Improvement of antibacterial activity of copper nanoclusters for selective inhibition on the growth of gram-positive bacteria

Xia, Junmei; Wang, Wenjing; Hai, Xin; Shuang, E; Shu, Yang; Wang, Jianhua

doi:10.1016/j.cclet.2018.07.008

Cited by 49 publications

(36 citation statements)

References 35 publications

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“…Apart from tackling cancer, Cu NCs display antibacterial effects. This has been illustrated by the case of tannic acid‐capped Cu NCs ( Figure ) . After incubation with these NCs for 10 min, the growth of Staphylococcus aureus and Bacillus subtilis was found to be completely inhibited .…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 81%

“…This has been illustrated by the case of tannic acid‐capped Cu NCs ( Figure ) . After incubation with these NCs for 10 min, the growth of Staphylococcus aureus and Bacillus subtilis was found to be completely inhibited . The cellular integrity of those treated Gram‐positive bacteria was drastically lost, leading to cell rupture and a substantial change in the morphology of the bacterial cells .…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 93%

“…After incubation with these NCs for 10 min, the growth of Staphylococcus aureus and Bacillus subtilis was found to be completely inhibited . The cellular integrity of those treated Gram‐positive bacteria was drastically lost, leading to cell rupture and a substantial change in the morphology of the bacterial cells . The same cell treatment, however, showed little effect on the growth of Gram‐negative bacteria (including Escherichia coli O157:H7 and Pseudomonas aeruginosa ) .…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

“…The cellular integrity of those treated Gram‐positive bacteria was drastically lost, leading to cell rupture and a substantial change in the morphology of the bacterial cells . The same cell treatment, however, showed little effect on the growth of Gram‐negative bacteria (including Escherichia coli O157:H7 and Pseudomonas aeruginosa ) . This selective bactericidal activity is partially attributed to the comparatively positive surface charge, which enables more effective electrostatic interactions with the negatively charged NCs, of Gram‐positive bacteria.…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

“…B) Atomic force microscopic images of A) S. aureus , B) B. subtilis , C) E. coli , and D) P. aeruginosa , i) after treatment with phosphate buffer or ii) after 10‐min incubation with tannic acid‐stabilized Cu NCs. Reproduced with permission . 2019, Elsevier.…”

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

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Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

2020

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Theranostics refers to the incorporation of therapeutic and diagnostic functions into one material system. An important class of nanomaterials exploited for theranostics is metal nanoclusters (NCs). In contrast to gold and silver NCs, copper is an essential trace element for humans. It can be more easily removed from the body. This, along with the low cost of copper that offers potential large‐scale nanotechnology applications, means that copper NCs have attracted great interest in recent years. The latest advances in the design, synthesis, surface engineering, and applications of copper NCs in disease diagnosis, monitoring, and treatment are reviewed. Strategies to control and enhance the emission of copper NCs are considered. With this synopsis of the up‐to‐date development of copper NCs as theranostic agents, it is hoped that insights and directions for translating current advances from the laboratory to the clinic can be further advanced and accelerated.

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Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 81%

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 93%

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

Section: Working Principles Of Cu Ncs As Theranostic Agentsmentioning

confidence: 99%

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Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

2020

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Facile Synthesis of Zn²⁺‐Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections

Huang

Gao

et al. 2021

Adv Funct Materials

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Transition metal ions such as Ag + , Cu 2+ , and Zn 2+ are utilized as sterile agents thousands of years ago. Unfortunately, these metal ions in the form of traditional metal or metal oxide nanoparticles cannot be directly medicated into human body due to the potential toxicity. Herein, novel Zn 2+ -ε-poly(l-lysine) (EPL)-protocatechuic aldehyde (PCA)-based hybrid nanoparticles (ZEP NPs) with on-demand release capability are synthesized for the first time by onestep coordination self-assembly of Zn 2+ , EPL, and PCA to address this issue. The ZEP NPs can effectively adhere on bacterial cells and release Zn 2+ in situ due to the decomposition of ZEP NPs in acidic infection microenvironment. More importantly, ZEP NPs exhibit excellent bactericidal ability in a proteinrich environment, in which free Zn 2+ completely loses its bactericidal ability. The excellent bactericidal effect of ZEP NPs is confirmed in a skin infection model and a lung infection model, demonstrating the great potential to deal with internal infections. Meanwhile, ZEP NPs exhibit negligible toxicity since the dose of Zn 2+ can be significantly reduced compared to the commercial zinc oxide nanoparticles (ZnO NPs). The outstanding bactericidal ability as well as negligible toxicity of ZEP NPs makes it ideal candidate of next generation antibacterial agents in treating internal infections.

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Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine

Song

Lan

et al. 2021

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Spherical nucleic acids (SNAs) are composed of a nanoparticle core and a layer of densely arranged oligonucleotide shells. After the first report of SNA by Mirkin and coworkers in 1996, it has created a significant interest by offering new possibilities in the field of gene and drug delivery. The controlled aggregation of oligonucleotides on the surface of organic/inorganic nanoparticles improves the delivery of genes and nucleic acid–based drugs and alters and regulates the biological profiles of the nanoparticle core within living organisms. Here in this review, we present an overview of the recent progress of SNAs that has speeded up their biomedical application and their potential transition to clinical use. We start with introducing the concept and characteristics of SNAs as drug/gene delivery systems and highlight recent efforts of bioengineering SNA by imaging and treatmenting various diseases. Finally, we discuss potential challenges and opportunities of SNAs, their ongoing clinical trials, and future translation, and how they may affect the current landscape of clinical practices. We hope that this review will update our current understanding of SNA, organized oligonucleotide aggregates, for disease diagnosis and treatment.

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Improvement of antibacterial activity of copper nanoclusters for selective inhibition on the growth of gram-positive bacteria

Cited by 49 publications

References 35 publications

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Facile Synthesis of Zn²⁺‐Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections

Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine

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Improvement of antibacterial activity of copper nanoclusters for selective inhibition on the growth of gram-positive bacteria

Cited by 49 publications

References 35 publications

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Development of Copper Nanoclusters for In Vitro and In Vivo Theranostic Applications

Facile Synthesis of Zn2+‐Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections

Spherical nucleic acids: Organized nucleotide aggregates as versatile nanomedicine

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Facile Synthesis of Zn²⁺‐Based Hybrid Nanoparticles as a New Paradigm for the Treatment of Internal Bacterial Infections