Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique

Tayel, Saadia A.; Soliman, Iman; Louis, Dina

doi:10.1016/j.ejpb.2007.09.003

Cited by 96 publications

(61 citation statements)

References 10 publications

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“…L f = Ф of the carrier+ Ф of the coat (1/R) (Tayel et al, 2008). Where, R is the weight ratio of carrier (Q) to the coating material (q) present in the formulation.…”

Section: Preparation and Mixing Of The Powdersmentioning

confidence: 99%

“…The Ф-value of each mixture was calculated using the following equation: Ф-value = weight of liquid/weight of solid The Ф-values were plotted versus the corresponding angles of slide. The Ф-values corresponding to an angle of slide of 33 o was taken as the flowable liquid retention potential (Tayel et al, 2008).…”

Section: Determination Of Flowable Liquid Retention Potential For Aermentioning

confidence: 99%

“…The recorded angle of slide was taken as a measure for the flow properties of the powders. An angle of slide corresponding to 33 o was considered as the maximum angle indicating acceptable flow for liquisolid tablet manufacture (Tayel et al, 2008).…”

Section: Determination Of the Angle Of Slide Of Aerosil 200 And Avicementioning

confidence: 99%

“…Many grades of cellulose, starch, lactose, etc. can be used as carriers with silicas of very fine particle size can be used as coating materials (Tayel et al, 2008). The presence of coating materials is essential to provide flowable powder mixtures ( Nokhodchi et al, 2010).…”

Section: Introductionmentioning

confidence: 99%

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Self microemulsefying and non-self microemulsefying liquisolid tablet of felodipine

Khorshed¹,

Maghraby²

2016

J App Pharm Sci

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Liquisolid formulation involves dissolution or dispersion of the drug in a liquid before formulation of solid dosage form using solid adsorbent as a carrier. The liquid component usually utilizes simple solvent system. Self emulsifying liquids can provide another alternative liquid for enhanced dissolution. The objective of this work was to develop and evaluate non-self emulsifying and self emulsifying liquisolid tablet for enhanced dissolution rate of felodipine. The former utilized polyethylene glycol 400 which was the best solvent and the later employed a mixture of castor oil with labrasol and transcutol as self emulsifying system. A mixture of avicel PH 102 and aerosil 200 was used as solid adsorbent with croscarmellose being used as superdisintegrent. Formulation of the drug as liquisolid tablets enhanced the dissolution rate compared with the standard tablet prepared using the unprocessed drug powder with the same tablet excipients. The self emulsifying tablet showed faster release pattern compared with the non-self emulsifying tablet. The thermal analysis studies indicated the presence of the drug in a solution form in the tablet formulations. In conclusion liquisolid tablet formulation can enhance the dissolution rate of felodipine with self emulsifying liquid system being more efficient.

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“…L f = Ф of the carrier+ Ф of the coat (1/R) (Tayel et al, 2008). Where, R is the weight ratio of carrier (Q) to the coating material (q) present in the formulation.…”

Section: Preparation and Mixing Of The Powdersmentioning

confidence: 99%

Section: Determination Of Flowable Liquid Retention Potential For Aermentioning

confidence: 99%

Section: Determination Of the Angle Of Slide Of Aerosil 200 And Avicementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Self microemulsefying and non-self microemulsefying liquisolid tablet of felodipine

Khorshed¹,

Maghraby²

2016

J App Pharm Sci

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“…This angle θ represented the angle of slide. The angle of slide corresponding to 33° considered as optimal flow properties [11][12][13] .…”

Section: Angle Of Slide Measurement (θ)mentioning

confidence: 99%

Untitled

2017

IJPSR

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Olmesartan medoxomil, a BCS class II drug, is an angiotensin-II receptor antagonist used for the treatment of hypertension. A liquisolid tablet of Olmesartan medoxomil was developed to improve its dissolution and flow properties. The commonly used carrier Avicel was compared with Neusilin. Because of higher liquid load factor, Neusilin was selected as a carrier for further optimization study using 3 2 Factorial design. Two independent factors, % drug concentration in a liquid vehicle (X1) and carrier coating ratio (X2) were studied, each with three levels and the systems was assessed for two dependent variables; % drug dissolution and angle of repose. Mathematical equations and response surface plots were used to relate the dependent and independent variables. All prepared liquisolid formulations were characterized for pre-and post-compression parameters. The optimized formulation F7 (15% drug concentration and 30 carrier coating ratio) was tested for X-ray powder diffractometry and FTIR. Results showed that maximum drug dissolution was exhibited by systems with minimum drug concentration in liquid vehicle and optimum carrier to coating ratio. Optimized formulation displayed significantly enhanced dissolution profiles than that of marketed formulation. In conclusion, avicel could be replaced by neusilin for the formulation of low weight liquisolid tablets along with increased dissolution.

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Solubility of Pharmaceutical Solids

Sharma,

Gao,

et al. 2023

Oral Bioavailability and Drug Delivery

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Improvement of dissolution properties of Carbamazepine through application of the liquisolid tablet technique

Cited by 96 publications

References 10 publications

Self microemulsefying and non-self microemulsefying liquisolid tablet of felodipine

Self microemulsefying and non-self microemulsefying liquisolid tablet of felodipine

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Solubility of Pharmaceutical Solids

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