Improvement of psoriatic onychodystrophy by a water‐soluble nail lacquer

Cantoresi, Franca; Sorgi, Paola; Arcese, Annalisa; Bidoli, Antonella; Bruni, Francesca; Carnevale, Claudia; Calvieri, Stefano

doi:10.1111/j.1468-3083.2009.03209.x

Cited by 23 publications

(13 citation statements)

References 5 publications

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“…As a consequence, a number of pharmaceutical nail lacquers, such as Penlac ® (containing ciclopirox), Loceryl ® (containing amorolfine), Onytec ® (containing ciclopirox), Kerydin™ (containing tavaborole), Jublia ® (containing efinaconazole) are commercially available for the topical treatment of onychomycosis. Much research into the formulation of pharmaceutical nail varnish is also ongoing, for example, thermogelling lacquers [7], bilayered lacquers [8], phase-separating lacquers [9], and those containing hydrosoluble polymers [10], econazole [11], terbinafine [12], clotrimazole [13], clobetasol [14], natural products [15,16] and urea [17], among others.…”

Section: Introductionmentioning

confidence: 99%

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

Murdan¹,

Kerai²,

Hossin³

2015

Journal of Drug Delivery Science and Technology

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In vitro-in vivo correlations AdhesionIn vivo residence a b s t r a c t Pharmaceutical nail lacquers are used to topically treat nail fungal infections. The film's residence on the nail is an important factor, and in the laboratory, rapid in vitro adhesion and water resistance tests are often used to indicate their likely in vivo residence. However, the predictivity of such in vitro tests is unknown. The aim of this work was thus to determine whether, and to what extent, such in vitro tests can correctly predict the in vivo fate of nail lacquers. The in vivo residence of four commercially available nail lacquers (three pharmaceutical and one cosmetic) was determined in 16 volunteers. In vitro, the films' resistance to water, and their adhesion to a model nail plate was measured, and in vitro-in vivo correlations were explored. It was found that the in vitro films' resistance to water correctly predicted the in vivo residence of lacquers, while the adhesion tests did not.

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Section: Introductionmentioning

confidence: 99%

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

Murdan¹,

Kerai²,

Hossin³

2015

Journal of Drug Delivery Science and Technology

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“…This water-based HPCH solution forms a protective film that remineralizes and restructures nails, protects keratin, and maintains hydration. In clinical studies, it has been shown to reduce the signs of fragility and roughness in the nails of patients with psoriatic nail dystrophy (7)(8)(9). The HPCH-based nail solution is not intended as a cure for onychomycosis, as it does not exhibit antifungal activity; instead, it is able to form a film on the nail surface that may prevent fungal invasion.…”

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confidence: 99%

Ability of Hydroxypropyl Chitosan Nail Lacquer To Protect against Dermatophyte Nail Infection

Ghannoum

Long

Isham

et al. 2015

Antimicrob Agents Chemother

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The development of a topical agent that would strengthen the nail, improve the natural barrier, and provide better drug penetration to the nail bed is needed. In this study, we examined the effects of a hydroxypropyl chitosan (HPCH)-based nail solution using a bovine hoof model. Following application of the nail solution, changes in the hardness of the hoof samples were measured using the Vickers method. Tensile and flexural strengths were tested by stretching or punching the samples, respectively. The ultrastructure was examined using scanning electron microscopy (SEM), and samples stained with periodic acid-Schiff (PAS) stain were used to determine the fungal penetration depth. The comparators included 40% urea and 70% isopropyl alcohol solutions. The HPCH nail solution increased hoof sample hardness in comparison to the untreated control sample (

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“…In the literature, multiple treatments have been proposed, with topical and intralesional corticosteroids being the first line of choice [6], as it was done in the case of our patient who had infiltrations with triamcinolone but with a few response, probably due to the extensive involvement of the nail bed.…”

Section: Discussionmentioning

confidence: 99%

Ungueal Psoriasis: A Single Nail Affected

Me¹

2017

CDOAJ

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Improvement of psoriatic onychodystrophy by a water‐soluble nail lacquer

Abstract: In our experience, the new water-soluble nail lacquer proved to be effective in decreasing signs and symptoms of nail dystrophy in psoriatic patients. The effect was particularly evident on NAPSI and on pitting. The product was very well accepted by the patients.

Cited by 23 publications

References 5 publications

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

To what extent do in vitro tests correctly predict the in vivo residence of nail lacquers on the nail plate?

Ability of Hydroxypropyl Chitosan Nail Lacquer To Protect against Dermatophyte Nail Infection

Ungueal Psoriasis: A Single Nail Affected

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