Improvement of C-Reactive Protein Levels and Body Temperature of an Elderly Patient Infected with<i>Pseudomonas aeruginosa</i>on Treatment with Mao-Bushi-Saishin-To

Kamei, Tsutomu; Kondoh, Tatsuro; Nagura, Satoshi; Toriumi, Yoshitaka; Kumano, Hiroaki; Tomioka, Haruaki

doi:10.1089/acm.2000.6.235

Cited by 16 publications

(5 citation statements)

References 8 publications

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“…In addition, Ephedrae is less reported on antidepressants. From the clinical application of MFX, MFX is widely used in respiratory and immune system diseases due to strong anti-inflammation and antianaphylaxis [35, 39, 65, 66]. Nevertheless, the impact on antidepressant is limited.…”

Section: Discussionmentioning

confidence: 99%

Mahuang-Fuzi-XixinDecoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

et al. 2019

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Evidence suggests that inflammation and neurogenesis play an important role in major depressive disorder (MDD). Mahuang-Fuzi-Xixin decoction (MFX), as the traditional Chinese prescription, has been widely applied for asthma, migraine, and MDD in clinics. However, the effects of MFX on the potential mechanism in MDD are still unclear. Hence, the present study is aimed at exploring whether the antidepressive effect of MFX is connected to the anti-inflammatory and promoting neurogenesis. Besides, lipopolysaccharide (LPS) of Gram-negative bacteria can induce depressive-like behaviors. We demonstrated that administration of MFX corrected the depressive-like behaviors in LPS-induced mice and significantly decreased the expression of IL-1β in the hippocampus. LPS injection induced a significant increase in the levels of NLRP3, cleaved caspase-1 p20, and ASC in the hippocampus, as well as Trx-interacting protein (TXNIP), and MFX could reverse this change. What is more, treatment of MFX increased the level of doublecortin (DCX), brain-derived neurotrophic factor (BDNF), and tropomyosin-related kinase receptor B (TrkB) in the hippocampus which means that MFX could promote the neurogenesis. In conclusion, the study indicates that MFX relieves a depressive-like state in LPS-induced mice through the inhibition of the NLRP3 inflammasome and the enhancement of the neurogenesis pathway.

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Section: Discussionmentioning

confidence: 99%

Mahuang-Fuzi-XixinDecoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

et al. 2019

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“…A. radix is primarily derived from either Asiasarum heterotropoides or Asiasarum sieboldii (6). Studies has been performed regarding the anti-inflammatory and anti-allergy effects of A. radix (7,8).…”

Section: Introductionmentioning

confidence: 99%

Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva

Jeong

Lee

Jin

et al. 2014

Molecular Medicine Reports

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“…For example, previous studies using mice showed that the administration of MBST increases the production of the titer of antibodies against influenza, especially in older mice [ 15 , 16 ]. On the other hand, Kamei et al (2000) reported a case study showing that MBST remitted inflammatory markers and fever; in brief, fever and C-reactive protein levels returned to normal in an elderly patient even though antibiotics did not improve the outcome [ 17 ]. Results of these clinical studies and some preclinical evidence [ 18 , 19 , 20 , 21 ] indicate that MBST may be effective against upper respiratory tract infection because of its anti-inflammatory effect and adjuvanticity.…”

Section: Introductionmentioning

confidence: 99%

In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix

et al. 2020

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The Japanese traditional medicine maobushisaishinto (MBST) has been prescribed for treating upper respiratory tract infections, such as a common cold. However, its mode of action is poorly understood, especially concerning the MBST constituent Asiasari Radix (AR). In this study, we focused on AR, with an objective of clarifying its bioavailable active ingredients and role within MBST by performing pharmacokinetic and pharmacological studies. Firstly, we performed qualitative non-targeted analysis utilizing high-resolution mass spectrometry to explore the bioavailable ingredients of AR as well as quantitative targeted analysis to reveal plasma concentrations following oral administration of MBST in rats. Secondly, we performed in vitro pharmacological study of bioavailable AR ingredients in addition to other ingredients of MBST to confirm any agonistic activities against transient receptor potential (TRP) channels. As a result, methyl kakuol and other compounds derived from AR were detected in the rat plasma and showed agonistic activity against TRPA1. This study suggests that methyl kakuol as well as other compounds have the potential to be an active ingredient in AR and thus presumably would contribute in part to the effects exerted by MBST.

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Improvement of C-Reactive Protein Levels and Body Temperature of an Elderly Patient Infected withPseudomonas aeruginosaon Treatment with Mao-Bushi-Saishin-To

Abstract: In cases in which the fever does not fall in response to antibiotics for at least 3 days, half of the standard dose of Mao-bushi-saishin-to for 7 days might be worth trying to induce remission, especially for elder patients.

Cited by 16 publications

References 8 publications

Mahuang-Fuzi-XixinDecoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

Mahuang-Fuzi-XixinDecoction Reverses Depression-Like Behavior in LPS-Induced Mice by Regulating NLRP3 Inflammasome and Neurogenesis

Effects of Asiasari radix on the morphology and viability of mesenchymal stem cells derived from the gingiva

In Vivo Pharmacokinetic Analysis Utilizing Non-Targeted and Targeted Mass Spectrometry and In Vitro Assay against Transient Receptor Potential Channels of Maobushisaishinto and Its Constituent Asiasari Radix

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