Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

Lu, Chun‐Fu; Huang, Chiung Chun; Wang, Szu-Hsuan; Chiu, Chien Chao; Li, Lan Hui; Hua, Kuo Feng; Wu, Tzong–Lin

doi:10.1016/j.cbi.2018.05.004

Cited by 12 publications

(6 citation statements)

References 45 publications

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“…The study by Lu et al. shows high glucose (25 mM) induced the increased expression of IL-1 but not COX-2 in macrophages, indicating that the change of Cox-2 expression in response to high glucose might vary with the cell type and glucose concentration . Our results also showed that PDTC as well as C3G pretreatment inhibited the high glucose-induced Cox-2 expression via their inhibitory effect on NF-κB activation, as mentioned above.…”

Section: Discussionsupporting

confidence: 78%

“…21−23 However, Cox-2 expression in LECs under high glucose conditions and its role in pathogenesis of diabetic cataract was not examined previously. Our results showed that the expression of Cox-2 in SRA01/04 cells was 24 Our results also showed that PDTC as well as C3G pretreatment inhibited the high glucose-induced Cox-2 expression via their inhibitory effect on NF-κB activation, as mentioned above. The Bcl-2 family is well-known for their crucial roles in regulating cell apoptosis.…”

Section: ■ Discussionsupporting

confidence: 76%

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Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression

Song

et al. 2020

J. Agric. Food Chem.

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Diabetic cataract is one of the most important causes of blindness worldwide. Cyanidin-3-O-glucoside (C3G) is found to exert beneficial effects on many diabetic complications. However, its effect on diabetic cataract is not well known. Herein, we investigated the effect of C3G on high glucose-induced lens epithelial cell (SRA01/04) apoptosis and cataract formation as well as the involved mechanisms. We found C3G (20 μM) could preserve cell viability in SRA01/04 cells exposed to high glucose (100 μM). Meanwhile, C3G inhibited SRA01/04 cell apoptosis and regulated the Bcl-2/Bax ratio. Additionally, C3G suppressed NF-κB activation and subsequent cyclooxygenases-2 (Cox-2) expression, which are associated with the protection against apoptosis. Moreover, C3G attenuated lens opacity and protein aggregation in lens culture exposed to high glucose. In conclusion, C3G protected against high glucose-induced SRA01/04 cell apoptosis and cataract formation, which indicated the potential protection of anthocyanins on diabetic cataract.

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Section: Discussionsupporting

confidence: 78%

Section: ■ Discussionsupporting

confidence: 76%

Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression

Song

et al. 2020

J. Agric. Food Chem.

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“…Silymarin down‐regulated interleukin 1β (ΙL‐1β) secretion and decreased LPS‐induced ERK1/2 phosphorylation in both normal glucose and high glucose‐cultured RAW 264.7 macrophages. However, silymarin did not affect NF‐κB activation in these cells (Lu et al, 2018). In another study, silymarin attenuated cigarette smoke extract‐induced inflammation in human bronchial epithelial cells through inhibiting autophagy and ERK/p38 MAPK pathway (Li et al, 2016).…”

Section: Experimental Studiesmentioning

confidence: 99%

Polyphenols: Potential anti‐inflammatory agents for treatment of metabolic disorders

Zamani-Garmsiri

Emamgholipour

Fard

et al. 2021

Phytotherapy Research

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Ample evidence highlights the potential benefits of polyphenols in health status especially in obesity‐related metabolic disorders such as insulin resistance, type 2 diabetes, and cardiovascular diseases. Mechanistically, due to the key role of “Metainflammation” in the pathomechanism of metabolic disorders, recently much focus has been placed on the properties of polyphenols in obesity‐related morbidities. This narrative review summarizes the current knowledge on the role of polyphenols, including genistein, chlorogenic acid, ellagic acid, caffeic acid, and silymarin in inflammatory responses pertinent to metabolic disorders and discusses the implications of this evidence for future directions. This review provides evidence that the aforementioned polyphenols benefit health status in metabolic disorders via direct and indirect regulation of a variety of target proteins involved in inflammatory signaling pathways. However, due to limitations of the in vitro and in vivo studies and also the lack of long‐term human clinical trials studies, further high‐quality investigations are required to firmly establish the clinical efficacy of the polyphenols for the prevention and management of metabolic disorders.

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“…Studies have shown that coenzyme Q10 and carnosine can increase the level of insulin, carnosine can promote the secretion of insulin [97], and coenzyme Q10 can promote the synthesis and secretion of insulin [109]. Vitamin E, sele-nium, zinc, resveratrol, silymarin, probucol, and crocin can help improve insulin, vitamin E can improve insulin resistance and insulin sensitivity [110], selenium can improve insulin sensitivity [111], zinc can regulate insulin receptor, which is an insulin-like substance [112,113], silymarin can improve insulin resistance [114], and resveratrol can increase insulin sensitivity [115] and improve insulin resistance. Probucol can improve blood glucose levels in insulin-resistant mouse models [116].…”

Section: Subgroup Analysismentioning

confidence: 99%

Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment

et al. 2023

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Diabetic kidney disease (DKD) is more prevalent with an increase in diabetes mellitus. Oxidative stress is a major factor in the occurrence and progression of DKD. Defending against oxidative stress and restoring antioxidant defense might be key to preventing and treating DKD. The purpose of this article is to provide an explanation of how oxidative stress affects DKD, conduct a systematic review and meta-analysis on DKD, and examine the effect of antioxidants on the disease. An analysis of 19 randomized controlled trials showed that the use of antioxidants could reduce UAE (albumin excretion rate) in patients with DKD (SMD: − 0.31; 95% CI [− 0.47, − 0.14], I2 = 0%), UACR (urine albumin/creatinine ratio) (SMD: − 0.60; 95% CI [− 1.15, − 0.06], I2 = 89%), glycosylated hemoglobin (hbA1c) (MD: − 0.61; 95% CI [− 1.00, − 0.21], I2 = 93%) and MDA (malonaldehyde) (SMD:-1.05; 95% CI [− 1.87, − 0.23], I2 = 94%), suggesting that antioxidants seemed to have therapeutic effects in patients with DKD, especially in reducing proteinuria and hbA1c. The purpose of this study is to provide new targets and ideas for drug research and clinical treatment of DKD.

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Improvement of hyperglycemia in a murine model of insulin resistance and high glucose- and inflammasome-mediated IL-1β expressions in macrophages by silymarin

Cited by 12 publications

References 45 publications

Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression

Cyanidin-3-O-glucoside Protects Lens Epithelial Cells against High Glucose-Induced Apoptosis and Prevents Cataract Formation via Suppressing NF-κB Activation and Cox-2 Expression

Polyphenols: Potential anti‐inflammatory agents for treatment of metabolic disorders

Effects of antioxidants on diabetic kidney diseases: mechanistic interpretations and clinical assessment

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