Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

Inoue, Taketo; Ono, Yukiko; Yonezawa, Yukiko; Kishi, Junji; Emi, Nobuyuki

doi:10.4236/ojog.2014.413103

Cited by 8 publications

(8 citation statements)

References 25 publications

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“…Ovarian stimulation was performed as previously described [ 19 ]. Briefly, long, short, or gonadotropin-releasing hormone (GnRH)-antagonist protocols were used depending on the patient.…”

Section: Methodsmentioning

confidence: 99%

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Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Inoue

Yonezawa²,

Sugimoto³

et al. 2016

Clin Exp Reprod Med

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ObjectiveThe decision to use in vitro fertilization (IVF), intracytoplasmic sperm injection (ICSI), or split insemination (IVF-ICSI) in the first cycle is based on the number of motile sperm. Hence, total fertilization failure (TFF) often occurs during IVF cycles, despite normozoospermia. To investigate whether the cumulative motile swim-up spermatozoa percentage at 22 hours post-insemination (MSPPI) is an indicator for ICSI, we analyzed TFF, fertilization, blastocyst development, chemical pregnancy, clinical pregnancy, and live birth rates.MethodsThis prospective study was performed using data obtained from 260 IVF cycles. At 22 hours after insemination, the remaining swim-up spermatozoa were observed and divided into six groups according to MSPPI (<10%, 10% to <30%, 30% to <50%, 50% to <70%, 70% to <90%, and 90% to 100%).ResultsRegardless of the ejaculated motile sperm concentration (0.6–280×106/mL motile spermatozoa), the incidence of TFF significantly increased when MSPPI was <10%, and the fertilization rate significantly decreased when MSPPI was <30%. We found that cumulative MSPPI correlated with the cumulative fertilization rate (Spearman correlation, 0.508, p<0.001). Regarding embryo development, we observed no significant differences in the rates of blastocyst development, chemical pregnancy, clinical pregnancy, or live birth among all groups.ConclusionOur findings suggest that MSPPI is a viable indicator for split IVF-ICSI and ICSI. Taken together, by employing the MSPPI test in advance before IVF, ICSI, or split IVF-ICSI cycles, unnecessary split IVF-ICSI and ICSI may be avoided.

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“…Ovarian stimulation was performed as previously described [ 19 ]. Briefly, long, short, or gonadotropin-releasing hormone (GnRH)-antagonist protocols were used depending on the patient.…”

Section: Methodsmentioning

confidence: 99%

“…Moreover, patients took a 5 mg prednisolone tablet (Towa Pharmaceutical Co., Osaka, Japan) three times daily for 3 days after ovulation. The dosage of prednisolone was set at 15 mg/day based on a previous study [ 19 ]. Stimulation of the endometrium for embryo transfer [ 25 ] was performed 2 or 3 days before FBT.…”

Section: Methodsmentioning

confidence: 99%

Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Inoue

Yonezawa²,

Sugimoto³

et al. 2016

Clin Exp Reprod Med

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“…To verify that this higher intra-cohort (i.e., between siblings) similarity is not an artifact due to the random selection of embryos, we compared intraversus inter-cohort similarity in the morphokinetic profiles of embryos with similar morphological qualities. We considered the manually annotated Gardner and Schoolcraft alphanumeric quality scoring scheme as a proxy for embryo morphological-based quality, which is based on the assessment of three parameters: blastocyst expansion status, morphology of the inner cell mass (ICM), and morphology of the trophectoderm (TE) [31,32] (Fig. 1H).…”

Section: Embryos From the Same Cohort Are Phenotypically Correlatedmentioning

confidence: 99%

Using unlabeled information of embryo siblings from the same cohort cycle to enhance in vitro fertilization implantation prediction

