Improvement of chemical analysis of antibiotics

Critical ReviewMethods for the detection of polyether ionophore residues in poultry

“…48 Subsequent studies showed that this technique could also be used for lasalocid and narasin. 49 Although this group went on to develop a method for the determination of lasalocid, monensin and salinomycin in animal feeds, 50 another Japanese group described the use of the same derivative for the analysis of residues of monensin and salinomycin. 44 Their method produced well-resolved peaks, with no interfering peaks at the retention time of either compound.…”

Periodicity in collision-induced and remote-bond activation of alkali metal ions attached to polyether ionophores

“…3 Because of this, many studies have been undertaken to extract, identify, and monitor concentrations of the polyether ionophores both in vivo and in vitro. 4 Prior to 1997, the primary technique for detection and characterization of ionophores was based around post column derivatization to give UV-absorbing chromophore complexes for high-performance liquid chromatography (HPLC), [5][6][7] or by the use of thin layer chromatography (TLC). 8 With the advent of tandem mass spectrometry, and LC-MS/MS, fragmentation patterns can now be used in conjunction with chromatography to give a more complete picture of the molecular composition of a chromatographic peak.…”