Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats

Luo, Qihui; Cheng, Dongjing; Huang, Chao; Li, Yifan; Lao, Chengjie; Xia, Yu; Li, Wentao; Gong, Xiao; Hu, Danlei; Li, Bin; He, Xue; Chen, Zhengli

doi:10.3390/molecules24061139

Cited by 67 publications

(63 citation statements)

References 66 publications

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“…Likewise, olive oil supplements improved the severity of dextran sulfate sodium-induced colitis in mice [ 66 ]. Furthermore, evidence showed that complement of soy isoflavones improved intestinal permeability, lowered serum lipid, inhibited inflammatory response, and corrected intestinal microbiota imbalance of obese rats [ 67 ].…”

Section: Dyslipidemia Accelerates Colitis-associated Crcmentioning

confidence: 99%

The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer

Chen

Guo

Zhang

et al. 2021

Journal of Oncology

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Dyslipidemia, characterized by metabolic abnormalities, has become an important participant in colorectal cancer (CRC). Dyslipidemia aggravates intestinal inflammation, destroys the protective mucous layer, and disrupts the balance between injury and recovery. On the other hand, antioxidants induced by oxidative stress enhance glycolysis to maintain the acquisition of ATP allowing epithelial cells with damaged genomes to survive. In the repetitive phase of colitis, survival factors enable these epithelial cells to continuously proliferate. The main purpose is to restore and rebuild damaged mucosa, mainly aiming to recover mucosal damage and reconstruct mucosa, but it is also implicated in the occurrence and malignancy of CRC. The metabolic reprogramming of aerobic glycolysis and lipid synthesis enables these transformed epithelial cells to convert raw carbohydrate and amino acid substrates, thereby synthesizing protein and phospholipid biomass. Stearoyl-CoA desaturase, responsible for the fatty acid desaturation, improves the fluidity and permeability of cell membranes, which is one of the key factors affecting metabolic rate. In response to available fat, tumor cells reprogram their metabolism to better plunder energy-rich lipids and rapidly scavenge these lipids through continuous proliferation. However, lipid metabolic disorders inhibit the function of immune-infiltrating cells in the tumor microenvironment through the cross-talk between tumor cells and immunosuppressive stromal cells, thereby providing opportunities for tumor progress. Nonsteroidal anti-inflammatory drugs and lipid-lowering drugs can decrease the formation of aberrant crypt foci, lower the burden of the adenomatous polyp, and reduce the incidence of CRC. This review provides a comprehensive understanding of dyslipidemia on tumorigenesis and tumor progression and a development prospect of lipid disorders on tumor immunity.

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Section: Dyslipidemia Accelerates Colitis-associated Crcmentioning

confidence: 99%

The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer

Chen

Guo

Zhang

et al. 2021

Journal of Oncology

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“…For example, the study of Luo et al show that soy isoflavones decrease food intake and body weight gain in mice [18]. Moreover, soy isoflavones can regulate lipid metabolism through AKT/mTORC1 pathway [19] and improve the colonic immune function in obese rats induced by high-fat diet [20]. However, the effects of soy isoflavones on hypothalamus under obesity condition are not well defined, especially describing this from oxidative stress aspect.…”

Section: Introductionmentioning

confidence: 99%

Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway

Pang

Yang

Luo

et al. 2020

Aging

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Obesity is a common metabolic disorder that increases the risk of many diseases, such as type II diabetes, hypertension, cardiovascular disease. Hypothalamus plays a very important role in the progression of obesity, and many studies reveal that hypothalamic injures are implicated in obesity processes. Here, we describe that the consumption of soy isoflavones, with a structural similarity to that of estradiol, could mitigate obesity through improving the hypothalamic inflammation and apoptosis, which are induced by oxidative stress. Also, our in vitro studies demonstrate that daidzein and genistein, common ingredients of soy isoflavones, could protect hypothalamic N42 cells against palmitic acid induced oxidative stress and apoptosis. Moreover, the transcriptional coactivator peroxisome proliferator-activated receptor γ coactivator 1 alpha (PGC1-alpha), which plays a role in oxidative defense, is increased after soy isoflavone treatment in vivo and in vitro, suggesting an improved effect of soy isoflavones on hypothalamic antioxidant defense is mediated by PGC-1α. Our study reveals a potential mechanism of soy isoflavones regulating oxidative stress induced hypothalamic inflammation and cellular apoptosis, which will be important for obesity treatment.

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“…Significantly higher food consumption was recorded in three studies [2-PPC [ 41 , 50 ], 1-PE [ 73 ], while 24 studies reported non-significant difference in energy/food intake [ 45 , 46 , 47 , 51 , 52 , 57 , 59 , 60 , 62 , 63 , 66 , 74 , 75 , 80 ] ( Figure S4 ). As for bodyweight, thirty studies (67%) recorded a significant drop post-treatment, of which 16 with PPC [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 50 , 52 , 53 , 54 , 56 , 57 ], and 15 with PE [ 60 , 61 , 63 , 65 , 66 , 68 , 71 , 72 , 73 , 74 , 75 , 76 , 77 , 78 , 79 , 81 ]. Non-significant observations were made in 19 studies [11-PPC [ 37 ...…”

Section: Resultsmentioning

confidence: 99%

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

Moorthy

Sundralingam

Palanisamy

2021

Foods

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Obesity is a disease growing at an alarming rate and numerous preclinical studies have proven the role of polyphenols in managing this disease. This systematic review explores the prebiotic effect of polyphenols in the management of obesity among animals fed on a high-fat diet. A literature search was carried out in PubMed, Scopus, CINAHL, Web of Science, and Embase databases following the PRISMA guidelines. Forty-four studies reported a significant reduction in obesity-related parameters. Most notably, 83% of the studies showed a decrease in either body weight/visceral adiposity/plasma triacylglyceride. Furthermore, 42 studies reported a significant improvement in gut microbiota (GM), significantly affecting the genera Akkermansia, Bacteroides, Blautia, Roseburia, Bifidobacteria, Lactobacillus, Alistipes, and Desulfovibrio. Polyphenols’ anti-obesity, anti-hyperglycaemic, and anti-inflammatory properties were associated with their ability to modulate GM. This review supports the notion of polyphenols as effective prebiotics in ameliorating HFD-induced metabolic derangements in animal models.

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Improvement of Colonic Immune Function with Soy Isoflavones in High-Fat Diet-Induced Obese Rats

Cited by 67 publications

References 66 publications

The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer

The Role of Dyslipidemia in Colitis-Associated Colorectal Cancer

Soy isoflavones improve the oxidative stress induced hypothalamic inflammation and apoptosis in high fat diet-induced obese male mice through PGC1-alpha pathway

Polyphenols as Prebiotics in the Management of High-Fat Diet-Induced Obesity: A Systematic Review of Animal Studies

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