Improvement of Postprandial Lipid Metabolism After Ileal Transposition in Non-obese Diabetic Rats

Chen, Weijie; Yin, Haixin; Zhang, Ning; Liu, Wei; Qu, Qiang; Xiao, Jianchun; Gong, Fengying; He, Xiaoli

doi:10.1007/s11695-020-05158-z

Cited by 4 publications

(5 citation statements)

References 30 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IT procedures, as a bariatric surgery, could effectively improve glucose metabolism, which is in agreement with previous findings 10 , 25 . The level of FPG and AUC OGTT in the IT group decreased significantly after surgery and was lower than those in the SH group at postoperative week 20.…”

Section: Discussionsupporting

confidence: 93%

“…Surgery would disrupt BA reabsorption in the ileum and gut microbial communities which lead to BA changes [9]. We verified that IT surgery procedures could accelerate the enterohepatic circulation rate of BAs and elevate plasma total BA levels [10]. However, the detailed BA profiles after IT is undefined.…”

Section: Ivyspringmentioning

confidence: 59%

“…The level of FPG and AUC OGTT in the IT group decreased significantly after surgery and was lower than those in the SH group at postoperative week 20. We previously proposed a role of BAs in the improvement of glucose metabolism but did not analyze BA profiles changes or investigate the downstream mechanism 10 . In this study, 17 kinds of BAs were measured and compared, and the level of β-MCA, T-α-MCA and T-β-MCA in plasma in the IT group was higher than those in the SH group.…”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Chen¹,

Zhou²,

Xiao³

et al. 2023

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

Background: Aim to investigate bile acid profile changes and the Farnesoid X receptor (FXR) status after ileotransposition (IT), and reveal its possible hypoglycemic mechanism. Methods: Twenty male diabetic rats were randomly assigned into the IT group and the sham IT (SH) group. Bile acid profiles were measured using an ultra-performance liquid chromatography-tandem mass spectrometry. Glucose metabolism was monitored after oral administration of FXR inhibitor and agonist. And the expression of key FXR target genes were measured. Results:The levels of β-muricholic acid (P = 0.047), tauro-α-muricholic acid and tauro-β-muricholic acid (P < 0.001) in plasma in the IT group were higher than those in the SH group, and the levels of taurocholic acid (P = 0.049) and turoursodeoxycholic acid (P = 0.030) were lower than those in the SH group. After inhibition of intestinal FXR, the glucose metabolism in the SH group was improved. When FXR agonist was given, the blood glucose level was increased in both groups. After sacrifice, the levels of glycoursodeoxycholic acid, tauro-α-muricholic acid and tauro-β-muricholic acid in liver and ileum tissues were higher than those in the SH group (P < 0.05), the level of αmuricholic acid (P < 0.001) in liver tissues were lower than that in the SH group. Moreover, the expression of CYP7A1 mRNA (P < 0.001) and FGF15 mRNA (P = 0.001) in the IT group was significantly higher, and the expression of PEPCK mRNA (P = 0.004), SREPB1c mRNA (P = 0.005) and SRB1 mRNA (P = 0.001) were significantly lower than that in the SH group. Conclusions: We demonstrate a remarkable heterogeneity of BA profiles after IT, FXR activation might has a detrimental effect on glucose metabolism.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Ivyspringmentioning

confidence: 59%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Chen¹,

Zhou²,

Xiao³

et al. 2023

Int. J. Med. Sci.

Self Cite

View full text Add to dashboard Cite

show abstract

“…The main detection indexes of glucose and lipid metabolism include fasting insulin (FINS), insulin resistance index (HOMA-IR), fasting blood glucose (FPG), 2h postprandish blood glucose (2hPG), glycated hemoglobin (HbA1c), C-peptide, etc. [21][22] Lipid metabolism: Total cholesterol (TC), triglyceride (TG), serum low density lipoprotein cholesterol (LDL-C), high density lipoprotein cholesterol (HDL-C) [23][24].…”

Section: Glycolipid Metabolismmentioning

confidence: 99%

Correlation between TCM syndrome type distribution and glycolipid metabolism in obese type 2 diabetes mellitu

2023

medcm

View full text Add to dashboard Cite

This paper mainly discusses the distribution characteristics of TCM Syndrome Types in obese 2 diabetes patients and the correlation between TCM Syndrome Types and glucose metabolism and lipid metabolism. Through consulting, screening, analyzing and summarizing the relevant literature, the correlation between TCM Syndrome Types and glucose metabolism, lipid metabolism in obese patients with type 2 diabetes was summarized and studied. It can provide reference and new thinking direction for TCM clinical treatment of obesity 2 diabetes.

show abstract

“…Neuere Studien an diätinduzierten adipösen Ratten konnten nachweisen, dass es durch die IT zu einer verbesserten Glukosetoleranz mit verbesserter postprandialer Insulinausschüttung bei erhöhter β-Zellmasse und reduzierter β-Zellalterung kommt, worin die Autoren einen therapeutischen Ansatz für die Behandlung von Typ-2-Diabetes sahen 36 . Zudem konnte eine signifikante Verbesserung des Lipidstoffwechsels durch die IT nachgewiesen werden 37 . 2006 wurden für die Anwendung beim Menschen die ersten Daten publiziert.…”

Section: Ileale Transpositionunclassified

Der Stellenwert neuerer Verfahren in der Adipositaschirurgie (SADI, SASI und Co.)

Gärtner¹,

Schöttler²,

Popp³

2022

Allgemein- und Viszeralchirurgie up2date

View full text Add to dashboard Cite

Die Adipositaschirurgie bietet die effektivste Therapieoption für die Adipositas und ihre Nebenerkrankungen. Von Beginn an unterlag diese Chirurgie einem steten Wandel. Durch Modifikationen etablierter OP-Methoden wollen die neueren Verfahren die Invasivität und die unerwünschten Wirkungen reduzieren. Der folgende Beitrag zeigt, inwieweit dies gelingt und welche Verfahren das Potenzial zum Standardverfahren haben.

show abstract

Improvement of Postprandial Lipid Metabolism After Ileal Transposition in Non-obese Diabetic Rats

Cited by 4 publications

References 30 publications

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Farnesoid X receptor is inhibited after ileum transposition in diabetic rats: its hypoglycemic effect

Correlation between TCM syndrome type distribution and glycolipid metabolism in obese type 2 diabetes mellitu

Der Stellenwert neuerer Verfahren in der Adipositaschirurgie (SADI, SASI und Co.)

Contact Info

Product

Resources

About