Improvement of Sexual Function in Male Patients After Parathyroidectomy for Secondary Hyperparathyroidism

Chou, Fong‐Fu; Lee, Chiang Hsuan; Shu, Kenneth; Yu, Tsan-Jung; Hsu, Kuo Tai; Sheen-Chen, Shyr Ming

doi:10.1016/s1072-7515(01)01060-2

Cited by 16 publications

(10 citation statements)

References 13 publications

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“…SHPT generally is associated with abnormally high rates of bone resorption and is often accompanied by pain and fractures (14 -16). Extraskeletal manifestations of the disease include vascular calcification, hypertension, anemia, pruritus, and sexual dysfunction (17)(18)(19)(20)(21)(22)(23)(24)(25). Analyses of data from large hemodialysis cohorts (1-3) have demonstrated significant relations among elevated PTH, Ca, and P and mortality and morbidity.…”

Section: Discussionmentioning

confidence: 99%

Cinacalcet Hydrochloride (Sensipar) in Hemodialysis Patients on Active Vitamin D Derivatives with Controlled PTH and Elevated Calcium × Phosphate

Chertow

Blumenthal

Turner

et al. 2006

Clinical Journal of the American Society of Nephrology

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Section: Discussionmentioning

confidence: 99%

Cinacalcet Hydrochloride (Sensipar) in Hemodialysis Patients on Active Vitamin D Derivatives with Controlled PTH and Elevated Calcium × Phosphate

Chertow

Blumenthal

Turner

et al. 2006

Clinical Journal of the American Society of Nephrology

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“…Most intriguingly, a series of 20 hemodialysis patients in Taiwan that underwent subtotal parathyroidectomy for hyperparathyroidism was found to have improved sexual function 3 months postoperatively. This was associated with unaltered testosterone levels but a reduction in PTH and prolactin (48). …”

Section: Ed In Ckdmentioning

confidence: 99%

Male Sexual Dysfunction and Chronic Kidney Disease

Edey

2017

Front. Med.

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Male sexual dysfunction is common in chronic kidney disease (CKD), particularly in end-stage renal disease. Historically, this cause of considerable morbidity has been under-reported and under-recognized. The ideal approach to diagnosis and management remains unclear due to a paucity of good quality data, but an understanding of the pathophysiology is necessary in order to address the burden of this important complication of CKD. This paper will review the endocrine dysfunction that occurs in renal disease, particularly the hypothalamic–pituitary–gonadal axis, discuss the causes of erectile dysfunction, infertility, and altered body image and libido in these patients and suggest appropriate treatment interventions.

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“…Researchers have recently reported an ED prevalence between 70% and 86% within this population [1][2][3][4][5][6]. Physiopathological risk factors related to renal disease, such as anemia, uremic neuropathy, hypogo-nadism, hyperprolactinemia, hyperparathyroidism, and atherosclerosis, have been widely studied [7][8][9][10][11][12]. Nevertheless, psychological risk factors for ED such as depression are controversial, despite the high prevalence of patients with depression undergoing hemodialysis (HD) [13][14][15].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Erectile Dysfunction on the Quality of Life of Men Undergoing Hemodialysis and Its Association with Depression

Vajgel

Santos

Soares

et al. 2010

The Journal of Sexual Medicine

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Introduction Erectile dysfunction (ED) is highly prevalent among men undergoing hemodialysis. Aim This study was performed to identify the influence of ED on the patient’s quality of life (QoL) and to evaluate the influence of depression on erectile function of these patients. Main Outcome Measures For this multicenter cross-sectional study, 275 patients were interviewed through questionnaires: the five-item version of the International Index of Erectile Function was used for diagnosing and classifying ED; the Medical Outcomes Study Questionnaire 36-Item Short Form Health Survey (SF-36) for scoring QoL; and the Hospital Anxiety and Depression Scale (HADS) to evaluate depressive symptoms. Linear regression was used to examine the associations between some of the variables and ED. Predialytic biochemical and hematological parameters were determined during the longer interdialytic period. Results Patients had a mean age of 48.6 ± 12.8 years, and the ED prevalence was 72.3%. Advanced age, diabetes and depression score were independent risk factors for the development of ED as confirmed by linear regression (P <0.001, P = 0.002, and P <0.001, respectively). QoL was worse among patients with any degree of ED, and the scores were statistically significant for overall health rating (P = 0.016), physical composite score (P = 0.003), bodily pain (P = 0.042), physical functioning (P <0.001), and vitality (P = 0.005). Furthermore, more severe forms of ED were associated with a lower QoL. After adjustment for some variables, such as age, time under dialysis, hemoglobin, albumin, parathyroid hormone, Kt/V, and depression, linear regression showed that domains related to poorer physical functioning (P = 0.047) and decreased vitality (P = 0.009) were significantly related to ED. Conclusion Depression is an important trigger for the development of ED in hemodialysis patients, and this sexual condition is an independent risk factor for their poor QoL.

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Improvement of Sexual Function in Male Patients After Parathyroidectomy for Secondary Hyperparathyroidism

Cited by 16 publications

References 13 publications

Cinacalcet Hydrochloride (Sensipar) in Hemodialysis Patients on Active Vitamin D Derivatives with Controlled PTH and Elevated Calcium × Phosphate

Cinacalcet Hydrochloride (Sensipar) in Hemodialysis Patients on Active Vitamin D Derivatives with Controlled PTH and Elevated Calcium × Phosphate

Male Sexual Dysfunction and Chronic Kidney Disease

The Impact of Erectile Dysfunction on the Quality of Life of Men Undergoing Hemodialysis and Its Association with Depression

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