Improvement of Depression in a Patient with Hypothyroidism and Deiodinase Polymorphism with LT3 Therapy

Ahmed, Ziyan; Sherin, Rinsha P V; Hoang, Thanh D.; Fonseca, Tatiana L.; Shakir, Mohamed K M

doi:10.22541/au.163257011.13072067/v1

2021

DOI: 10.22541/au.163257011.13072067/v1

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Improvement of Depression in a Patient with Hypothyroidism and Deiodinase Polymorphism with LT3 Therapy

Ziyan Ahmed

Rinsha P V Sherin

Thanh D. Hoang

et al.

Abstract: We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

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The Physiological Functions and Polymorphisms of Type II Deiodinase

Deng¹,

Han²,

Gao³

et al. 2023

Endocrinol Metab

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Type II deiodinase (DIO2) is thought to provide triiodothyronine (T3) to the nucleus to meet intracellular needs by deiodinating the prohormone thyroxine. DIO2 is expressed widely in many tissues and plays an important role in a variety of physiological processes, such as controlling T3 content in developing tissues (e.g., bone, muscles, and skin) and the adult brain, and regulating adaptive thermogenesis in brown adipose tissue (BAT). However, the identification and cloning of DIO2 have been challenging. In recent years, several clinical investigations have focused on the Thr92Ala polymorphism, which is closely correlated with clinical syndromes such as type 2 diabetes, obesity, hypertension, and osteoarthritis. Thr92Ala-DIO2 was also found to be related to bone and neurodegenerative diseases and tumors. However, relatively few reviews have synthesized research on individual deiodinases, especially DIO2, in the past 5 years. This review summarizes current knowledge regarding the physiological functions of DIO2 in thyroid hormone signaling and adaptive thermogenesis in BAT and the brain, as well as the associations between Thr92Ala-DIO2 and bone and neurodegenerative diseases and tumors. This discussion is expected to provide insights into the physiological functions of DIO2 and the clinical syndromes associated with Thr92Ala-DIO2.

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The Physiological Functions and Polymorphisms of Type II Deiodinase

Deng¹,

Han²,

Gao³

et al. 2023

Endocrinol Metab

View full text Add to dashboard Cite

show abstract

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Improvement of Depression in a Patient with Hypothyroidism and Deiodinase Polymorphism with LT3 Therapy

Abstract: We report a 54-year-old man with treatment-resistant depression (TRD) and hypothyroidism who responded to LT3/LT4 combination, rather than LT4 alone. He was able to discontinue all antidepressant medications eventually. Interestingly, the patient has a DIO2 polymorphism.

Cited by 1 publication

References 20 publications

The Physiological Functions and Polymorphisms of Type II Deiodinase

The Physiological Functions and Polymorphisms of Type II Deiodinase

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