Improvement of dyslipidemia, insulin sensitivity, and energy balance by a peroxisome proliferator–activated receptor α agonist

Chen, Xiaoli; Matthews, Jay M.; Zhou, Lubing; Pelton, Patricia D.; Liang, Yin; Xu, Jun; Yang, Maria; Cryan, Ellen V.; Rybczynski, Philip J.; Demarest, Keith T.

doi:10.1016/j.metabol.2008.06.005

Cited by 24 publications

(13 citation statements)

References 39 publications

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“…Gemfibrozil affects the prestin and Gata-3 expression via PPAR, a member of the nuclear receptor family. PPAR plays an important role in the regulation of genes involved in lipid metabolism and transport (Chen et al, 2008). This is important for the prestin function because the fluidity of the OHC lateral plasma membrane is regulated by cholesterol levels.…”

Section: Discussionmentioning

confidence: 99%

“…PPAR-alpha is also a member of the nuclear receptor family of ligand-activated transcription factors. PPARs are involved in regulation of lipid metabolism and transport (Chen et al, 2008). The lipid metabolism of the organ of Corti is important for the prestin function because the fluidity of the OHC lateral plasma membrane is regulated by cholesterol levels (Organ and Raphael, 2009).…”

Section: Introductionmentioning

confidence: 99%

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Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture

et al. 2010

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture

et al. 2010

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“…[6][7][8] Senyawa SFA pada jaringan adiposit akan bekerja meningkatkan Peroxisome Proliferator Activated Receptor-γ (PPAR-γ) sehingga FFA yang berlebih diesterifikasi menjadi trigliserida (TG). 9 Kompetisi antara ALJ dan ALJRS dalam mengatur faktor transkripsi pada inti sel akan terlihat pada profil lemak darah atau enzim yang terkait pada metabolisme lemak. MS kaya akan ALJ dan ALTJ, sedangkan MK kaya ALJRS dan sedikit mengandung ALTJ (1,7%).…”

Section: Pendahuluanunclassified

Pengaruh Diet Tinggi Minyak Kelapa Dan Minyak Sawit Terhadap Profil Lemak Darah Tikus

Sastri¹

2015

MKA

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AbstrakProfil lemak darah ikut ditentukan oleh jenis dan proporsi asam lemak dalam minyaksawit dan minyak kelapa yang dikonsumsi. Kandungan asam lemak tak jenuh (ALTJ) danasam lemak jenuh (ALJ) dalam minyak sawit hampir sama banyak, sedangkan minyakkelapa kaya akan asam lemak jenuh rantai sedang (ALJRS) yang mudah dirubah menjadienergi. Tujuan penelitian ini adalah untuk menentukan pengaruh diet tinggi minyak sawitdan minyak kelapa terhadap profil lemak darah tikus putih jantan galur Wistar. Penelitiandilakukan melalui pemberian diet tinggi minyak sawit (DMS) dan diet tinggi minyak kelapa(DMK) terhadap tikus jantan Wistar putih selama 8 minggu adlibitum. Profil lemak darah diukurdengan spektrofotometer. Data diolah secara non-parametrik dengan p<0,05. Hasil penelitianmenunjukkan DMS dan DMK meningkatkan profil lemak darah bermakna dibandingkan kontrol.Kelompok DMK meningkatkan dengan bermakna kolesterol total (p=0,047), HDL-kolesterol(p=0,009) dan rasio HDL-kolesterol/kolesterol total (p=0,009). Kelompok DMS meningkatkantrigliserida (p=0,076) tetapi tidak bermakna, sedangkan fraksi non-HDL-kolesterol meningkatbermakna (p=0,009). Diet tinggi minyak kelapa pada tikus meningkatkan kadar kolesteroltotal dan HDL-kolesterol, sedangkan diet tinggi minyak sawit meningkatkan fraksi non-HDLkolesterol.AbstractBlood lipid profiles were determined by the types and proportion of fatty acids contained bycoconut and palm oil which is consumed. The proportion of unsaturated fatty acids (UFA) andsaturated fatty acids of palm oil is almost balanced, while coconut oil is rich with medium chainsaturated fatty acids (MCSFA), which is easily converted into energy. This study determinedthe effect of consumption of palm oil and coconut oil on blood lipid profiles of male white Wistarrats. This was an experimental study. High palm oil and coconut oil diet were given to male whiteWistar rats ad libitum for eight weeks. Blood lipid profiles were measured by spectrofotometer.The data was analized using nonparametric tests with p<0,05. Results showed that high dietof palm oil and coconut oil altered blood lipid profiles. High coconut oil diet increased thetotal cholesterol (p=0,047), HDL-cholesterol (p=0,009), and HDL-cholesterol/total cholasterol(p=0,009). High palm oil diet increased triglycerides (p=0,076) unsignificantly, whereas thefraction of non-HDL-cholesterol increased significantly (p=0,009). The conclusion of this studywas that high diet of coconut oil in rats increased total cholesterol and HDL-cholesterol, whilethe high diet of palm oil increased non-HDL-cholesterol.

