Affect gas extraction efficiency to find out the optimum well location parameters, based on the gray correlation analysis of borehole diameter, borehole spacing, and extraction pressure three boreholes parameters that influence efficiency of gas extraction from the design of orthogonal experiment, using COMSOL simulate the effective radius of extraction under different experiments, and the effective radius of extraction for optimizing index quantitative gas extraction efficiency. The results showed that: factors affecting the gas extraction efficiency of the correlation between high and low aperture drilling, borehole spacing, and extraction from extraction negative pressure, it is concluded that the influence parameters of optimal layout parameter values, respectively, borehole diameter 8 cm and 3 m borehole spacing, extraction pressure 50 kPa, combined with the numerical simulation analysis using the optimal layout of gas drilling extraction from about 30 days. The decrease in gas pressure is about 45%, which basically meets the extraction standard, and the decreasing trend of gas pressure is obviously slowed down when the extraction time is longer than 30 days. The engineering experiment is carried out in the 9306 transport lane of a mine in Guizhou Province, and the results are basically consistent with the simulation results, which verify the rationality of the gray correlation analysis method to optimize the drilling parameters, and provide a theoretical basis for the optimization of drilling parameters.