Improvement of common variable immunodeficiency using embryonic stem cell therapy in a patient with lyme disease: a clinical case report

Horowitz, Richard; Freeman, Phyllis R.

doi:10.1002/ccr3.1556

Cited by 4 publications

(17 citation statements)

References 62 publications

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“…Immune dysfunction/immune deficiency: This occasionally required subcutaneous or intravenous immunoglobulin therapy (IVIG), as immunoglobulins are necessary to fight infections (CVID), modulate immunity [198], heal (small fiber) neuropathy, POTS, and address autoimmune encephalopathy [199]. Improvement of CVID using embryonic stem cell therapy in Lyme disease may be an option in resistant disease [200]. More than 72% of participants had immune dysfunction.…”

Section: Discussionmentioning

confidence: 99%

Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2

Horowitz¹,

Freeman²

2018

Healthcare

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We present a precision medical perspective to assist in the definition, diagnosis, and management of Post Treatment Lyme Disease Syndrome (PTLDS)/chronic Lyme disease. PTLDS represents a small subset of patients treated for an erythema migrans (EM) rash with persistent or recurrent symptoms and functional decline. The larger population with chronic Lyme disease is less understood and well defined. Multiple Systemic Infectious Disease Syndrome (MSIDS) is a multifactorial model for treating chronic disease(s), which identifies up to 16 overlapping sources of inflammation and their downstream effects. A patient symptom survey and a retrospective chart review of 200 patients was therefore performed on those patients with chronic Lyme disease/PTLDS to identify those variables on the MSIDS model with the greatest potential effect on regaining health. Results indicate that dapsone combination therapy decreased the severity of eight major Lyme symptoms, and multiple sources of inflammation (other infections, immune dysfunction, autoimmunity, food allergies/sensitivities, leaky gut, mineral deficiencies, environmental toxins with detoxification problems, and sleep disorders) along with downstream effects of inflammation may all affect chronic symptomatology. In part two of our observational study and review paper, we postulate that the use of this model can represent an important and needed paradigm shift in the diagnosis and treatment of chronic disease.

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Section: Discussionmentioning

confidence: 99%

Precision Medicine: The Role of the MSIDS Model in Defining, Diagnosing, and Treating Chronic Lyme Disease/Post Treatment Lyme Disease Syndrome and Other Chronic Illness: Part 2

Horowitz¹,

Freeman²

2018

Healthcare

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Section: Case Studiesmentioning

confidence: 99%

“…In another case study by Horowitz et al, an 18-year-old male was observed [7]. He had an extensive history, including recurrent infections, Lyme disease, CVID, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), and celiac disease [7]. He was also suffering from neuropsychiatric disorders, including attention-deficit and hyperactivity disorder (ADHD), likely attributable to heavy metal exposure at school [7].…”

Section: Case Studiesmentioning

confidence: 99%

“…He had an extensive history, including recurrent infections, Lyme disease, CVID, pediatric autoimmune neuropsychiatric disorders associated with streptococcal infections (PANDAS), and celiac disease [7]. He was also suffering from neuropsychiatric disorders, including attention-deficit and hyperactivity disorder (ADHD), likely attributable to heavy metal exposure at school [7]. He had low IgG levels, most likely due to concomitant Lyme disease, which is known to suppress humoral immunity [7].…”

Section: Case Studiesmentioning

confidence: 99%

“…Therefore, building awareness among primary care physicians (PCPs) is very important, as treatment can help alleviate symptoms and prevent continued recurrent infections and serious complications [7]. This review article will provide insight into CVID's clinical manifestations, diagnosis, physiology/molecular basis, treatment, genetics, effects of recurrent infections, diagnostic tools, and case studies.…”

Section: Introductionmentioning

confidence: 99%

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Making a Diagnosis of Common Variable Immunodeficiency: A Review

Ghafoor

Joseph

2020

Cureus

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Common variable immunodeficiency (CVID) is a condition that inhibits the function of the immune system, making those with the condition more susceptible to infection from external pathogens, including bacteria and, less often, viruses. The immune disorder is marked by low immunoglobulin levels of immunoglobulin G (IgG) and IgA as well as IgM in some patients. These immune abnormalities typically result in recurrent sinopulmonary infections and can result in serious complications such as pneumonia and chronic lung disease. Other manifestations include poor vaccine response and defective antibodies in a patient's immune system. The disorder affects approximately one in 25,000 to one in 50,000 individuals worldwide, with the condition varying across different populations. While the underlying mechanism of disease activity remains poorly understood, only 10% of cases are known to have an underlying genetic link and approximately 25% of patients also have an autoimmune disorder. CVID commonly presents in individuals in their twenties or thirties but can present at any time between childhood through adulthood, with mortality dependent on the severity of illness and frequency of recurrent infections. Potential life-threatening consequences of CVID include malignancies, enteropathy, and autoimmune manifestations. Treatment can help alleviate symptoms and prevent continued recurrent infections and serious complications. However, the lack of awareness among primary care physicians (PCPs) makes the condition difficult to diagnose and manage. In this review article, we will provide insight into the clinical manifestations as well as the diagnosis and management of CVID. This will provide clinical practitioners with tools to recognize the disease earlier on to improve patient outcomes and prevent serious complications. We will also afford a better understanding of genetic components tied to CVID and new research efforts.

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