Improvement of barrier function and stimulation of colonic epithelial anion secretion by<i>Menoease Pills</i>

Zhu, Jinxia; Yang, Ning; Zhang, Guihong; Tsang, Lai-Ling; Gou, Yu-Lin; Wong, Hoi Man; Chung, Yiu-Wa; Chan, Hsiao-Chang

doi:10.3748/wjg.v10.i17.2514

Cited by 2 publications

(3 citation statements)

References 21 publications

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“…These data may provide a mechanistic basis for the efficacy of this drug while also underscoring the physiological importance of alternative epithelial chloride channels in the transport function of the intestine. Similarly, ligustrazine, the active constituent of a traditional Chinese medicine for postmenopausal women, was shown to activate CFTR-dependent chloride secretion in intestinal epithelial cells while improving barrier function secondary to upregulation of the tight junctional proteins ZO-1 and ZO-2 [131], implying it might be useful to alleviate symptoms of constipation in the elderly. Finally, yet another laxative, phenophthalein, evokes epithelial potassium secretion, which would also be expected to drive fluid transport into the intestinal lumen [132].…”

Section: Novel Modulators Of Transport Function With Therapeutic Implmentioning

confidence: 98%

Intestinal epithelial secretion and barrier function: from bench to bedside

Barrett

2005

Eur Surg

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Zusammenfassung. Grundlagen: Flüssigkeitssekre-tion und Barrierefunktion sind wichtige Eigenschaften des intestinalen Epithels. Die experimentellen Modelle, welche maßgeblich unser Verständnis für epitheliale Funktionen und ihre molekularen Mechanismen ermöglicht haben, sind vielen unbekannt.Methodik: Literaturübersicht experimenteller Studien über Grundlagen zur intestinalen Flüssigkeitssekretion und epithelialen Barrierefunktion.Ergebnisse: Ergebnisse von In-vitro-und In-vivo-Studien und deren Bedeutung für das Verständnis der intestinalen Elektrolyttransportmechanismen und der epithelialen Integrität werden diskutiert.Schlussfolgerungen: Experimentelle gastrointestinale Grundlagenforschung liefert Informationen von praktischklinischer Relevanz. Der gegenseitige "bench to bedside"-Dialog zwischen experimenteller und praktischer Medizin trägt wesentlich dazu bei, die den Erkrankungen zugrunde liegenden Prozesse besser zu verstehen und damit unsere Therapiekonzepte gastrointestinaler Erkrankungen zu verbessern.Schlüsselwörter: experimentelle Medizin, UssingKammer, T84-Zellen, Epithelintegrität, intestinale Sekretion.Summary. Background: Fluid secretion and the ability to form a barrier are critical functions of the intestinal epithelium. However, some clinicians may not have an understanding of the model systems that have been used to enhance our knowledge of these important epithelial functions and their molecular regulation.Methods: This article seeks to explain the basis of intestinal fluid secretion and barrier function, and modification of these processes in pathophysiological settings, by reviewing recent basic science literature.Results: Findings from studies conducted both in vivo and in vitro are discussed, with an emphasis on insights that have emerged by applying intestinal epithelial cell lines to investigations of electrolyte transport and the integrity of the epithelial barrier.Conclusions: Even basic observations in reductionist model systems can yield information that is of immediate and practical clinical relevance. Continued bidirectional "bench to bedside" dialogue may enhance the clinician's ability to intervene in gastrointestinal diseases.

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Section: Novel Modulators Of Transport Function With Therapeutic Implmentioning

confidence: 98%

Intestinal epithelial secretion and barrier function: from bench to bedside

Barrett

2005

Eur Surg

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“…Even neurological function could be subject to impairment by compromise of the paracellular barrier separating blood from cerebrospinal fluid, as the electrolyte composition of that fluid compartment is changed . Renal insufficiency, arthritis, chronic diarrhea or constipation, ocular disorders relating to the cornea or retina, auditory disorders relating to the cochlea, prostatic hyperplasia, pulmonary disease, and specific neurological disorders—all age‐related pathologies—can likely be traced, at least in part, to transepithelial and transendothelial leaks …”

Section: The Singular Importance Of Epithelial Barriers In Higher Animentioning

confidence: 99%

“…8 Renal insufficiency, arthritis, chronic diarrhea or constipation, ocular disorders relating to the cornea or retina, auditory disorders relating to the cochlea, prostatic hyperplasia, pulmonary disease, and specific neurological disorders-all age-related pathologies-can likely be traced, at least in part, to transepithelial and transendothelial leaks. [9][10][11][12][13][14][15][16]…”

Section: The Singular Importance Of Epithelial Barriers In Higher Animentioning

confidence: 99%

Methionine restriction fundamentally supports health by tightening epithelial barriers

Mullin

Skrovanek

Ramalingam

et al. 2015

Annals of the New York Academy of Sciences

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Dietary methionine restriction (MR) has been found to affect one of the most primary tissue-level functions of an organism: the efficiency with which the epithelial linings of major organs separate the fluid compartments that they border. This process, epithelial barrier function, is basic for proper function of all organs, including the lung, liver, gastrointestinal tract, reproductive tract, blood-brain barrier, and kidney. Specifically, MR has been found to modify the protein composition of tight junctional complexes surrounding individual epithelial cells in a manner that renders the complexes less leaky. This has been observed in both a renal epithelial cell culture model and in gastrointestinal tissue. In both cases, MR increased the transepithelial electrical resistance across the epithelium, while decreasing passive leak of small nonelectrolytes. However, the specific target protein modifications involved were unique to each case. Overall, this provides an example of the primary level on which MR functions to modify, and improve, an organism.

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Improvement of barrier function and stimulation of colonic epithelial anion secretion byMenoease Pills

Cited by 2 publications

References 21 publications

Intestinal epithelial secretion and barrier function: from bench to bedside

Intestinal epithelial secretion and barrier function: from bench to bedside

Methionine restriction fundamentally supports health by tightening epithelial barriers

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