Improvement of Blood Pressure Control in Renal Transplant Recipients—Retrospective Longitudinal Study

Adrych, Dorota; Kuźmiuk-Glembin, Izabella; Tylicki, Leszek; Heleniak, Zbigniew; Garnier, Hanna; Wiśniewski, Jakub Bożydar; Rutkowski, Przemysław; Rutkowski, Bolesław; Dębska-Ślizień, Alicja

doi:10.1016/j.transproceed.2017.11.023

Cited by 3 publications

(2 citation statements)

References 16 publications

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“…However, this study assessed BP only at a single outpatient visit and did not assess the relationship between BP control and clinical outcomes. BP control (<140/<90 mm Hg) has also been reported to be poor among kidney transplant recipients, ranging from 40%‐56%, and poor control has been linked to graft failure, increased CVEs, and mortality . To our knowledge, BP control has not previously been linked to clinical outcomes among LTRs.…”

Section: Introductionmentioning

confidence: 91%

“…BP control (<140/<90 mm Hg) has also been reported to be poor among kidney transplant recipients, ranging from 40%-56%, and poor control has been linked to graft failure, increased CVEs, and mortality. [10][11][12][13] To our knowledge, BP control has not previously been linked to clinical outcomes among LTRs. We therefore sought to assess clinician adherence to clinical practice guidelines for BP management of LTRs at a large urban tertiary care network and to assess whether BP control predicts mortality and clinical CVEs in this high-risk population.…”

Section: Introductionmentioning

confidence: 92%

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Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients

VanWagner

Holl

Montag

et al. 2020

American Journal of Transplantation

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Data for liver transplant recipients (LTRs) regarding the benefit of care concordant with clinical practice guidelines for management of blood pressure (BP) are sparse. This paper reports on clinician adherence with BP clinical practice guideline recommendations and whether BP control is associated with mortality and cardiovascular events (CVEs) among LTRs. We conducted a longitudinal cohort study of adult LTRs who survived to hospital discharge at a large tertiary care network between 2010 and 2016. The primary exposure was a BP of <140/<90 mm Hg within year 1 of LT. Among 602 LTRs (mean age 56.7 years, 64% men), 92% had hypertension and 38% had new onset hypertension. Less than 30% of LTRs achieved a BP of <140/<90 mm Hg over a mean of 43.2 months. In multivariable models, adjusted for key confounders, BP control post‐LT compared with lack of control was associated with a significantly lower hazard of mortality (hazard ratio [HR] 0.48, 95% confidence interval [CI] 0.39, 0.87) and of CVEs (HR 0.65, 95% CI 0.43, 0.97). The association between BP control of <140/<90 mm Hg with improved survival and decreased CVEs in LTRs suggests that efforts to improve clinician adherence to BP clinical practice recommendations should be intensified.

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Section: Introductionmentioning

confidence: 91%

Section: Introductionmentioning

confidence: 92%

Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients

VanWagner

Holl

Montag

et al. 2020

American Journal of Transplantation

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Frequency and Patterns of Prescribing Antihypertensive Agents in Outpatient Kidney Transplant Recipients Among Six Cities in China from 2011 to 2018

Hou

Shen

et al. 2021

Clinical Therapeutics

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Antihypertensive Drug Usage and Target Blood Pressure Attainment in Postrenal Transplant: A Prospective Study in Indian Population

Chatterjee

Choudhury

Chaudhury

2023

Indian Journal of Transplantation

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Introduction: The etiology of hypertension in post renal transplant patients is multifold and effective control of blood pressure (BP) contributes towards proper graft functioning and reduces risk of cardiovascular diseases. This prospective observational study was undertaken to evaluate the prevalence of antihypertensive drug use, the prescribing pattern and trends of blood pressure control in a cohort of post renal transplant patients from eastern India. Materials and Methods: Patients who had undergone renal transplant in this public hospital were enrolled as per eligibility criteria. All enrolled patients were on antihypertensive from at least 3months prior to transplant and were followed upto one year post-transplant. Antihypertensive drug (AHD) and immunosuppressant intake, BP recordings and occurrence of major adverse cardiac events (MACE), if any were noted at each visit. Results: 56 patients were enrolled with a mean age of 33.04 ± 9.96 years, 87.5% were male. 75% were hypertensive at discharge (2-3 weeks post-transplant). Percentage of patients on AHD at 3, 6, 9 and 12 months post-transplant were 83.9%, 82.1%, 75% and 71.4% respectively. Amlodipine was the most common prescribed AHD. Target BP control (≤130/80 mm of Hg) was achieved in 62.5% patients at 1year post-transplant. There were no major adverse cardiac events (MACE) during the study period. Conclusion: In our study comprising of a relatively young cohort of transplant patients from India, hypertension control was well achieved in majority of the subjects and no MACE were noted. Amlodipine was the most commonly used AHD either as monotherapy or in combination with beta-blocker. Long term follow up of this cohort shall provide further insights into the trends of such control.

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Improvement of Blood Pressure Control in Renal Transplant Recipients—Retrospective Longitudinal Study

Cited by 3 publications

References 16 publications

Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients

Blood pressure control according to clinical practice guidelines is associated with decreased mortality and cardiovascular events among liver transplant recipients

Frequency and Patterns of Prescribing Antihypertensive Agents in Outpatient Kidney Transplant Recipients Among Six Cities in China from 2011 to 2018

Antihypertensive Drug Usage and Target Blood Pressure Attainment in Postrenal Transplant: A Prospective Study in Indian Population

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