Improvement of right ventricular systolic performance by long-term domiciliary oxygen therapy in patients with chronic respiratory failure.

Effect of nocturnal oxygen and acetazolamide on exercise performance in patients with pre-capillary pulmonary hypertension and sleep-disturbed breathing: randomized, double-blind, cross-over trial

“…Supplemental oxygen has been shown to improve right ventricular function in patients with chronic obstructive pulmonary disease in association with a decreased pulmonary vascular resistance. 38,39 However, our study failed to show an improvement of the tricuspid valve systolic pressure gradient, as surrogate of pulmonary artery pressure. Possibly, the treatment period of 1 week was too short to improve several markers of right ventricular function and our study may have been underpowered to detect minor changes in some of the secondary outcomes.…”