Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery

Salman, Ahmed; Salman, Mohamed Abdalla; Said, Mostafa; Sherbiny, Mohammad El; Elkassar, Hesham; Hassan, Mohamed Badr; Marwan, Ahmed I.; Morad, Mohamed Abdelkader; Ashoush, Omar; Labib, Safa; Aon, Mohamed; Awad, Abeer; Sayed, Mohamed; Taha, Ahmed E.; Moustafa, Ahmed A.; Shaaban, Hossam El‐Din; Khater, Amir; Elewa, Ahmed; Khalaf, A. M.; Mostafa, Ahmed; Matter, Mohamed; Youssef, Ahmed M.

doi:10.3389/fmed.2022.894465

Cited by 13 publications

(3 citation statements)

References 56 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…It has also demonstrated that bariatric surgery can lead to significant reductions in fat accumulation within the pancreas. 124 Nonetheless, education regarding healthy dietary habits and regular exercise should be the mainstay for reducing the NAFPD risk, as well as for treating those already diagnosed with it.…”

Section: Treatment Of Nafpdmentioning

confidence: 99%

Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease

Pagkali,

Makris,

Brofidi

et al. 2024

DMSO

View full text Add to dashboard Cite

Non-Alcoholic Fatty Pancreas disease (NAFPD), characterized by fat accumulation in pancreatic tissue, is an emerging clinical entity. However, the clinical associations, the underlying molecular drivers, and the pathophysiological mechanisms of NAFPD have not yet been characterized in detail. The NAFPD spectrum not only includes infiltration and accumulation of fat within and between pancreatic cells but also involves several inflammatory processes, dysregulation of physiological metabolic pathways, and hormonal defects. A deeper understanding of the underlying molecular mechanisms is key to correlate NAFPD with clinical entities including non-alcoholic fatty liver disease, metabolic syndrome, diabetes mellitus, atherosclerosis, as well as pancreatic cancer and pancreatitis. The aim of this review is to examine the pathophysiological mechanisms of NAFPD and to assess the possible causative/ predictive risk factors of NAFPD-related clinical syndromes.

show abstract

Section: Treatment Of Nafpdmentioning

confidence: 99%

Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease

Pagkali,

Makris,

Brofidi

et al. 2024

DMSO

View full text Add to dashboard Cite

show abstract

“…Bariatric surgery has a proven effect on type 2 diabetes improvement ( 1 ). Several studies have shown a reduction in pancreatic fat accumulation following bariatric surgery, an effect that might improve glucose homeostasis ( 13 , 59 , 60 ). Accordingly, an amelioration of pancreas steatosis together with a downregulation of the lipogenic genes Srebf1, Mogat2 and Dgat1 was observed following sleeve gastrectomy.…”

Section: Discussionmentioning

confidence: 99%

Effect of guanylin peptides on pancreas steatosis and function in experimental diet-induced obesity and after bariatric surgery

et al. 2023

View full text Add to dashboard Cite

IntroductionObesity contributes to ectopic fat deposition in non-adipose organs, including the pancreas. Pancreas steatosis associates with inflammation and β-cell dysfunction, contributing to the onset of insulin resistance and type 2 diabetes. An improvement of pancreatic steatosis and indices of insulin resistance is observed following bariatric surgery, but the underlying mechanisms remain unknown. We sought to analyze whether guanylin (GUCA2A) and uroguanylin (GUCA2B), two gut hormones involved in the regulation of satiety, food preference and adiposity, are involved in the amelioration of pancreas fat accumulation after bariatric surgery.MethodsPancreas steatosis, inflammation, islet number and area were measured in male Wistar rats with diet-induced obesity (n=125) subjected to surgical (sham operation and sleeve gastrectomy) or dietary (pair-fed to the amount of food eaten by gastrectomized animals) interventions. The tissue distribution of guanylate cyclase C (GUCY2C) and the expression of the guanylin system were evaluated in rat pancreata by real-time PCR, Western-blot and immunohistochemistry. The effect of guanylin and uroguanylin on factors involved in insulin secretion and lipogenesis was determined in vitro in RIN-m5F β-cells exposed to lipotoxic conditions.ResultsSleeve gastrectomy reduced pancreas steatosis and inflammation and improved insulin sensitivity and synthesis. An upregulation of GUCA2A and GUCY2C, but not GUCA2B, was observed in pancreata from rats with diet-induced obesity one month after sleeve gastrectomy. Interestingly, both guanylin and uroguanylin diminished the lipotoxicity in palmitate-treated RIN-m5F β-cells, evidenced by lower steatosis and downregulated lipogenic factors Srebf1, Mogat2 and Dgat1. Both guanylin peptides reduced insulin synthesis (Ins1 and Ins2) and release from RIN-m5F β-cells, but only guanylin upregulated Wnt4, a factor that controls β-cell proliferation and function.DiscussionTogether, sleeve gastrectomy reduced pancreatic steatosis and improved β-cell function. Several mechanisms, including the modulation of inflammation and lipogenesis as well as the upregulation of GUCA2A in the pancreas, might explain this beneficial effect of bariatric surgery.

show abstract

“…Salman (n = 54) после выполнения продольной резекции желудка доля жировой ткани в ПЖ уменьшилась с 26,8 ± 7,2 % до 20,0 ± 7,3 %, а также определялось существенное снижение активности панкреатической липазы плазмы (р < 0,001). Кроме того, была замечена положительная корреляция между процентом общей потери массы тела и уменьшением доли жира в ПЖ (r = 0,295, р = 0,030) [34].…”

Section: рисунокunclassified

Metabolic aspects of fatty pancreatic disease

Mozgunova,

Semikova,

Khalimov

et al. 2024

View full text Add to dashboard Cite

Aim. To update the understanding of non-alcoholic fatty pancreatic disease as an important component of the development and maintenance of metabolic syndrome, to present current data on the connection of this pathology with cardiovascular risks, and to outline approaches to diagnosis and treatment. Key points. Metabolic syndrome is one of the most common pathologies that significantly increases cardiovascular risks. It is known that excessive accumulation of lipids in the pancreas in patients with metabolic syndrome inevitably entails impaired functioning of beta cells. However, the term characterizing metabolic dysfunction of the pancreas against the background of its steatosis was introduced into circulation relatively recently. Thus, non-alcoholic fatty pancreatic disease acquires its own definitions that distinguish it from the traditional morphological approach, which consists more in assessing the content of the proportion of adipose tissue, but not the connection with the components of the metabolic syndrome. It is known that patients with non-alcoholic fatty pancreatic disease are more likely to have type 2 diabetes mellitus, arterial hypertension and atherosclerosis. Probably, the pathogenesis of its development is also closely related to non-alcoholic fatty liver disease. Conclusion. Non-alcoholic fatty pancreatic disease, being one of the key mechanisms of metabolic dysfunction, requires further research in order to determine preventive and therapeutic tactics. Keywords: insulin resistance, non-alcoholic fatty pancreatic disease, pancreatic steatosis, metabolic syndrome.

show abstract

Improvement of Pancreatic Steatosis and Indices of Insulin Resistance After Metabolic Surgery

Cited by 13 publications

References 56 publications

Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease

Pathophysiological Mechanisms and Clinical Associations of Non-Alcoholic Fatty Pancreas Disease

Effect of guanylin peptides on pancreas steatosis and function in experimental diet-induced obesity and after bariatric surgery

Metabolic aspects of fatty pancreatic disease

Contact Info

Product

Resources

About