Improvement of Oxidative and Metabolic Parameters by Cellfood Administration in Patients Affected by Neurodegenerative Diseases on Chelation Treatment

Abstract

Objective. This prospective pilot study aimed at evaluating the effects of therapy with antioxidant compounds (Cellfood, and other antioxidants) on patients affected by neurodegenerative diseases (ND), who displayed toxic metal burden and were subjected to chelation treatment with the chelating agent calcium disodium ethylenediaminetetraacetic acid (CaNa2EDTA or EDTA). Methods. Two groups of subjects were studied: (a) 39 patients affected by ND and (b) 11 subjects unaffected by ND (controls). The following blood parameters were analyzed before and after three months' treatment with chelation + Cellfood or chelation + other antioxidants: oxidative status (reactive oxygen species, ROS; total antioxidant capacity, TAC; oxidized LDL, oxLDL; glutathione), homocysteine, vitamin B12, and folate. Results. After 3-months' chelation + Cellfood administration oxLDL decreased, ROS levels were significantly lower, and TAC and glutathione levels were significantly higher than after chelation + other antioxidants treatment, both in ND patients and in controls. Moreover, homocysteine metabolism had also improved in both groups. Conclusions. Chelation + Cellfood treatment was more efficient than chelation + other antioxidants improving oxidative status and homocysteine metabolism significantly in ND patients and controls. Although limited to a small number of cases, this study showed how helpful antioxidant treatment with Cellfood was in improving the subjects' metabolic conditions.

Rationale for the Successful Management of EDTA Chelation Therapy in Human Burden by Toxic Metals

“…Toxic metals also exert an important role in the pathogenesis of ND. EDTA chelation therapy has been shown to improve neurologic symptoms in ND patients [48, 68], and results are further enhanced by the use of antioxidants. EDTA chelation therapy, at the dose of 2 g/week slowly injected IV in adults, does not provoke side effects, can be used for a long period to ameliorate both acute and chronic intoxications, and is able to remove all toxic metals and reduce oxidative stress injury and inflammation in blood vessel walls [50, 51, 60, 65, 73, 90].…”

“…EDTA chelation therapy, whose usefulness has been shown in the elimination of Al intoxication [48], can therefore be recommended for the removal of other toxic metals responsible for ND development. The beneficial effect of EDTA treatment has been demonstrated by the neurological relief of symptoms such as spasticity, fatigue, and relapse in patients intoxicated by Al and affected by ND [48, 58, 68]. EDTA has been shown to be useful in attenuating peripheral blood cell damage in workers exposed to Pb [69].…”

“…The antioxidant treatments could be glutathione (Ultrathione, 500 mg/day), alone or together with multivitamin complexes, amino acid and mineral mixtures, or probiotics. We have already shown how chelation therapy with CaNa 2 EDTA, associated with the antioxidant compound Cellfood, can significantly improve the blood parameters of patients affected by ND, as well as those of unaffected healthy patients (controls) [68]. Indeed, after three-month chelation+Cellfood administration, oxidized LDL (oxLDL) decreased, ROS levels were significantly lower, and total antioxidant capacity (TAC) and glutathione levels were significantly higher than following chelation+other above reported antioxidant treatments.…”

Oxidative status in treatment-naïve essential thrombocythemia: a pilot study in a single center

“…The selection aimed to avoid any confounding factor and to assess if OS could really play a role in the pathogenesis of this disorder. To date, the evaluation of OS remains difficult, and the use of oxidants, together with antioxidant parameters, which better reflect the redox balance, is generally considered more complete and powerful to assess the oxidative status .…”

“…GSSG concentration was calculated by subtracting the GSH amount from the total glutathione. GSH/GSSG ratio was also evaluated .…”