High thermal gradient in the interface region of melting and solidified metal during the unidirectional solidification has significant impact on the microstructures and mechanical properties of the castings. In this paper, DZ125 superalloy was solidified by directional equipment associated with liquid metal cooling medium of Ga-In alloy. Several process parameters have been chosen in order to understand the effect of thermal gradient on the castings. Comparing with traditional high rate solidification prepared DZ125 superalloy, the results show that element segregation such as Al, Ti, W and Mo was decreased with high thermal gradients or high withdraw rates, the precipitation of low melting phase in the interdendritic region was suppressed and the sizes of eutectic and c9 phase were both refined. Stress-rupture test was carried out at 980uC/235 MPa after heat treatment. Obvious stress-rupture improvement has been observed, and the stress-rupture life decrease at high withdrawal rate due to the column grain discontinuity and deflection.