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“…PPAR is mainly expressed in adipose tissue; so metabolic effects are thought to result from direct action on the adipose tissue and secondary impact in liver and skeletal muscle. The beneficial effects of PPAR agonists on m uscle, li ver, and ve ssels a re mediated by their ability to improve insulin-mediated uptake and metabolism of gl ucose and NE FA in the adipocytes, to induce the produc tion of a diponectin, and t o re duce produc tion of adipocyte-derived fa ctors l eading t o i nsulin re sistance (resistin, T NF and inflammatory molecules) [129,130]. It h as been a lso d emonstrated that experimental drugs w ith dua l activation of P PAR a nd h ave p otential f or u se in the treatment of various aspects of metabolic dysfunction in type 2 di abetes that i nclude dys lipidemia, hype rglycemia, a nd hyperinsulinaemia [131].…”

Section: Other Investigational and New Drugsmentioning

confidence: 99%

Obesity: Pathophysiology and Clinical Management

Gurevich-Panigrahi¹,

Panigrahi²,

Wiecheć³

et al. 2009

CMC

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Obesity is a serious socioeconomic, and also increasingly clinical problem. Between -1 / 3 of population in the developed countries can be classified as obese. Four major etiological factors for development of obesity are genetic determinants, environmental fac tors, f ood i ntake a nd exercise. O besity i ncreases the risk of t he de velopment of v arious pathologic conditions including: insulin-resistant di abetes m ellitus, cardiovascular disease, non-alcoholic fatty l iver di sease, endocrine problems, and certain forms of cancer. Thus, obesity is a negative prognostic factor for longevity. In this review w e pr ovide br oad ove rview of pa thophysiology of obe sity w e a lso di scuss va rious a vailable, a nd e xperimental therapeutic methods. We also highlight functions of adipocytes including fat storing capacity and secretory activity resulting in numerous endocrine effects like leptin, IL-6, adiponectin, and resistin. The anti-obesity drugs are classified according to their primary action on energy balance. Major classes of these drugs are: appetite suppressants, inhibitors of fat absorption (i.e. orlistat), stimulators of thermogenesis and stimulators of fat mobilization. The appetite suppressants are further divided into noradrenergic agents, (i.e. phentermine, phendimetrazine, benzphetamine, diethylpropion), serotoninergic agents (i.e. dexfenfluramine), and mixed noradrenergic-serotoninergic agents (i.e. sibutramine). Thus, we highlight recent advances in the understanding of the central neural control of energy balance, current treatment strategies for obesity and the most promising targets for the development of novel anti-obesity drugs.

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Improvement of dyslipidemia, insulin sensitivity, and energy balance by a peroxisome proliferator–activated receptor α agonist

Cited by 24 publications

References 39 publications

Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture

Expression of prestin and Gata-3,-2,-1 mRNA in the rat organ of Corti during the postnatal period and in culture

Pengaruh Diet Tinggi Minyak Kelapa Dan Minyak Sawit Terhadap Profil Lemak Darah Tikus

Obesity: Pathophysiology and Clinical Management

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