Improvement of mechanical properties and biocompatibility of forsterite bioceramic addressed to bone tissue engineering materials

A comparative study of proliferation and osteogenic differentiation of rat adipose-derived stem cells in β-tricalcium phosphate (β-TCP), forsterite (Mg2SiO4) and clinoenstatite (MgSiO3)

“…The optimal concentration to promote proliferation of rat ASCs were 12.5 mg/mL for MS, 6.25 mg/mL for M 2 S and β-TCP respectively on day 4 post seeding ( Figure 2). The results are consistent with that from Kharaziha et al's study [31], in which G292 cells were used.…”

Novel fabrication of forsterite scaffold with improved mechanical properties

“…Forsterite (Mg 2 SiO 4 ) is an important material of olivine family of crystals in the magnesia-silica system. Recently researches have shown that it is a biocompatible material, possess excellent in vitro apatite-formation ability, in vivo bioactivity and degradability [23][24][25][26][27][28][29], improved mechanical properties compared to hydroxyapatite [28], and can be useful as a biomaterial * Corresponding author. [23,30,31].…”

Biocompatibility of differently proportioned HA/PLGA/BMP-2 composite biomaterials in rabbits

“…In the meantime, the concomitant fibroblast proliferation and newborn tissues promoted bone repair and reconstruction. These materials are therefore applicable to bone tissue engineering owing to their high biocompatibility (Bhattarai et al, 2008;Kharaziha and Fathi, 2010;Lin et al, 2012), a characteristic feature of analogous materials. Of the three materials assessed in this study (Ji et al, 2010;Lee et al, 2011), HA [Ca 10 (PO 4 ) 6 (OH) 2 ] is widely distributed in human tooth enamel (present at over 96%) and is highly biocompatible with the human body.…”