Improvement of Endothelial Dysfunction with Simvastatin in Patients with Autosomal Dominant Polycystic Kidney Disease

Namli, Sule; Oflaz, Hüseyin; Turgut, Faruk; Alışır, Sabahat; Tufan, Fatih; Uçar, Adem; Mercanoğlu, Fehmi; Ecder, Tevfik

doi:10.1080/08860220601038892

Cited by 32 publications

(19 citation statements)

References 31 publications

(33 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Several studies have suggested a beneficial effect of statins on endothelial function, renal blood flow, and levels of interleukin-6 and C-reactive protein 134. Administration of lovastatin to cy/ + rats increased renal blood flow and ameliorated the renal cystic disease, but the beneficial effects from the administration lovastatin and enalapril on the severity of the cystic disease were not additive 135…”

Section: Treatmentmentioning

confidence: 99%

Autosomal dominant polycystic kidney disease: the last 3 years

Torres

Harris

2009

Kidney International

523

449

View full text Add to dashboard Cite

Autosomal dominant polycystic kidney disease is the most prevalent, potentially lethal monogenic disorder. It has large inter- and intra-familial variability explained to a large extent by its genetic heterogeneity and modifier genes. An increased understanding of its underlying genetic, molecular, and cellular mechanisms and a better appreciation of its progression and systemic manifestations have laid out the foundation for the development of clinical trials and potentially effective therapies. The purpose of this review is to update the core of knowledge in this area with recent publications that have appeared during 2006–2009.

show abstract

Section: Treatmentmentioning

confidence: 99%

Autosomal dominant polycystic kidney disease: the last 3 years

Torres

Harris

2009

Kidney International

523

449

View full text Add to dashboard Cite

show abstract

“…24 Endothelial function also is impaired in patients with ADPKD as compared with patients with essential hypertension and normal control subjects. 25 In this regard, angiotensin II stimulates oxygen radicals, which may exert deleterious effects on the integrity of the endothelium. 26 Thus, the pathogenesis of hypertension in patients with ADPKD, which most frequently occurs before any clinically relevant loss of renal function, is multifactorial (Figure 4).…”

Section: Sympathetic Activity In Adpkdmentioning

confidence: 99%

Renal Volume, Renin-Angiotensin-Aldosterone System, Hypertension, and Left Ventricular Hypertrophy in Patients with Autosomal Dominant Polycystic Kidney Disease

Schrier¹

2009

Journal of the American Society of Nephrology

126

106

View full text Add to dashboard Cite

In the past, autosomal dominant polycystic kidney disease (ADPKD) had been termed adult polycystic disease. Now, however, it is clear that many of the features of ADPKD occur during childhood. In fact, ADPKD has been diagnosed in utero. 1 Very-early-onset ADPKD has been the designation for infants whose diagnosis is made within the first 18 mo of life. 2 As compared with children who receive a diagnosis of ADPKD later, the children with very-early-onset ADPKD have larger kidneys and more renal cysts when adjusted for age. 3 CHILDREN WITH ADPKDThe most consistent characteristic of children with ADPKD is the relationship between renal volume and BP. Children with ADPKD and hypertension, defined as Ͼ95th percentile, have significantly larger kidneys than children who have ADPKD and have BP Ͻ95th percentile. 4 Children with BP between the 75th and 95th percentiles have been designated as having borderline hypertension, whereas BP Ͻ75th percentile is designated as normotension. 4 Children who have ADPKD and either hypertension or borderline hypertension exhibit a left ventricular mass index (LVMI) that is significantly greater than in children with normotension. Children who have ADPKD with hypertension have the largest kidneys by ultrasonography, and there is a highly significant correlation in renal volume with systolic as well as diastolic BP. 4 In a prospective 5-yr follow-up study, children with ADPKD and hypertension demonstrated a progressive increase in renal volume and LVMI. 5 During this 5-yr follow-up, 52% of the children with borderline hypertension developed frank hypertension. Of interest, in contrast to children who have ADPKD with hypertension, who needed more than one antihypertensive agent, the BP in children with borderline hypertension could be well controlled to Ͻ50th percentile by monotherapy with an angiotensin-converting enzyme inhibitor ABSTRACTThe relationship between renal volume and hypertension in autosomal dominant polycystic kidney disease (ADPKD) occurs in childhood. Hypertension is associated not only with increased kidney volume but also with significantly increased left ventricular mass index. Moreover, this increase in left ventricular mass index occurs in children who have ADPKD with borderline hypertension (75th to 95th percentile) and is prevented with angiotensin-converting enzyme inhibitor (ACEI) monotherapy. Progression from borderline to overt hypertension (Ն95th percentile) occurs during a 5-yr follow-up in approximately 50% of children with ADPKD and borderline hypertension. Renal cyst enlargement in ADPKD in adults is associated with stimulation of both the circulating and intrarenal renin-angiotensin-aldosterone system. In addition to hypertension, the resultant angiotensin in ADPKD is a pivotal factor in cyst proliferation and expansion, increased sympathetic and endothelin activity, oxidant injury, and fibrosis. There is a close correlation between the level of hypertension, left ventricular hypertrophy, deterioration of GFR, and the progressive enlargement of the cys...

show abstract

“…Activation of the intrarenal renin-angiotensin system may be associated with progression in ADPKD (10), and treatment with angiotensinconverting enzyme inhibitors (ACEIs) has been shown to reduce proteinuria and reduce the left ventricular mass index (LVMI) in patients with ADPKD (11,12). Statins may also have beneficial effects in ADPKD (13), and several ongoing clinical trials are investigating various strategies to slow disease progression in ADPKD (14).…”

mentioning

confidence: 99%