Improvement of sexual dysfunction in patients after treatment of hepatitis C virus using directly acting antivirals

Kassas, Mohamed El; Salah, Eman; gad, A.M.; Hosny, Ahmed

doi:10.1080/03007995.2021.1901677

Cited by 6 publications

(2 citation statements)

References 33 publications

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“…A recent study by El Kassas et al [21] demonstrated a significant improvement in HCV-associated sexual dysfunction in both sexes following HCV clearance with DAA treatment. To our knowledge, no prior studies have assessed the impact of these new drugs on semen parameters and sex hormone levels.…”

Section: Introductionmentioning

confidence: 97%

Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters

Mahmoud,

Eysa,

Ahmed

et al. 2024

Clin Exp Reprod Med

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Objective: Hepatitis C virus (HCV) infection is known to influence the seminal and hormonal parameters of infected men. This study was performed to assess the effects of HCV clearance using direct-acting antiviral (DAA) agents on semen and hormonal parameters. Methods: A total of 50 patients with chronic HCV were enrolled, and conventional semen analysis was performed according to World Health Organization guidelines. Basal levels of total testosterone, free testosterone (FT), follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol (E2), prolactin, and sex hormone-binding globulin (SHBG) were assessed before and 3 months after treatment with DAAs.Results: Following DAA treatment, statistically significant increases were observed in sperm motility and the proportion of grade A sperm. Additionally, the percentage of abnormal forms was significantly decreased after treatment (p=0.000). However, no significant differences were observed in semen volume, concentration, or total sperm count. Sex hormone analysis of patients after DAA treatment revealed significant increases in FT, LH, and FSH levels, along with significant decreases in SHBG, prolactin, and E2 levels.Conclusion: Following HCV clearance, we noted an improvement in sperm motility and an increase in the percentage of sperm with normal morphology. Treatment with DAAs was also associated with increased levels of FT and LH, along with decreased levels of SHBG, prolactin, and E2.

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Section: Introductionmentioning

confidence: 97%

Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters

Mahmoud,

Eysa,

Ahmed

et al. 2024

Clin Exp Reprod Med

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“…Both HIV and HCV infections can be controlled by prevention strategies, effective screening programs and access to treatments [16]. Since there are studies that have investigated sexual dysfunction, physical and physiological issues [9,17,18]. It became necessary to develop a quantitative questionnaire that assess SQoL in the context of HIV and HCV infections.…”

Section: Introductionmentioning

confidence: 99%

Positive relations between sexual quality of life and satisfaction with healthcare in women living with HIV and/or HCV: Results from a multicountry study

et al. 2023

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Introduction The sexual quality of life is a neglected concern in women living with HIV (WHIV) or with HCV (WHCV), which can further be affected by their experience with stigma, social instability, fear of transmission and reduced access to treatment. The objective of this study was to identify sociodemographic, psychosocial, and behavioural factors associated with sexual quality of life (SQoL) in this study group. Methods Between December 2017 and December 2018, PROQoL-Sex Life questionnaire was administered to 404 WHIV and WHCV in five countries. PROQoL-SQoL consists of four dimensions: positive sexual perception (Psp), stigma and social distress (Sti), soft sexual practices (Sof), sexual practices with a partner (Sp), all of which were scored from 0 to 100 and considered as main outcomes, lower scores mean better sexual quality of life. Linear mixed effects models were used to evaluate the association with sociodemographic and psychosocial factors. Results Of the participants analyzed, 191 were living with HCV, 180 with HIV and 33 with HIV and HCV, median age was 48. Among WHIV, a higher satisfaction with health care, and talking about sexuality with healthcare workers were associated with lower scores in all the dimensions of the SQoL, while psychoactive substance use was associated with lower scores of Sti and Sof. Moreover, higher satisfaction with health care, talking about sexuality with healthcare workers, and psychoactive substance use (except cocaine use) in WHCV were associated with lower scores in Psp, Sti, and Sof. Besides, cocaine use was associated with higher scores of Sof. Conclusion This study highlighted strong relationship between the quality of health care, and psychoactive substance use (except cocaine) and the sexual quality of life in WHIV and WHCV in these five countries. These findings draw attention to the different interventions that can be proposed for improving the sexual quality of life.

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Impact of Chronic Medical Disease on Sexual Function and Other Conditions

Sobel,

David

2024

Obstetrics and Gynecology Clinics of North America

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Improvement of sexual dysfunction in patients after treatment of hepatitis C virus using directly acting antivirals

Cited by 6 publications

References 33 publications

Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters

Effect of treatment of chronic hepatitis c virus patients with direct-acting anti-retroviral drugs on semen and hormonal parameters

Positive relations between sexual quality of life and satisfaction with healthcare in women living with HIV and/or HCV: Results from a multicountry study

Impact of Chronic Medical Disease on Sexual Function and Other Conditions

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