Improvement of Quality of Life in Tacrolimus-Based Pediatric Renal Transplant Recipients and Their Caregivers, Including Donors

Hasegawa, Akira; Oshima, Satoshi; Takahashi, K; Uchida, Kazuharu; Ito, Katsuhiko; Sonoda, Takao

doi:10.1016/j.transproceed.2005.02.099

Cited by 20 publications

(18 citation statements)

References 3 publications

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“…However, our data did not show any significant correlation between the subscales physical complaints and dialysis prior to RTPL. Previous studies had shown that children and adolescents who had undergone transplantation had better physical and psychosocial health than did patients on dialysis [12,13], but there are no prospective studies analysing QOL in children on dialysis and after RTPL.…”

Section: Discussionmentioning

confidence: 99%

“…steroid-sensitive nephrotic syndrome, burn survivors, phenylketonuria or asthma [4][5][6][7]. There are only a few studies concerning QOL and PA in children and adolescents with chronic kidney disease [8], after RTPL [9][10][11][12] or both [13,14]. In 78 patients with chronic kidney disease aged 11 years to 18 years, a decline in renal function was associated with a subsequent impairment of QOL, particularly in terms of physical activity [8].…”

Section: Introductionmentioning

confidence: 99%

“…Qvist et al indicated a significantly lower QOL in children who had received transplants when under the age of 5 years [9]; after kidney or liver transplantation, adolescents reported concern about their body or health, less pleasure than ordinary adolescents and poor relationships with peers [10]. In comparison to before RTPL, QOL was significantly improved thereafter in 68 paediatric renal transplant recipients [12]. However, these studies differed in their methodology, and illness-related variables and psychosocial determinants of QOL were not systematically evaluated.…”

Section: Introductionmentioning

confidence: 99%

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Outcome after renal transplantation. Part II: Quality of life and psychosocial adjustment

et al. 2008

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Knowledge of health-related quality of life (QOL) and psychosocial adjustment (PA) in children after renal transplantation (RTPL) is limited. QOL and PA were evaluated by standardized tests in patients after RTPL. Thirty-seven children of median age 14.5 years (range 6.5-17 years) were investigated a mean 4.5 years (range 0.5-12.8 years) after RTPL. Child- and parent-rated QOL was evaluated with the Child Quality of life Questionnaire of The Netherlands Organization for Applied Scientific Research Academical Medical Centre (TNO-AZL). PA was assessed by the Child Behaviour Checklist (CBCL) providing parental reports of a child's behaviour. In patients' self-ratings, the QOL dimension physical complaints (P < 0.0005) scored significantly better than that of healthy controls, whereas the dimension positive emotional functioning was impaired (P = 0.02). Parents rated motor functioning (P = 0.002), autonomy (P = 0.01), cognition (P = 0.04) and positive emotions (P < 0.0005) as significantly impaired. Parents also assessed PA significantly (P = 0.02) impaired with regard to internalizing behaviour. Dialysis duration, young age at RTPL, living-related donation, steroid treatment, adverse family relationships and maternal distress had a significantly negative impact on QOL and PA (P < 0.05). Patients rated QOL higher than did healthy controls. Parents evaluated their children's QOL and PA more pessimistically than did the patients themselves. Both illness-related variables and family environment played an important role.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Outcome after renal transplantation. Part II: Quality of life and psychosocial adjustment

et al. 2008

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“…Fifty-seven studies met our review criteria and six were subsequently excluded (23)(24)(25)(26)(27)(28).…”

Section: Study Selectionmentioning

confidence: 99%

Psychosocial Health of Living Kidney Donors: A Systematic Review

Clemens

Thiessen‐Philbrook

Parikh

et al. 2006

American Journal of Transplantation

252

213

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Knowledge of the psychosocial benefits and harms faced by living kidney donors is necessary for informed consent and follow-up. We reviewed any English language study where psychosocial function was assessed using questionnaires in 10 or more donors after nephrectomy. We searched MEDLINE, EM-BASE, Web of Science, Psych INFO, Sociological Abstracts and CINAHL databases and reviewed reference lists from 1969 through July 2006. Independently, two reviewers abstracted data on study, donor and control group characteristics, psychosocial measurements and their outcomes. Fifty-one studies examined 5139 donors who were assessed an average of 4 years after nephrectomy. The majority experienced no depression (77-95%) or anxiety (86-94%), with questionnaire scores similar to controls. The majority reported no change or an improved relationship with their recipient (86-100%), spouse (82-98%), family members (83-100%) and nonrecipient children (95-100%). Some experienced an increase in self-esteem. A majority (83-93%) expressed no change in their attractiveness. Although many scored high on quality of life measures, some prospective studies described a decrease after donation. A small proportion of donors had adverse psychosocial outcomes. Most kidney donors experience no change or an improvement in their psychosocial health after donation. Harms may be minimized through careful selection and follow-up.

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“…A number of studies, mainly quantitative, have been carried out to investigate the physical and psychosocial wellbeing of children who have undergone transplantation. A few of these studies are from European countries (2, 3) and Japan (4) but most were conducted in the USA (5–7), each of which focused on a particular type of organ transplant. Quantitative quality of life studies have been carried out in the Nordic countries in children with cystic fibrosis, myelomeningocele and congenital heart defects (8–10).…”

mentioning

confidence: 99%

Transplanted children's experiences of daily living: Children's narratives about their lives following transplantation

Olausson

Utbult

Hansson

et al. 2006

Pediatric Transplantation

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Transplantation is often an appropriate choice of treatment for children with end-stage renal, liver, heart or lung disease. Over the last decade, mortality and morbidity figures have been relatively stable and quality of life fairly good in children who have undergone organ transplantation. Few studies however, have focused on the experiences of transplantation from the child's perspective. The child's view is an important factor when evaluating the 'true' outcome and quality of life after transplantation. The aim of the present study was to illuminate the meaning of transplanted children's experiences of daily living. Unstructured interviews were carried out with 18 children and adolescents, aged 4-18 yr, who had undergone organ transplantation. Their narratives were transcribed and interpreted using a phenomenologic-hermeneutic method inspired by the philosophy of Ricoeur. Two main themes emerged: Being satisfied with life, with the themes: being able to live a normal life; someone who cares; coping with one's new life; and being dissatisfied with life, with the themes: not being able to live a normal life; lacking someone who cares; not being respected; existential thoughts. Most of the children and adolescents were of the opinion that they lived a normal life while the rest strived to achieve a normal life. Social support and mental support were of great importance and, when lacking, had negative consequences. Multi-disciplinary co-operation between healthcare professionals and between the healthcare system, the school and the family is crucial in order to optimize the outcome and quality of life after organ transplantation in children.

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Improvement of Quality of Life in Tacrolimus-Based Pediatric Renal Transplant Recipients and Their Caregivers, Including Donors

Cited by 20 publications

References 3 publications

Outcome after renal transplantation. Part II: Quality of life and psychosocial adjustment

Outcome after renal transplantation. Part II: Quality of life and psychosocial adjustment

Psychosocial Health of Living Kidney Donors: A Systematic Review

Transplanted children's experiences of daily living: Children's narratives about their lives following transplantation

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