Improvement of light stability of DHR123 radio fluorogenic nano clay gel dosimeter by incorporating a new dispersant

Maeyama, Takashige; Yoshida, Kazuki; Watanabe, Yusuke; Inui, Hiroshi

doi:10.1016/j.jphotochem.2021.113423

Cited by 12 publications

(6 citation statements)

References 55 publications

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“…Because surfactants are known to improve both the dose response and light stability, the effect of a dispersant on the Fe 3+ –DHR123 NC‐RFG characteristics when using a carbon‐ion beam was investigated 46 . In these experiments, N ‐vinylpyrrolidone and pyridine were examined as dispersants.…”

Section: Resultsmentioning

confidence: 99%

“…A two-dimensional (2D) fluorescence gel scanner (GELSCAN-3; iMeasure Inc., Japan) was used to evaluate the florescence intensity distribution of each DHR123 gel sample after irradiation. 32,46 This device was a commercially available flatbed color scanner incorporating a moving optical array that allowed scanning with a charge coupled device (CCD). Measurements were performed with excitation at 465 nm and a resolution of 0.25 mm/pixel together with a focal length of 6 mm.…”

Section: Analyzing Dose-response and Two-dimensional Fluorescence Dis...mentioning

confidence: 99%

“…Because surfactants are known to improve both the dose response and light stability, the effect of a dispersant on the Fe 3+ -DHR123 NC-RFG characteristics when using a carbon-ion beam was investigated. 46 In these experiments, N-vinylpyrrolidone and pyridine were examined as dispersants. The sharp peak disappeared in the relative δI FL /ESD distribution after adding N-vinylpyrrolidone to the Fe 3+ -DHR123 NC-RFG (see Figure S9).…”

Section: Effect Of Dispersant On Fe 3+ -Dhr123 Nc-rfgmentioning

confidence: 99%

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Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

et al. 2022

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Purpose The precise assessment of the dose distribution of high linear energy transfer (LET) radiation remains a challenge, because the signal of most dosimeters will be saturated due to the high ionization density. Such measurements are particularly important for heavy‐ion beam cancer therapy. On this basis, the present work examined the high LET effect associated with three‐dimensional gel dosimetry based on radiation‐induced chemical reactions. The purpose of this study was to create an ion beam radio‐fluorogenic gel dosimeter with a reduced effect of LET. Methods Nanoclay radio‐fluorogenic gel (NC‐RFG) dosimeters were prepared, typically containing 100 μM dihydrorhodamine 123 (DHR123) and 2.0 wt% nanoclay together with catalytic additives promoting Fenton or Fenton‐like reactions. The radiological properties of NC‐RFG dosimeters having different compositions in response to a carbon‐ion beam were investigated using a fluorescence gel scanner. Results An NC‐RFG dosimeter capable of generating a fluorescence intensity distribution reflecting the carbon‐ion beam dose profile was obtained. It was clarified that the reduction of the unfavorable LET dependence results from an acceleration of the reactions between DHR123 and H2O2, which is a molecular radiolysis product. The effects of varying the preparation conditions on the radiological properties of these gels were also examined. The optimum H2O2 catalyst was determined to include 1 mM Fe3+ ions, and the addition of 100 mM pyridine was also found to increase the sensitivity. Conclusions This technique allows the first‐ever evaluation of the depth–dose profile of a carbon‐ion beam at typical therapeutic levels of several Gy without LET effect.

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Section: Resultsmentioning

confidence: 99%

Section: Analyzing Dose-response and Two-dimensional Fluorescence Dis...mentioning

confidence: 99%

Section: Effect Of Dispersant On Fe 3+ -Dhr123 Nc-rfgmentioning

confidence: 99%

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Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

et al. 2022

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“…Fluorescence sensors are also used to measure ionizing radiation doses. [17][18][19][20][21] Usually, the underlying mechanism of these sensors involves a weak uorescence moiety combined with hydroxyl radicals due to water radiolysis, transitioning to a strong uorescence moiety. Accordingly, the dosing can be measured by uorescence methodology.…”

Section: Introductionmentioning

confidence: 99%

A rhodamine coumarin-derived fluorescence probe that selectively detects Fe³⁺ and measures radiation doses

Qin,

Han,

Jiang

et al. 2024

Anal. Methods

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“…In recent years, gel dosimeters, which are chemical dosimeters, have been attracting significant attention as promising tools for measuring 3D dose distributions [ 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 ]. Various forms of chemical dosimeters are used, such as the Fricke gel dosimeter [ 22 , 23 , 24 ], which uses the oxidation reaction of iron ions, and the polymer gel dosimeter [ 25 , 26 , 27 ], which uses radiation-induced polymerization in a monomer solution.…”

Section: Introductionmentioning

confidence: 99%

Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method

Mizukami

Watanabe

Mizoguchi

et al. 2021

Gels

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MRI-based gel dosimeters are attractive systems for the evaluation of complex dose distributions in radiotherapy. In particular, the nanocomposite Fricke gel dosimeter is one among a few dosimeters capable of accurately evaluating the dose distribution of heavy ion beams. In contrast, reduction of the scanning time is a challenging issue for the acquisition of three-dimensional volume data. In this study, we investigated a three-dimensional dose distribution measurement method for heavy ion beams using variable flip angle (VFA), which is expected to significantly reduce the MRI scanning time. Our findings clarified that the whole three-dimensional dose distribution could be evaluated within the conventional imaging time (20 min) and quality of one cross-section.

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Improvement of light stability of DHR123 radio fluorogenic nano clay gel dosimeter by incorporating a new dispersant

Cited by 12 publications

References 55 publications

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

A rhodamine coumarin-derived fluorescence probe that selectively detects Fe³⁺ and measures radiation doses

Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method

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Improvement of light stability of DHR123 radio fluorogenic nano clay gel dosimeter by incorporating a new dispersant

Cited by 12 publications

References 55 publications

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

Radio‐fluorogenic nanoclay gel dosimeters with reduced linear energy transfer dependence for carbon‐ion beam radiotherapy

A rhodamine coumarin-derived fluorescence probe that selectively detects Fe3+ and measures radiation doses

Whole Three-Dimensional Dosimetry of Carbon Ion Beams with an MRI-Based Nanocomposite Fricke Gel Dosimeter Using Rapid T1 Mapping Method

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A rhodamine coumarin-derived fluorescence probe that selectively detects Fe³⁺ and measures radiation doses