Improvement of dissolution rate of ibuprofen by solid dispersion systems with Kollicoat IR using a pulse combustion dryer system

Xu, Lu; Li, S.M.; Wang, Y.; Wei, Mingchun; Yao, Huimin; Sunada, Hisakazu

doi:10.1016/s1773-2247(09)50018-4

Cited by 10 publications

(3 citation statements)

References 23 publications

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“…[32][33][34] Moreover, it has surface-active characteristics and former studies showed that KIR is effective for SD system preparation which improves bioavailability of some BCS Class II APIs. [32][33][34][35][36] Kollidon® 90F (KF90) is a commercial grade of polyvinylpyrroydone polymer series which is usually used as a binder. 19,37 Potentiality of the aforementioned polymers were first time explored with RVT to enhance dissolution rate preparing SD formulations, since the available data is not enough to justify the polymer combinations required to enhance the dissolution rate of highly valuable drug molecule RVT.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro Dissolution Profile and Physicochemical Characterization of Polymer Based Formulations of Sparingly Soluble Rosuvastatin

Sikdar

Nazir

Alam

et al. 2021

Dhaka Univ. J. Pharm. Sci

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Rosuvastatin (RVT) is a BCS class II antilipidemic crystalline drug, which exhibits low bioavailability due to its very poor aqueous solubility; therefore, it is challenging to develop a proper formulation of RVT. To enhance solubility and bioavailability of this API, an attempt has been made by implementing solid dispersion technique. Solid dispersion (SD) technique is a solubility enhancing technique where one or more active entities are dispersed in an inert medium (matrix or carrier) at solid state. In this study, different ratios of Kollicoat® IR (KIR) and Kollidon® 90F (KF90) polymers were used with API to prepare various formulations by physical mixing (PM) and SD approaches; here solvent evaporation technique was used whereas methanol was used as solvent which was completely evaporated from the homogenously dispersed system by placing in a water-bath at 60-65°C and then in oven for 30 minutes at 50 °C. Among the formulations, RVT-KF90 SD formulations showed the most promising result in in-vitro study in terms of drug release profile (78.04 – 99.21%) in comparison to pure RVT (63.1%) and physical mixing of RVT with those polymers. USP dissolution apparatus type II was used at 37°C ± 0.5°C with 50 rpm to conduct the in-vitro experiment. The experiment also unraveled that the dissolution of RVT improved with increasing the amounts of polymers. Subsequently, stability of the developed formulations was conducted by Fourier transforms infrared spectroscopy (FTIR) and differential scanning calorimetry (DSC) as well as scanning electron microscopy (SEM). The results obtained from FTIR ensured no involvement of any significant drug-excipient interaction. Moreover, the DSC study signified thermal stability at high temperature. Besides, the SEM micrograph illustrated homogenous distribution of RVT in the polymer and transformation of crystal-like RVT into amorphous formulations. Dhaka Univ. J. Pharm. Sci. 20(2): 199-211, 2021 (December)

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Section: Introductionmentioning

confidence: 99%

Evaluation of in vitro Dissolution Profile and Physicochemical Characterization of Polymer Based Formulations of Sparingly Soluble Rosuvastatin

Sikdar

Nazir

Alam

et al. 2021

Dhaka Univ. J. Pharm. Sci

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“…Pulse combustion is a periodic combustion process, and the pressure, temperature, flow rate, heat release etc cyclical changes in the combustion zone compared with conventional continuous combustion [1][2][3] Pulse combustors are classified by three types, such as Helmholtz-type, Schmidt-type and Rijke tubes, and the Helmholtz-type are applied widely.…”

Section: Introductionmentioning

confidence: 99%

Combustion Characteristics of a Helmholtz-Type Valveless Self-Excited Pulse Combustor

Qian¹,

2013

AMM

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Combustion characteristics of a Helmholtz-type valveless self-excited pulse combustor with continuous supply of gas and air were studied. The physical and mathematical models are established based on the actual pulse combustor, and the combustion characteristics are simulated with CFD. The results show that the possible re-ignition sources for the pulse combustion may be three. The first source may be the hot remnant gas near gas/air mixture. The second re-ignition source may be the high-temperature combustion chamber wall. The third ignition source is the unburned mixture. The pressure, temperature and mass fraction of propane in the combustion chamber have the phase relations and the combustion process stimulates the acoustic oscillation.

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“…Pengaruh koformer dalam teknik kokristal ini menjadi faktor penentu sehingga diperlukan desain kokristal terlebih dahulu dengan virtual screening tools yang bertujuan untuk melihat ikatan hidrogen yang terbentuk diantara dua atau lebih molekul yaitu BAF dengan koformer sehingga pembentukan kokristal dapat diprediksikan 6 .…”

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Artikel Review : Kokristal Ibuprofen dengan Berbagai Koformer, Virtual Screening Tools

2020

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Kokristal merupakan metode modifikasi suatu bahan obat dengan salah satunya penambahan gugus hidrogen antara bahan aktif farmasi dengan koformer. Dalam kurun waktu 10 tahun terakhir banyak BAF yang meningkat kelarutan seperti halnya ibuprofen. Namun dalam pelaksanaanya hasil peningkatan kelarutan ibuprofen dengan koformer lain lebih bervariasi karena pengaruh dari koformer. Pengaruh koformer dalam teknik kokristal ini menjadi faktor penentu sehingga diperlukan desain kokristal terlebih dahulu dengan virtual screening tools. Artikel tinjauan ini dibuat dengan metode instrumen pencarian online terbitan nasional ataupun internasional yang akan membahas sejarah kokristal, definisi kokristal, koformer untuk kokristal, teknik pembuatan kokristal, karakterisasi kokristal, pengaruh koformer pada perbedaan peningkatan kelarutan dari kokristal ibuprofen dan desain kokristal melalui virtual screening tools. Perbedaan peningkatan kelarutan dari kokristal ibuprofen dengan berbagai koformer diakibatkan oleh polaritas dari setiap koformer yang berbeda sehingga afinitas terhadap airnya pun berbeda. Pemilihan kofomer melalui metode virtual screening tools agar dapat melihat adanya ikatan hidrogen antara bahan aktif farmasi dengan koformer sehingga dapat digunakan untuk memprediksi pembentukan kokristal.

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Improvement of dissolution rate of ibuprofen by solid dispersion systems with Kollicoat IR using a pulse combustion dryer system

Cited by 10 publications

References 23 publications

Evaluation of in vitro Dissolution Profile and Physicochemical Characterization of Polymer Based Formulations of Sparingly Soluble Rosuvastatin

Evaluation of in vitro Dissolution Profile and Physicochemical Characterization of Polymer Based Formulations of Sparingly Soluble Rosuvastatin

Combustion Characteristics of a Helmholtz-Type Valveless Self-Excited Pulse Combustor

Artikel Review : Kokristal Ibuprofen dengan Berbagai Koformer, Virtual Screening Tools

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