Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes

Dargah, Motahareh Shabani; Hadjizadeh, Afra

doi:10.1080/02652048.2022.2135783

Cited by 6 publications

(3 citation statements)

References 41 publications

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“…The retention of the drug in the skin was significantly higher in the case of coated formulations (F2 and F4) compared to their noncoated counterparts ( p ≤ 0.05; Figure ). This could be due to the higher viscosity, mucoadhesive, and bioadhesive nature of hyaluronic acid . The formulation prepared with double surfactants thus achieved improved drug permeation; however, coating with hyaluronic improved the retention of the drug in the skin.…”

Section: Resultsmentioning

confidence: 99%

5-Fluorouracil-Loaded Hyaluronic Acid-Coated Niosomal Vesicles: Fabrication and Ex Vivo Evaluation for Skin Drug Delivery

Khalid,

Shah,

Saeed

et al. 2023

ACS Omega

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Section: Resultsmentioning

confidence: 99%

5-Fluorouracil-Loaded Hyaluronic Acid-Coated Niosomal Vesicles: Fabrication and Ex Vivo Evaluation for Skin Drug Delivery

Khalid,

Shah,

Saeed

et al. 2023

ACS Omega

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“…The use of CAFF in cosmetic products with concentrations up to 3% is considered safe, and not toxic to human skin [32]. While some researchers loaded AA and CAFF onto niosomes [33,34], others prepared them as a MN array [35,36]. However, none of these studies involved loading AA and CAFF as niosomes onto the MN array.…”

Section: Introductionmentioning

confidence: 99%

Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

et al. 2023

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Ascorbic acid (AA) and caffeine (CAFF) work to protect cells from ultraviolet (UV) radiation and slow down the photoaging process of the skin. However, cosmetic application of AA and CAFF is limited due to poor penetration across the skin and rapid oxidation of AA. The aim of this study was to design and evaluate the dermal delivery of dual antioxidants utilizing microneedles (MNs) loaded with AA and CAFF niosomes. The niosomal nanovesicles were prepared using the thin film method and had particle sizes ranging from 130.6–411.2 nm and a negative Zeta potential of around −35 mV. The niosomal formulation was then combined with polyvinylpyrrolidone (PVP) and polyethylene glycol 400 (PEG 400) to create an aqueous polymer solution. The best skin deposition of AA and CAFF was achieved with the formulation containing 5% PEG 400 (M3) and PVP. Furthermore, the role of AA and CAFF as antioxidants in preventing cancer formation has been well-established. Here we validated the antioxidant properties of ascorbic acid (AA) and caffeine (CAFF) in a novel niosomal formulation referred to as M3 by testing its ability to prevent H2O2-indued cell damage and apoptosis in MCF-7 breast cancer cells. Results showed that M3 was able to shield MCF-7 cells from H2O2 induced damage at concentrations below 2.1 µg/mL for AA and 1.05 µg/mL for CAFF, and also exhibited anticancer effects at higher concentrations of 210 µg/mL for AA and 105 µg/mL. The formulations were stable for two months at room temperature in terms of moisture and drug content. The use of MNs and niosomal carriers could be a promising approach for dermal delivery of hydrophilic drugs like AA and CAFF.

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“…Then, DHA further irreversibly hydrolyzes to form 2,3-diketogulonic acid. During the last decades, a number of research groups have proposed different strategies to decelerate AA oxidation and to study its antioxidant activity, including encapsulation of the molecule in W/O, O/W, and W/O/W emulsions [ 7 , 8 ] and nanoemulsions [ 9 ], liposomes [ 10 ], niosomes [ 11 , 12 ], acid serums [ 13 ], and inorganic nanocapsules [ 14 ]. Other approaches are related to synthetizing AA derivatives [ 15 ] and formulating with redox partners such as Vitamin E [ 16 ].…”

Section: Introductionmentioning

confidence: 99%

Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization

Loza-Rodríguez,

Millán-Sánchez,

López

2023

Gels

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Ascorbic acid (AA) has many health benefits, including immune and cardiovascular deficiency protection, prenatal problems, and skin diseases. Unfortunately, AA is easily oxidized and has limited bioavailability. Thus, the development of formulations that stabilize and enhance the efficacy of AA is a challenge. In this study, 4% AA was encapsulated in two recently developed gels, a hydrogel and a bigel. The hydrogel was formed exclusively with lipids and water, and the bigel was a combination of the hydrogel with an oleogel formed with olive oil and beeswax. The effect of AA in gel microstructures was determined using X-ray scattering, rheology, and texture analysis. Additionally, the capacity of these materials to protect AA from degradation upon temperature and sunlight was studied. Results showed that the incorporation of AA into both materials did not affect their microstructure. Moreover, hydrogel-protected AA showed only 2% degradation after three months at 8 °C, while in aqueous solution, it degraded by 12%. Regarding sunlight, bigel showed a good shielding effect, exhibiting only 2% AA degradation after 22 h of exposure, whereas in aqueous solution, AA degraded by 10%. These results suggest that both proposed gels could be used in biomedical applications and the field of food.

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Improvement of ascorbic acid delivery into human skin via hyaluronic acid-coated niosomes

Cited by 6 publications

References 41 publications

5-Fluorouracil-Loaded Hyaluronic Acid-Coated Niosomal Vesicles: Fabrication and Ex Vivo Evaluation for Skin Drug Delivery

5-Fluorouracil-Loaded Hyaluronic Acid-Coated Niosomal Vesicles: Fabrication and Ex Vivo Evaluation for Skin Drug Delivery

Development and Evaluation of an Innovative Approach Using Niosomes Based Polymeric Microneedles to Deliver Dual Antioxidant Drugs

Characteristics of a Lipid Hydrogel and Bigel as Matrices for Ascorbic Acid Stabilization

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