Improvement of Curvulamine Production by Precursors Co-addition Strategy in Liquid Culture of Marine-Derived Fungus Curvularia sp. IFB-Z10

Marine natural products

“…285 Synthesis of (À)-curvulamine C has been achieved from commercially available starting materials 286 and its yield from the producing fungus has been improved through addition of precursors alanine and proline to the culture. 287 Known terrestrial avone chrysin 796 was isolated from Chaetomium globosum as a new MNP. 288 Completed total syntheses of fungal metabolites included those of wickerol B, 289 (+)-penostatin A and (+)-penostatin C, 290 versicotides A-C, 291 cladosin B, 292 spirograterpene A, 293 nafuredin B, 294 chondristerins I and J, 295 aspergillusene B 296 and yicathins B and C. 297 Several known compounds including nortryptoquivaline, chevalone C, tryptoquivaline H, scalin A, epi-neoscalin A and epi-scalin A potentiated the cytotoxic effect of doxorubicin in lung cancer cells 298 and the lipopeptidyl benzophenone, asperphenin A, inhibited colon cancer cell growth through G2/M cell cycle arrest followed by apoptosis.…”

“…285 Synthesis of (−)-curvulamine C has been achieved from commercially available starting materials 286 and its yield from the producing fungus has been improved through addition of precursors alanine and proline to the culture. 287 Known terrestrial flavone chrysin 796 was isolated from Chaetomium globosum as a new MNP. 288 Completed total syntheses of fungal metabolites included those of wickerol B, 289 (+)-penostatin A and (+)-penostatin C, 290 versicotides A–C, 291 cladosin B, 292 spirograterpene A, 293 nafuredin B, 294 chondristerins I and J, 295 aspergillusene B 296 and yicathins B and C. 297…”