Improvement of Pressure Flow Parameters With Finasteride Is Greater in Men With Large Prostates

Abrams, Paul; Schäfer, Werner; Tammela, Teuvo L.J.; Barrett, David M.; Hedlund, Hans; Rollema, Harm J.; Matos-Ferreira, A.; Nordling, Jørgen; Bruskewitz, Reginald C.; Andersen, Jens T.; Hald, T; Miller, Paul D.; Kirby, Roger; Mustonen, S.; Cannon, Andréa; Jacobsen, Carol A.; Gormley, Glenn J.; Malice, Marie‐Pierre; Bach, Michael K.

doi:10.1097/00005392-199905000-00026

Cited by 7 publications

(7 citation statements)

References 10 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Many RCTs have demonstrated the clinical efficacy of finasteride in reducing prostate volume and in improving symptom scores and urinary flow rates [46, 49, 86, 87, 88, 89, 90, 91, 92, 93, 94, 95, 96, 97, 98, 99, 100](table 4, 5, 6). Two pivotal phase III trials demonstrated clinical benefit in patients treated with finasteride 5 mg over placebo [91, 94].…”

Section: Resultsmentioning

confidence: 99%

“…Upon analysis, it was discovered that the difference in the magnitude of improvement between finasteride and placebo becomes significant for men with baseline prostate volumes of >40 cm 3 , and that baseline prostate volume was the key predictor of treatment outcomes, with approximately 80% of the variation in the treatment effects noted between studies attributable to differences in mean baseline prostate volume. Furthermore, men with prostates of >40 cm 3 also showed greater improvement in terms of prostate volume and urinary flow in another recent multi–centre international trial of 200 symptomatic men [99]. In the major trial reporting minimal impact of finasteride on QOL and symptom scores described above, the mean prostate volume was only 36 cm 3 [46], and thus these patients do not represent those most expected to benefit from finasteride therapy.…”

Section: Resultsmentioning

confidence: 99%

See 1 more Smart Citation

Medical Therapy for Benign Prostatic Hyperplasia: A Review of the Literature

Clifford¹,

Farmer²

2000

European Urology

137

View full text Add to dashboard Cite

Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

Medical Therapy for Benign Prostatic Hyperplasia: A Review of the Literature

Clifford¹,

Farmer²

2000

European Urology

137

View full text Add to dashboard Cite

“…According to the AUA symptom score, this patient has mild symptoms of BPH (mild, 0-7; moderate, [8][9][10][11][12][13][14][15][16][17][18][19]; and severe, 20-35). 10 The AUA symptom index is a reliable and valid method to assist with both diagnosing BPH and monitoring patients' symptoms over time (see Table).…”

Section: Discussionmentioning

confidence: 99%

Clinical Pearls in Men's Health

Beckman

Litin

2010

Mayo Clinic Proceedings

View full text Add to dashboard Cite

“…Mediante estudio de presión/flujo, Abrams et al 27 observaron que Finasterida provocaba una disminución significa-…”

Section: Tabla IV (Continuación) Caracterización De Los Estudios Reviunclassified

Finasterida: diez años de uso clínico. Revisión sistemática de la literatura

Cruz

Gutiérrez²,

Señarís³

2003

Actas Urol Esp

View full text Add to dashboard Cite

RESUMEN"FINASTERIDA: DIEZ AÑOS DE USO CLÍNICO. REVISIÓN SISTEMÁTICA DE LA LITERATURA" INTRODUCCIÓN: Después de diez años de uso clínico de Finasterida en el tratamiento farmacológico de la Hiperplasia Benigna de Próstata (HBP), nos planteamos revisar la literatura, para analizar aquellos trabajos que por diseño y calidad metodológica, nos permita aplicar recomendaciones basadas en evidencias clínicas.MATERIAL Y MÉTODOS: Utilizando las bases de datos informáticas disponibles en Medline, Embase, Healthstar, y la Cochrane Library (1990Library ( -2002, se recogieron todos los trabajos referentes a pacientes entre 50 y 85 años, con síntomas del tramo urinario inferior sugerentes de HBP y con parámetros objetivos, como flujometría, medición del volumen prostático y del residuo post-miccional, presión del detrusor, efectos adversos, costeefectividad, calidad de vida.RESULTADOS: Se encontraron un total de 137 referencias, de las cuales 36 cumplen los criterios de inclusión, que permiten su clasificación por niveles de evidencia. Tres tienen nivel I, 12 nivel II, 6 nivel III y 10 nivel IV. Tres son estudios económicos y dos evalúan calidad de vida.COMENTARIOS: Con alto nivel de evidencia y después de diez años de uso, se demuestra que Finasterida es efectivo en reducir la sintomatología en los pacientes con próstatas mayores de 40 ml y/o PSA >1,4 ngr/ml, con escasos efectos adversos y una clara mejoría en la calidad de vida, por lo que es recomendable con grado A, su uso clínico.CONCLUSIONES: Finasterida, al reducir el volumen prostático (nivel de evidencia I), modifica la evolución natural de la HBP, disminuyendo el riesgo de retención aguda de orina y de cirugía.PALABRAS CLAVE: Hiperplasia Benigna de Próstata. Finasterida. Medicina basada en la Evidencia. Calidad de Vida. ABSTRACT "FINASTERIDE: TEN YEARS OF CLINICAL USE. SISTEMATIC REVISION OF BIBLIOGHRAPHY" INTRODUCTION:After ten years of clinical use of Finasteride in patientes with BPH, we carried out a systematic review of the literature including the assessment of their quality and grading the level of evidence for clinical recommendations.METHODS: Using Medline, Embase, Healthstar and Cochrane Library from 1990 until 2002, we select all the studies refering patients between 50 to 85 with symptoms of BPH, metrics of flow, prostatic volume, postmictional residue, detrusor pressure, adverse effects, cost-efecctiveness and quality of life.RESULTS: We found out 135 references, of which 36 accomplish the inclusion criteria. Of those, 3 have got level I of evidence, 12 level II, 6 level III and 10 level IV. Three are economic studies and two evaluate the quality of life. DISCUSSION: With a high level of evidence and after ten years of clinical use, Finasteride shows its effectiveness in reducing the symptoms of patients with prostate bigger than 40 ml and/or PSA of more than 1.4 ngr/ml, with scarce adverse effects with a clear improvement of quality of life. Therefore, it is recommended (grade A) for clinical use.CONCLUSIONS: Finasteride, through prostate volume reducti...

show abstract

Improvement of Pressure Flow Parameters With Finasteride Is Greater in Men With Large Prostates

Abstract: Finasteride treatment resulted in improvements in urodynamic parameters, which were greater in men with large prostates.

Cited by 7 publications

References 10 publications

Medical Therapy for Benign Prostatic Hyperplasia: A Review of the Literature

Medical Therapy for Benign Prostatic Hyperplasia: A Review of the Literature

Clinical Pearls in Men's Health

Finasterida: diez años de uso clínico. Revisión sistemática de la literatura

Contact Info

Product

Resources

About