Improvement of Gastric Motility with Gastric Electrical Stimulation in STZ-Induced Diabetic Rats

Liu, Jinsong; Qiao, Xuguang; Micci, Maria Adelaide; Pasricha, Pankaj J.; Chen, J. D.Z.

doi:10.1159/000081516

Cited by 104 publications

(133 citation statements)

References 38 publications

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“…It seems that a single channel GES with long pulses has no effects on gastric emptying in healthy dogs but is capable of improving gastric emptying in a canine model of gastroparesis and a rodent model of diabetes. 29,34,50 Whereas, two-or four-channel GES with long pulses is able to improve gastric emptying in both healthy and diseased model of canines; 21,22 similar results (improvement in liquid and solid gastric emptying) were also observed with a multi-channel sequential GES of trains of pulses with a pulse width in the order of a few milliseconds. 23,24 GES with long pulses showed similar improvement in gastric emptying in patients with gastroparesis.…”

Section: Gastric Emptyingmentioning

confidence: 66%

“…GES with long pulse/low frequency was reported to normalize vasopressin-or glucagon-induced gastric dysrhythmia and slow wave uncoupling in dogs and dysrhythmia in a rodent model of diabetes. [33][34][35][36] Normalization of dysrhythmia was also reported in patients with gastroparesis and postsurgical patients using the same method of GES. 37,38 While the exact mechanisms involved in the normalization of gastric dysrhythmia with long pulse/low frequency GES are unclear, it is known that it does not involve the vagal or cholinergic pathway.…”

Section: Alterations Of Gastric Slow Wavesmentioning

confidence: 69%

“…It was found that GES with long pulses was capable of normalizing gastric dysrhythmia, improving gastric emptying and reducing gastroparetic symptoms. 37 The improvement in gastric slow waves and gastric emptying was supported by the controlled animal studies, 29,[33][34][35][36] whereas, the improvement in symptoms was not demonstrated in the canine studies. 36 It was therefore, unclear whether the improvement in gastroparetic symptoms was attributable to the direct effects of GES or to the overall improvement in clinical profile of the patients.…”

Section: Ges With Long Pulsesmentioning

confidence: 97%

See 2 more Smart Citations

Systematic review: applications and future of gastric electrical stimulation

Zhang

Chen

2006

Aliment Pharmacol Ther

106

114

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Section: Gastric Emptyingmentioning

confidence: 66%

Section: Alterations Of Gastric Slow Wavesmentioning

confidence: 69%

Section: Ges With Long Pulsesmentioning

confidence: 97%

See 1 more Smart Citation

Systematic review: applications and future of gastric electrical stimulation

Zhang

Chen

2006

Aliment Pharmacol Ther

106

114

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“…STZ-diabetes results in slower gastric motility (30) and gastric retention (32), a trend evident in our sham-operated groups. Accordingly, insulin-induced gastric motility (44) and acid secretion (18) are abolished by HV.…”

