Improvement of antioxidant activity of oregano (Origanum vulgare L.) with an oral pharmaceutical form

Torre, María Pilar de; Vizmanos, José Luis; Cavero, Rita Yolanda; Calvo, María Isabel

doi:10.1016/j.biopha.2020.110424

Cited by 26 publications

(19 citation statements)

References 27 publications

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“…In 2018, Dzotam et al [ 80 ], using extracts of nutmeg rich in 7-trihydroxyflavone, observed an antibacterial activity of such extracts against the multidrug resistant Gram-negative bacteria Providencia stuartii and Escherichia coli . A recent study showed that Thymus extract rich in rosmarinic acid and 3,4-dihydroxybenzoic acid was capable of exhibiting antiradical and antioxidant properties and enhanced gastrointestinal digestion [ 81 ].…”

Section: Plant Bioactive Phenolic Compoundsmentioning

confidence: 99%

Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants

Pinto

Aires

Cosme

et al. 2021

Foods

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Polyphenols, as well as volatile compounds responsible for aromatic features, play a critical role in the quality of vegetables and medicinal, and aromatic plants (MAPs). The research conducted in recent years has shown that these plants contain biologically active compounds, mainly polyphenols, that relate to the prevention of inflammatory processes, neurodegenerative diseases, cancers, and cardiovascular disorders as well as to antimicrobial, antioxidant, and antiparasitic properties. Throughout the years, many researchers have deeply studied polyphenols and volatile compounds in medicinal and aromatic plants, particularly those associated with consumer’s choices or with their beneficial properties. In this context, the purpose of this review is to provide an overview of the presence of volatile and nonvolatile compounds in some of the most economically relevant and consumed vegetables and medicinal and aromatic plants, with an emphasis on bioactive polyphenols, polyphenols as prebiotics, and, also, the most important factors that affect the contents and profiles of the volatile and nonvolatile compounds responsible for the aromatic features of vegetables and MAPs. Additionally, the new challenges for science in terms of improving polyphenol composition and intensifying volatile compounds responsible for the positive characteristics of vegetables and medicinal and aromatic plants are reported.

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Section: Plant Bioactive Phenolic Compoundsmentioning

confidence: 99%

Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants

Pinto

Aires

Cosme

et al. 2021

Foods

View full text Add to dashboard Cite

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“…These formulations are also intended to protect the sensitive oregano extract compounds against oxidation. Additionally, the encapsulation of the extracts in water-soluble microcapsules can protect physically the active components during storage and, moreover, during the digestion process, favoring the maintenance of their antioxidant activity [ 92 ]. Oregano extracts were effectively microencapsulated in maltodextrin and the concentration of phenolics and flavonoids was higher when 10% instead of 15% maltodextrin was used.…”

Section: Oreganomentioning

confidence: 99%

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

et al. 2021

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Rosemary, oregano, pink savory, lemon balm, St. John’s wort, and saffron are common herbs wildly grown and easily cultivated in many countries. All of them are rich in antioxidant compounds that exhibit several biological and health activities. They are commercialized as spices, traditional medicines, or raw materials for the production of essential oils. The whole herbs or the residues of their current use are potential sources for the recovery of natural antioxidant extracts. Finding effective and feasible extraction and purification methods is a major challenge for the industrial production of natural antioxidant extracts. In this respect, the present paper is an extensive literature review of the solvents and extraction methods that have been tested on these herbs. Green solvents and novel extraction methods that can be easily scaled up for industrial application are critically discussed.

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“…Pure RA was found to be relatively stable in various pH mediums, while the extracts containing RA showed a reduction of RA content [31,32], up to 99 % in the case of thyme [31]. An in vitro study comparing 2 formulations, divided powder and hard gelatine capsules, demonstrated that capsules should be the preferred form of intake for oregano (Origanum vul- , as they protect the present RA from the process of gastrointestinal digestion [33]. The gut microbiota represents an important organ with a significant role in the metabolism of nutrients, drugs, and other xenobiotics [34].…”

Section: Impact Of the Gastrointestinal Tractmentioning

confidence: 99%

Rosmarinic Acid–Human Pharmacokinetics and Health Benefits

et al. 2020

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Rosmarinic acid is a phenolic compound commonly found in the Lamiaceae (Labiateae) plant species. It is considered responsible for a wide spectrum of biological and pharmacological activities of plants containing this compound. The aim of the current review is to present the fate of rosmarinic acid inside the human body, explained through pharmacokinetic steps and to briefly present the health benefits of RA. Pharmacokinetics was at first studied in animal models, but several studies were conducted in humans as well. This compound can be applied topically, pulmonary, intranasally, and via intravenous infusion. However, peroral application is the main route of entry into the human body. Presumably, it is mainly metabolized by the gut microflora, providing simple, more easily absorbed phenolic units. Inside the body, the rosmarinic acid molecule undergoes structural changes, as well as conjugation reactions. Renal excretion represents the main path of elimination. Previously conducted studies reported no serious adverse effects of herbal remedies containing RA, as well as their positive effects on human health. In addition to in vitro studies, clinical investigations suggested its benefits in dermatological, allergic, and osteoarthritic disorders, as well as for improving cognitive performance and in metabolic syndrome treatment. Future studies should investigate the kinetics during long-term application in patients who would have potential benefits from RA usage. Pharmaceutical formulations designed to prevent the fast metabolism of RA and allow its penetration into other compartments of the human body are also interesting topics for future research.

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Improvement of antioxidant activity of oregano (Origanum vulgare L.) with an oral pharmaceutical form

Cited by 26 publications

References 27 publications

Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants

Bioactive (Poly)phenols, Volatile Compounds from Vegetables, Medicinal and Aromatic Plants

Six Common Herbs with Distinctive Bioactive, Antioxidant Components. A Review of Their Separation Techniques

Rosmarinic Acid–Human Pharmacokinetics and Health Benefits

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