studies indicate increased mortality, especially evident in patients diagnosed with PAI at a young age and in patients with the rare disease autoimmune polyendocrine syndrome type-1. Most notably, unnecessary deaths still occur because of adrenal crises. All these data imply the need to improve the therapy and care of patients with PAI.

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Improvement of anthropometric and metabolic parameters, and quality of life following treatment with dual-release hydrocortisone in patients with Addison’s disease

Cited by 84 publications

References 31 publications

Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Fasting plasma glucose and lipid profiles of diabetic patients improve with aerobic exercise training

Adrenal insufficiency – recognition and management

MANAGEMENT OF ENDOCRINE DISEASE: Epidemiology, quality of life and complications of primary adrenal insufficiency: a review

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