Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts

Lipovac, Markus; Chedraui, Peter; Gruenhut, Christine; Gocan, Ana; Stammler, Maria; Imhof, Martin

doi:10.1016/j.maturitas.2009.10.014

Cited by 70 publications

(103 citation statements)

References 48 publications

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“…Studies on the effects of isoflavones on bone metabolism provided controversial results, but simultaneously, the effectiveness of phytoestrogenic therapy on other menopause-related disorders has been confirmed by Lipovac et al (2010). This randomised clinical investigation was designed to evaluate the effects of a non-prescription red clover extract (MF11RCE) on mood disorders.…”

Section: Trifolium Plants In the Therapy Of Menopause-related Disordersmentioning

confidence: 99%

Trifolium species-derived substances and extracts—Biological activity and prospects for medicinal applications

Kołodziejczyk-Czepas

2012

Journal of Ethnopharmacology

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Section: Trifolium Plants In the Therapy Of Menopause-related Disordersmentioning

confidence: 99%

Trifolium species-derived substances and extracts—Biological activity and prospects for medicinal applications

Kołodziejczyk-Czepas

2012

Journal of Ethnopharmacology

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“…A meta-analysis performed by Thompson Coon et al (2007) provided some evidence of marginally significant effect of T. pratense isoflavones for treating hot flushes in menopausal women. Contrary to this critical conclusion, a growing number of reports suggest the considerable medicinal value of red clover, e.g., the improvement of postmenopausal depressive and anxiety symptoms (Lipovac et al, 2010). Moreover, other beneficial activities of substances and extracts of T. pratense, such as cardiovascular disease-preventive effects, were also (Asgary et al, 2007).…”

Section: Introductionmentioning

confidence: 99%

Free radical scavenging actions of threeTrifoliumspecies in the protection of blood plasma antioxidant capacityin vitro

Kołodziejczyk-Czepas

Nowak

Moniuszko-Szajwaj

et al. 2015

Pharmaceutical Biology

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Context: Three clover [Trifolium L. (Leguminosae)] species were selected on the basis of data from traditional medicine, phytochemical profiles, and agricultural significance. Objective: The in vitro evaluations of free radical scavenging properties, ferric reducing abilities, and antioxidant effects of extracts from T. pratense L. (crude extract and phenolic fraction), T. pallidum L., and T. scabrum L. (phenolic fractions) were performed. Materials and methods: Activities of the Trifolium extracts were determined at their final concentrations of 1.5-50 mg/ml. Free radical scavenging properties of methanol extract solutions were estimated by the reduction of DPPH and ABTS radicals. Measurements of the total antioxidant capacity (TAC) were carried out to assess the antioxidant activities of the extracts in human blood plasma under conditions of oxidative stress, induced by 200 mM peroxynitrite. Results: The phenolic fraction of T. pratense displayed the strongest ABTS and DPPH radical scavenging effects (EC 50 value of 21.69 and 12.27 mg/ml, respectively). The EC 50 value for T. pallidum extract attained 29.77 and 30.06 mg/ml. The two remaining extracts were less potent scavengers (EC 50 value higher than 50 mg/ml). Similar differences were obtained during evaluation of the ferric reducing abilities. Analysis of antioxidant properties of the extracts in blood plasma did not provide such evident differences in their actions, however, it indicated that the T. pratense phenolic fraction displayed the strongest effect. Conclusions: The examined Trifolium extracts partly protected blood plasma and enhanced its non-enzymatic antioxidant defense against harmful action of peroxynitrite in vitro.

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“…Istnieją dowody na skuteczność preparatu Promensil ® w redukcji nasilenia objawów pozasomatycznych menopauzy [18]. Po 6 miesiącach stosowania tego produktu stwierdzono znamienną poprawę w zakresie nastroju depresyjnego i występowania nerwowości lub niepokoju u kobiet pomenopauzalnych.…”

Section: Promensilunclassified

Stanowisko Zespołu Ekspertów Polskiego Towarzystwa Menopauzy i Andropauzy dotyczące zastosowania preparatów PROMENSIL® i PROMENSIL FORTE® u kobiet w okresie około- i pomenopauzalnym

Dębski¹,

Paszkowski²,

Pertyński³

et al. 2013

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Improvement of postmenopausal depressive and anxiety symptoms after treatment with isoflavones derived from red clover extracts

Cited by 70 publications

References 48 publications

Trifolium species-derived substances and extracts—Biological activity and prospects for medicinal applications

Trifolium species-derived substances and extracts—Biological activity and prospects for medicinal applications

Free radical scavenging actions of threeTrifoliumspecies in the protection of blood plasma antioxidant capacityin vitro

Stanowisko Zespołu Ekspertów Polskiego Towarzystwa Menopauzy i Andropauzy dotyczące zastosowania preparatów PROMENSIL® i PROMENSIL FORTE® u kobiet w okresie około- i pomenopauzalnym

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