Section: Ajp-endocrinol Metabmentioning

confidence: 73%

The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats

Warne

Foster²,

Horneman³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Warne JP, Foster MT, Horneman HF, Pecoraro NC, de Jong HK, Ginsberg AB, Akana SF, Dallman MF. The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats. Am J Physiol Endocrinol Metab 294: E190-E200, 2008. First published October 30, 2007 doi:10.1152/ajpendo.00336.2007.-The common hepatic branch of the vagus nerve negatively regulates lard intake in rats with streptozotocin (STZ)-induced, insulin-dependent diabetes. However, this branch consists of two subbranches: the hepatic branch proper, which serves the liver, and the gastroduodenal branch, which serves the distal stomach, pancreas, and duodenum. The aim of this study was to determine whether the gastroduodenal branch specifically regulates voluntary lard intake. We performed a gastroduodenal branch vagotomy (GV) on nondiabetic, STZ-diabetic, and STZ-diabetic insulin-treated groups of rats and compared them with sham-operated counterparts. All rats had high steady-state corticosterone levels to maximize lard intake. Five days after surgery, all rats were provided with the choice of chow or lard to eat for another 5 days. STZ-diabetes resulted in a reduction in lard intake that was partially rescued by either GV or insulin treatment. Patterns of white adipose tissue (WAT) deposition differed after GV-and insulininduced lard intake, with subcutaneous WAT increasing exclusively after the former and mesenteric WAT increasing exclusively in the latter. GV also prevented the insulin-induced reduction in the STZelevated plasma glucagon, triglycerides, free fatty acids, and total ketone bodies but did not alter the effect of insulin-induced reduction of plasma glucose levels. These data suggest that the gastroduodenal branch of the vagus inhibits lard intake and regulates WAT deposition and plasma metabolite levels in STZ-diabetic rats.insulin; glucocorticoids; obesity; diabetes; food intake THE COMMON HEPATIC BRANCH of the vagus nerve consists of fibers directly serving the liver parenchyma, bile ducts, and portal vein, collectively called the hepatic branch proper, with those serving the duodenum, pancreas, pylorus, and distal gastric antrum, collectively known as the gastroduodenal branch (6). Signaling through the common hepatic branch is important in energy metabolism since the fibers are sensitive to a variety of hormonal and metabolic stimuli (4), including carbohydrates (33), fats (42), and amino acids (51).When rats are presented with the choice of lard and chow to consume, the total number of calories ingested is influenced by prevailing corticosterone levels, whereas insulin influences the composition of calories ingested (26,40). Specifically for insulin, streptozotocin (STZ)-induced insulin-dependent diabetes reduces lard intake to favor chow, a situation that is reversed by exogenous insulin treatment (26,54,56). STZ-diabetes also results in behavioral, autonomic, endocrine, and neuroendocrine characteristics of chronic stress in rodents (47). Hence, the...

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“…Long-pulse GES is capable of entraining (pacing) physiological electrical activity of the stomach in both animals and humans (7, 17, 18, 20, 24). Single-channel GES with long pulses has no effects on gastric emptying in healthy dogs but is capable of improving gastric emptying in a canine model of gastroparesis and a rodent model of diabetes (5,11,22). Whereas two-or four-channel GES with long pulses is able to improve gastric emptying in both healthy and diseased models of canines (8,32), similar results (improvement in liquid and solid gastric emptying) were also observed with multichannel sequential GES of trains of pulses with pulse width in the order of a few milliseconds (25,26).…”

Section: Discussionmentioning

confidence: 99%

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

Zhu¹,

Sallam²,

Chen³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

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The aim of this study was to determine the effects and mechanism of synchronized gastric electrical stimulation (SGES) on gastric contractions and gastric emptying. The first experiment was designed to study the effects of SGES on antral contractions in four randomized sessions. Sessions 1 (control) and 2 (atropine) were performed in the fasting state, composed of three 30-min periods (baseline, stimulation, and recovery). Sessions 3 (control) and 4 (SGES performed during 2nd 20-min period) were performed in the fed state, consisting of two 20-min periods; glucagon was injected after the first 20-min recording. The second experiment was designed to study the effect of SGES on gastric emptying and consisted of two sessions (control and SGES). SGES was delivered with train duration of 0.5–0.8s, pulse frequency of 40 Hz, width of 2 ms, and amplitude of 4 mA. We found that 1) SGES induced gastric antral contractions in the fasting state. The motility index was 1.3 ± 0.5 at baseline and 6.1 ± 0.7 ( P = 0.001) during SGES. This excitatory effect was completely blocked by atropine. 2) SGES enhanced postprandial antral contractions impaired by glucagon. 3) SGES significantly accelerated glucagon-induced delayed gastric emptying. Gastric emptying was 25.5 ± 11.3% without SGES and 38.3 ± 10.7% with SGES ( P = 0.006 vs. control). This novel method of SGES induces gastric antral contractions in the fasting state, enhances glucagon-induced antral hypomotility in the fed state, and accelerates glucagon-induced delayed gastric emptying. The effect of SGES on antral contractions is mediated via the cholinergic pathway.

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Improvement of Gastric Motility with Gastric Electrical Stimulation in STZ-Induced Diabetic Rats

Cited by 104 publications

References 38 publications

Systematic review: applications and future of gastric electrical stimulation

Systematic review: applications and future of gastric electrical stimulation

The gastroduodenal branch of the common hepatic vagus regulates voluntary lard intake, fat deposition, and plasma metabolites in streptozotocin-diabetic rats

Therapeutic potential of synchronized gastric electrical stimulation for gastroparesis: enhanced gastric motility in dogs

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