Tzukerman

Rotem

Shapiro³

et al. 2022

Preprint

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High content time-lapse embryo imaging assessed by machine learning is revolutionizing the field of in vitro fertilization (IVF). However, the vast majority of IVF embryos are not transferred to the uterus, and these masses of embryos with unknown implantation outcomes are ignored in current efforts that aim to predict implantation. Here, we explore whether, and to what extent the information encoded within “sibling” embryos from the same IVF cohort contribute to the performance of machine learning-based implantation prediction. First, we show that the implantation outcome is correlated with attributes derived from the cohort siblings. Second, we demonstrate that this unlabeled data boosts implantation prediction performance. Third, we characterize the cohort properties driving embryo prediction, especially those that rescued erroneous predictions. Our results suggest that predictive models for embryo implantation can benefit from the overlooked, widely available unlabeled data of sibling embryos by reducing inherent noise of the individual transferred embryo.Significance statementWe use in vitro fertilization (IVF) as a model to study the effect of genotypic and environmental variation on phenotype and demonstrate a potential translational application. This is achieved by associating the implantation potential of transferred embryos and the visual information encoded within their non-transferred “sibling” embryos from the same IVF cohort, and establishing that these cohort features contribute to consistent improvement in machine learning implantation prediction regardless of the embryo-focused model. Our results suggest a general concept where the uncertainty in the implantation potential for the transferred embryo can be reduced by information encapsulated in the correlated cohort embryos. Since the siblings’ data are routinely collected, incorporating cohort features in AI-driven embryo implantation prediction can have direct translational implications.

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“…After a year, Gizzo as a defender of aspirin administration takes success less of such researches into account as lack of suitable protocol (41); but even in his research, numbers of good-quality embryos were decreased in group of low dose aspirin administration. Another research (42) announced that inhibition of NKs -with aspirin or prednisolone -results…”

Section: Role Of Inflammation In Implantationmentioning

confidence: 99%

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

Ahmadi¹,

Shahsavar²,

Akbari³

2016

IJWHR

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IntroductionAmong the controversies in reproduction science, role of immune and inflammatory systems in implantation process and durability of pregnancy is a hot topic nowadays. Some researchers and practitioners believe that administration of drugs such as prednisolone, aspirin or heparin can improve success rate of implantation and pregnancy through inhibiting coagulation, inflammatory and immune systems; while others believe that such systems not only do not have negative effect on rejecting blastocyst and embryo by itself but also are necessary for implantation and remodeling of uterine spiral arteries through secreting adhesive and angiogenic factors. Such controversies are proposed both in natural pregnancies resulting in spontaneous abortion as well as in successful and/or unsuccessful assisted reproductive technologies (ARTs). Recurrent spontaneous abortion (RSA) is defined as having 3 or more history of abortion (1). About the other issue, some researchers and practitioners are grumbling of low success rate of ARTs like in vitro fertilization (IVF). Infertility is a problem for 10%-15% of couples; most of which -but not all -require ART (2). The average fertilization rate of ART in previous researches has been reported about 30% (3) and this report is for 1998. It has been claimed in an article published in 2015 that this rate has improved in the recent decade (4). Even though at the first glance this rate seems low, but the interesting point is that in the claim of a valid reference (5) the chance of natural pregnancy for each intercourse per month does not go up more than 33%. Also this number has been reported in some studies up to 40% (6). Thus, we should not be grumbling of the low fertilization rate of ARTs. Finally we intend to represent and report our insights, reasoning and suggestions in the present review. MethodsThis systematic and critical review includes investigation of scientific data bases and tracing the citations and the references of the articles in order to find the root of the truth. Through this wisdom, we showed the mere that a content proposed in an indexed article is not a reason that this content is valid and able to be cited. Indeed, the researcher should regard and notice the reasoning, citations and protocol of his/her references during the literature review. This is the benefit point of systematic review rather than holistic and narrative reviews. Since some data were few, the time period of publications was not important to us. As the searching strategy, we used the Web of Science Core Collection and Google Scholar for finding articles other than ISI-WOS and the tracing mentioned in the above paragraph. Results and DiscussionRole of Immune System and Leukocytes In 2015, Ghafourian et al (1) by measuring the level of natural killer-cells (NKs) in blood of the RSA and the control group concluded that RSA patients in normal (non-preg- AbstractAmong the controversies about reproduction sciences, role of immune and inflammatory systems in implantation process and durability of...

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Improvement of Live Birth Rate Following Frozen-Thawed Blastocyst Transfer by Combination of Prednisolone Administration and Stimulation of Endometrium Embryo Transfer

Cited by 8 publications

References 25 publications

Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Percentage of motile spermatozoa at 22 hours after swim-up procedure: An indicator for intracytoplasmic sperm injection?

Using unlabeled information of embryo siblings from the same cohort cycle to enhance in vitro fertilization implantation prediction

A Review on Controversies about the Role of Immune and Inflammatory Systems in Implantation Process and Durability of Pregnancy

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