The study aimed to predict an etiologic pathology leading to some disease spread in females.Pelvic congestion syndrome (PCS) in females is a condition that is difficult to diagnose; a specific diagnosis for the condition is often difficult, no diagnosis is made in 60% of patients. Chronic pelvic pain (CPP) is a common and disabling condition affecting women of childbearing age; PCS is a recognized cause of CPP. Pelvic congestion and pelvic inflammatory conditions constitute the underlying etiology in a significant proportion of patients with CPP. Treatment of PCS is above all medical, based upon decongestive and anti-inflammatory agents. Abnormal colonic Helicobacter pylori strains have been shown to be responsible for the worst case of pelvic congestion due to accumulation of profuse toxic amounts of ammonia in the colon. Both colon clear and cupping were considered to have an effective therapeutic role in female PCS due to elimination of the underlying etiologic pathological elements (congestive and inflammatory) from the pelvis. The impact on life and the spread beyond traditional medical rules during last three decades of endometriosis, ovarian cystic disease and endometriotic ovarian cysts were considerable and obvious. 50 sexually active female patients with different forms of pelvic clinical presentations had been included in this study. They were 10 patients with pelvic pain, 10 patients with scanty menstruation, 10 patients with primary infertility, 10 patients with endometriosis and 10 patients with ovarian cystic disease. Pelvic and trans-vaginal Doppler ultrasound examinations were done routinely for all patients to assess any local pelvic pathology. All patients had undergone colon clear followed by a blood-let out therapy from the upper and lower back. Revision therapy was decided according to response of patients. All patients with pelvic pain and scanty menstruation were cured after a primary session or revision of therapy with colon clear and cupping therapy. 7 patients with primary infertility got pregnant after 3 sessions of combined colon clear and cupping therapy. All patients with endometriosis and ovarian cystic disease were relieved from their symptoms while most of them (9 with endometriosis and 7 with ovarian cystic disease) have reported after 3 consecutive sessions of colon clear and cupping therapy that their gynecology physicians have confirmed that they demonstrated stop of their disease progress.On conclusion, pelvic disease spread in females beyond traditional scientific rules could indicate the possibility of an existing missed underlying pathology. Screening of females with frank history of H. pylori dyspepsia may become a mandatory new health care requirement for early detection of female pelvic pathology.