Improvement of Hypothyroidism after Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity

Raftopoulos, Yannis; Gagné, Daniel J.; Papasavas, Pavlos; Hayetian, Fernando; Maurer, J.; Bononi, Patricia; Caushaj, Philip F.

doi:10.1381/096089204323013514

Cited by 76 publications

(49 citation statements)

References 16 publications

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“…Thyroid hormones regulate energy metabolism and affect fat distribution, body weight, and metabolic disorders (4,5). Hypothyroidism is associated with a risk of developing metabolic syndrome, and several groups have shown the relationship between hypothyroidism and NAFLD and hypothyroidism and NASH (6)(7)(8)(9)(10).…”

Section: Introductionmentioning

confidence: 99%

Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease

et al. 2016

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Abstract3,5,3'-triiodo-L-thyronine regulates the glucose metabolism, lipid metabolism, and hepatic steatosis. Several groups have shown the relationships between hypothyroidism and nonalcoholic fatty liver and hypothyroidism and nonalcoholic steatohepatitis (NASH). However, the effect of hyperthyroidism on NASH has not yet been investigated. We herein report effects of thyroid hormone on the pathological condition of NASH in a patient with NASH complicated by Graves' disease. In our case, the liver enzyme level improved with the increasing thyroid hormone level; however, the liver enzyme level was aggravated with the improving thyroid hormone level. Therefore, hyperthyroidism may improve the pathological condition of NASH.

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Section: Introductionmentioning

confidence: 99%

Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease

et al. 2016

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“…Raftopoulos' series [5] reported that post-LRYGB hypothyroidism improved and thyroxine requirements were reduced in 10 of the 23 patients (43.5%). Two of the 23 patients (8.7%) had complete resolution and the remaining 8 patients (34.8%) had reduction (14%-50%, median 33%) of their thyroxine requirements; 13 of the 23 patients (56.5%) had no change in their thyroxine requirements.…”

Section: Discussionmentioning

confidence: 99%

“…Improved thyroid status has been reported among obese patients following other bariatric surgical procedures [4][5][6][7][8][9][10][11][12], while few studies have been published on the effect of LSG on thyroid status [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

Effect of Laparoscopic Sleeve Gastrectomy on Clinical Hypothyroidism in Morbidly Obese Patients

Elnabil¹,

Ahmed²,

Mostafa³

2017

Thyroid Disorders Ther

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“…Gastric bypass seems to restore thyroid function in hypothyroid patients independently of final BMI [20][21][22][23], while gastric banding seems to reduce TSH levels, with no effect on fT3 and fT4 levels [23,24]. This phenomenon is often attributed to the loss in body weight, which seems to correlate to TSH levels; however, changes in the nutritional intake interfering with peripheral fT3 de-iodination and modifications of leptin concentrations seem to play a role in the decrease of TSH secretion.…”

Section: Discussionmentioning

confidence: 99%

Thyroid Function and Insulin Sensitivity Before and After Bilio-pancreatic Diversion

et al. 2009

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BPD increases the prevalence of subclinical or even frank hypothyroidism, without causing a defect in thyroid function itself, through several integrated mechanisms. (1) It induces iodine malabsorption, which is partially compensated by iodine excretion contraction. (2) The entero-hepatic open circulation determines fT3 loss, which induces subclinical or frank hypothyroidism in patients with pre-existing thyroid alterations, interfering also with the weight loss progress. Iodine supplementation should be recommended in those patients reporting thyroid alterations at the sonogram prior to BPD, LT4 therapy should be strictly monitored in patients suffering of subclinical hypopthiroidism and T3 therapy should eventually be considered for patients diagnosed with frank hypothyroidism prior to BPD.

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Improvement of Hypothyroidism after Laparoscopic Roux-en-Y Gastric Bypass for Morbid Obesity

Abstract: Improvement of hypothyroidism may be an additional benefit of bariatric surgery that has not been previously reported. Reduction of thyroxine requirements is most likely the result of the decrease in the BMI.

Cited by 76 publications

References 16 publications

Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease

Hyperthyroidism Improves the Pathological Condition of Nonalcoholic Steatohepatitis: A Case of Nonalcoholic Steatohepatitis with Graves' Disease

Effect of Laparoscopic Sleeve Gastrectomy on Clinical Hypothyroidism in Morbidly Obese Patients

Thyroid Function and Insulin Sensitivity Before and After Bilio-pancreatic Diversion

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