“…CF could be affected by a wide number of both biotic and abiotic factors (e.g., drought, heat, flooding, temperature variation, parasitization, etc.) (Dong et al, 2020;Duarte et al, 2020;Zhou et al, 2020;Zhuang et al, 2020), which makes the evaluation of the mode of action of natural molecules quite impossible because of the overlapping of stressing conditions, which makes impossible to attribute the observed effects to the molecule assayed. Therefore, it is strongly suggested to perform experiments in completely controlled conditions using phytotrons and cropping plants hydroponically or on inert substrates enriched with nutrients and carbon sources (Graña et al, 2013b(Graña et al, , 2016Araniti et al, 2017c).…”