Improvement of small intestinal microcirculation by postconditioning after lower limb ischemia

Turóczi, Zsolt; Fülöp, András; Czigány, Zoltán; Varga, Gabriella; Oliver, Roland; Tőkés, Tímea; Kaszaki, József; Lotz, Gábor; Harsányi, László; Szíjártó, Attila

doi:10.1016/j.mvr.2015.02.001

Cited by 4 publications

(2 citation statements)

References 42 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Anastomosists hypothesized intramural communication may exist between the opposing and the neighboring VR (antimesenteric and longitudinal intramural vascular anastomoses) [4][5][6][7][8] but the efficacy of these connections have never been measured. However, re-search on intestinal microcirculation and wound healing is very popular nowadays [9,10] The OPS technique is an accepted method of demonstrating microcirculation in vivo [11]. The velocity of the circulating RBCs, and the perfusion rate which can be accurately measured, are sensitive markers of the microcirculation.…”

Section: Introductionmentioning

confidence: 99%

Intestinal Intramural Vascular Anastomoses

Cervellione

Varga

Hajnal

et al. 2015

Journal of Investigative Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

Intestinal Intramural Vascular Anastomoses

Cervellione

Varga

Hajnal

et al. 2015

Journal of Investigative Surgery

Self Cite

View full text Add to dashboard Cite

show abstract

“…In recent years, cerebral ischemic PC has gradually gained attentions, although its mechanisms are not fully understood. Multiple mechanisms, such as improvement on microcirculation [36,37], inhibition of retinal cell apoptosis [38], and regulation of adenosine production [39], have been identified to be involved in the protective roles of PC. Diabetic retinopathy is a micro-vascular disease.…”

mentioning

confidence: 99%

Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia

Zhao

Liao

Zhang

et al. 2020

Journal of Diabetes Research

View full text Add to dashboard Cite

Ischemic postconditioning (PC) is proved to efficiently protect diabetic patients with acute myocardial infarction from ischemia-reperfusion injury. We aimed to explore the protective roles of ischemic PC on diabetic retinopathy in tree shrews with diabetic cerebral ischemia. A diabetic tree shrew model was established through high-fat diet feeding combined with streptozotocin (STZ) injection, while cortical thrombotic cerebral ischemia was induced photochemically. Tree shrews were divided into the normal control group, sham operation group, diabetes mellitus group, diabetes mellitus+cerebral ischemia group, and diabetes mellitus+cerebral ischemia+PC group (in which the tree shrews with diabetic cerebral ischemia were treated with ischemic PC). H&E staining was used to examine the pathological changes in the retina, and immunohistochemistry was performed to determine the retinal expression of VEGF (vascular endothelial growth factor). The modeling resulted in 77% tree shrews with diabetes. Ischemic PC reduced the blood glucose levels in the tree shrews with diabetic cerebral ischemia. Tree shrews with diabetes had thinned retina with disordered structures, and these pathological changes were aggravated after cerebral ischemia. The retinopathy was alleviated after ischemic PC. Retina expression of VEGF was mainly distributed in the ganglion cell layer in tree shrews. Diabetes and cerebral ischemia increased retinal VEGF expression in a step-wise manner, while additional ischemic PC reduced retinal VEGF expression. Therefore, ischemic PC effectively alleviates retinopathy in tree shrews with diabetic cerebral ischemia, and this effect is associated with reduced retinal VEGF expression.

show abstract

Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

László

Lázár

Brenner

et al. 2020

Biochemical Pharmacology

View full text Add to dashboard Cite

Improvement of small intestinal microcirculation by postconditioning after lower limb ischemia

Abstract: Microcirculatory impairment might be responsible for remote intestinal injury following infrarenal aortic occlusion. Postconditioning was able to reduce this remote intestinal damage.

Cited by 4 publications

References 42 publications

Intestinal Intramural Vascular Anastomoses

Intestinal Intramural Vascular Anastomoses

Ischemic Postconditioning Mitigates Retinopathy in Tree Shrews with Diabetic Cerebral Ischemia

Chronic treatment with rofecoxib but not ischemic preconditioning of the myocardium ameliorates early intestinal damage following cardiac ischemia/reperfusion injury in rats

Contact Info

Product

Resources

About