Improvement of Drug Release Rate from Carbopol 934P Formulation.

Nakanishi, Takeshi; Kaiho, Fusao; Hayashi, Masahiro

doi:10.1248/cpb.46.171

Cited by 22 publications

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“…Improvement of drug release rate from carbopol 934P formulation: Nakanishi T, Kaiho F and Hayashi M having finding that, the carboxyl group of Carbopol is dissociate in the alkaline environment, electrostatic repulsion between negatively charged carboxyl groups causes uncoiling and expansion of molecules resulting in swelling of the polymer and gel formation. The gel is composed of closely packed swollen particles, whose swelling increases with increase in the pH; thus forming thicker and more rigid gel layer 6 . Aminophylline bio adhesive tablets attempted by wet granulation 7 the wet granulation has limited bio adhesion, because wetting of Carbomer and there drying was impossible when their concentration exceed 10 %.…”

Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Stability Studies on Nutraceuticals in Oral Solid Dosage Forms With Special Reference to Glucosamine

Merugu¹,

Reddy²,

Lala³

2013

Int. Res. J. Pharm.

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Pure Glucosamine is very "hygroscopic" and degrades (breaks down) rapidly when exposed to moisture or air. To avoid this, Glucosamine needs to be bound to a stabilizer to be sold commercially. The sulfate and the HCL forms are two of the most common "agents" that Glucosamine is bound to ensure its stability. After Glucosamine is bound, it is stable and will not degrade before it can get to the store shelf. Hence it is very difficult to prepare Glucosamine base and instead find Glucosamine Sulfate or Glucosamine HCL. Thus an attempt was made to stabilize the Glucosamine formulation by using the combination of anti-oxidant, Desiccant to resolve the problems associated with the Glucosamine formulation. In the present formulation studies were carried for the stability studies as ICH guidelines with Real time and Accelerated stability studies and it was found to be stable during the study period of stability for three months. All the formulas with single desiccant and single ant-oxidant did not reduce the extent of the degradation. The tablets so prepared with conventional methods showed good results physical evaluation parameters and chemical parameters such as Assay and Dissolution values. The granules prepared by using these ant-oxidants and desiccant, were good in their flow properties. Glucosamine, an amino monosaccharides naturally occurring in the connective and cartilage tissues, contributes to maintaining the strength, flexibility and elasticity of these tissues. Glucosamine is a precursor to a molecule called a glycosaminoglycan, which is used in the formation and repair of cartilage. In recent years, glucosamine has been used widely to treat osteoarthritis in humans and animal models. In vivo, glucosamine is typically converted to N-acetyl-glucosamine. Non-steroidal anti-inflammatory drugs (NSAIDS) are effective in reducing inflammation but are not highly soluble and, in addition, may have undesirable side effects. Efforts have been made to improve the pharmaceutical properties of NSAIDs, such as permeability, solubility and stability, by creating NSAID prodrugs. Prodrugs are typically evaluated in relation to the drug’s pharmacological and pharmacokinetic properties. These modifications may alter the physicochemical properties of the drug, which may in turn effect the administration options that optimize drug delivery

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Section: Introductionmentioning

confidence: 99%

Evaluation of in Vitro Stability Studies on Nutraceuticals in Oral Solid Dosage Forms With Special Reference to Glucosamine

Merugu¹,

Reddy²,

Lala³

2013

Int. Res. J. Pharm.

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“…In the realm of pharmaceutical formulation, several polyelectrolytes (PE) carrying acidic groups are currently used, mainly as suspending or viscosity‐increasing agents in liquid and semisolid formulations1 as well as in components of solid matrices 2–4. Although less attention has been given to the use of acidic PE as carriers of basic drugs, there is increasing interest in their application in this field 5–9.…”

Section: Introductionmentioning

confidence: 99%

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Jiménez-Kairuz

Allemandi

Manzo

2002

Journal of Pharmaceutical Sciences

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“…Gellan gum (GG) is a linear, anionic exopolysaccharide produced by a non-pathogenic strain of Sphinogomonas elodea . The chain of GG consists of four repeating units of carbohydrate, which include α- l -rhamnose, β- d -glucose, and β- d -glucuronate, in a 1:2:1 molar ratio [ 96 ], whereas Carbopol 934P is a mucoadhesive polymer that has been investigated as a useful adjuvant for bioadhesive drug delivery systems [ 97 ]. Carbopol 934P belongs to a polyacrylic acid resin family known as the carbomers, which is a suitable candidate for usage in drug delivery systems.…”

Section: Hydrogelsmentioning

confidence: 99%

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

et al. 2020

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Periodontitis (PD) is a chronic inflammatory disease of periodontal tissues caused by pathogenic microorganisms and characterized by disruption of the tooth-supporting structures. Conventional drug administration pathways in periodontal disease treatment have many drawbacks such as poor biodistribution, low selectivity of the therapeutic effect, burst release of the drug, and damage to healthy cells. To overcome this limitation, controlled drug delivery systems have been developed as a potential method to address oral infectious disease ailments. The use of drug delivery devices proves to be an excellent auxiliary method in improving the quality and effectiveness in periodontitis treatment, which includes inaccessible periodontal pockets. This review explores the current state of knowledge regarding the applications of various polymer-based delivery systems such as hydrogels, liposomes, micro-, and nanoparticles in the treatment of chronic periodontal disease. Furthermore, to present a more comprehensive understanding of the difficulties concerning the treatment of PD, a brief description of the mechanism and development of the disease is outlined.

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Improvement of Drug Release Rate from Carbopol 934P Formulation.

Cited by 22 publications

References 0 publications

Evaluation of in Vitro Stability Studies on Nutraceuticals in Oral Solid Dosage Forms With Special Reference to Glucosamine

Evaluation of in Vitro Stability Studies on Nutraceuticals in Oral Solid Dosage Forms With Special Reference to Glucosamine

Mechanism of Lidocaine Release From Carbomer–Lidocaine hydrogels

Polymeric Carriers for Delivery Systems in the Treatment of Chronic Periodontal Disease

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