Improvement of Sperm Production in Subfertile Boars by<i>Cordyceps militaris</i>Supplement

Wang, Lin; Tsai, Meng-Chang; Chen, Yuh‐Shuen; Hou, Rolis Chien-Wei; Hung, H. H.; Li, Ching-Hsiao; Wang, Hsin‐Kai; Lai, Min-Nan; Jeng, Kee-Ching

doi:10.1142/s0192415x07005120

Cited by 34 publications

(18 citation statements)

References 25 publications

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“…This agrees with our previous report using a pig model (Lin et al, 2007). Importantly, we found that the increased serum testosterone concentrations during the CM supplementation paralleled with the changes of sperm motility in rats.…”

Section: Discussionsupporting

confidence: 93%

“…Supplementation with selenium and vitamin E also improved sperm quality in boars (Marin-Guzman et al, 1997; and vitamin E increased the concentration of spermatozoa in semen (Brezezinska-Slebodzinska et al, 1995). We recently reported that sperm production is enhanced significantly in adult pigs with supplementation with CM (Lin et al, 2007). However, the mechanism of this sperm enhancement effect is not clear.…”

Section: Introductionmentioning

confidence: 96%

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Effect ofCordyceps MilitarisSupplementation on Sperm Production, Sperm Motility and Hormones in Sprague-Dawley Rats

et al. 2008

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Cordyceps species have been traditionally used as for the enhancement of sexual function, but its direct evidence is lacking. We investigated the spermatogenic effect of Cordyceps militaris (CM) as supplementation with CM mycelium to 7-week-old male Sprague-Dawley (SD) rats. Ninety rats (30 for each group) were selected to regular diet or diet supplemented with CM mycelium (1% and 5%) for 6 weeks. Epididymal sperm were collected from 6 animals per group at each interval of observation. They were allowed to recover for one week. The quality and quantity of sperm were compared in these rats. The CM supplementation resulted in an increase of serum cordycepin concentration (n = 6, each group) that correlated with treatment time and the cordycepin level was significantly higher (p < 0.05) in 5% group as compared to 1% group at the 5th and 6th week. Epididymal sperm count was enhanced significantly from the control, at the 5th week and peaked at the 6th week in both groups supplemented with CM (each time point, n = 6; p < 0.05) and maintained for 2 weeks after stopping the treatment. Increased serum testosterone and estradiol-17 (E2) concentrations were found in rats with the CM supplementation (p < 0.05), but not other hormones such as follicle stimulating hormone (FSH), luteinizing hormone (LH) or prolactin. Importantly, percentages of motile sperm cells were also enhanced significantly (p < 0.05) paralleled the serum testosterone pattern from the supplement groups as compared to the control group. Taken together, these results indicate that supplementation with CM improves sperm quality and quantity in rats.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 96%

Effect ofCordyceps MilitarisSupplementation on Sperm Production, Sperm Motility and Hormones in Sprague-Dawley Rats

et al. 2008

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“…We determined that the serum testosterone concentration was increased in rats fed with the fruit bodies of CM. It was reported that the sperm production is enhanced significantly by supplementation with CM mycelium even to the subfertile adult pigs (Lin et al,2007). Our present result was in agreement with previous reports (Hsu et al, 2003;Huang et al, 2004;Chang et al, 2008).…”

Section: Change Of Testosterone Concentrationssupporting

confidence: 94%

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

Hong¹,

Choi²,

Woo³

et al. 2011

International Journal of Industrial Entomology

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Some of men have been suffered from the insufficient secretion of testosterone causing by physical factors, social and psychological factors. Testosterone is an essential steroid hormone controlling male reproductive function. Alternative medicines in plants, fungi, and insects have been studied to enhance sexuality. Cordyceps species including Cordyceps sinensis (CS) and C. militaris(CM) has been used as for the enhancement of sexual functionfor hundreds of years in Far East Asian. In the present study, we determined the effect of fruiting bodies of C. militaris which cultured on bee drone medium (CMD) and brown rice medium (CMB) on testosterone concentration in Sprague-Dawley rats. Eighteen rats per group were housed to regular diet or diet supplemented with CMB and CDD, respectively for 4 weeks. Serum was collected from 6 rats per group. Results showed that changes of the body weight, food and water intake of the rats were not observed in this study. However, both CMB and CDD increased the serum testosterone concentration in rats. Furthermore, CMD significantly stimulated testosterone production (p <0.05) compared to the control. Hence, it suggests that C. militaris fruiting bodymight be developed as a complementary medicine to improve sexual hormones.

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“…Cordycepin is not commercially available, and the authors anticipate that purification of this compound would be too expensive for it to be used as a feed additive. Using similar extract, Lin et al (2007) observed that CMF improved the sperm production in sub-fertile boars. In the current study, the data demonstrated that CMF increases bodyweight gain of piglets and decreases their feed conversion ratio.…”

Section: Discussionmentioning

confidence: 93%

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

Cheng¹,

Wen²,

Dybus³

et al. 2016

SA J. An. Sci.

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The aim of this study was to investigate the effect of supplementation of Cordyceps militaris fermentation products (CMF) on growth performance and immunocompetence of piglets. The study involved three groups of animals, which were supplemented with CMF (500, 1000 and 1500 μg/kg feed), and a control group. CMF supplementation significantly increased growth performance in weaned piglets. Bodyweight gain, average daily gain and feed intake in animals supplemented with 1000 µg CMF/kg feed were significantly higher in comparison with the control group. In addition, CMF supplementation only significantly increased the synthesis of Th1 cytokines, as indicated by the levels of IL-2 and IFN-γ. The piglets fed with the CMF supplement displayed an increased cellular immune response. Indeed, alveolar macrophages isolated from piglets supplemented with 1000 and 1500 µg CMF/kg feed had significantly higher chemotactic and phagocytic indices than those isolated from piglets that received the control feed or feed supplemented with 500 µg CMF/kg. In relation to the absence of effect on Th2 cytokines, the CMF supplement had no effect on hog cholera antibody titre. In summary, feed supplementation with CMF improves growth performance and enhances cell-mediated immunity. CMF supplementation may thus be useful at weaning to counteract physiological and immunological stress during this period. ______________________________________________________________________________________

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Improvement of Sperm Production in Subfertile Boars byCordyceps militarisSupplement

Cited by 34 publications

References 25 publications

Effect ofCordyceps MilitarisSupplementation on Sperm Production, Sperm Motility and Hormones in Sprague-Dawley Rats

Effect ofCordyceps MilitarisSupplementation on Sperm Production, Sperm Motility and Hormones in Sprague-Dawley Rats

Effect of Cordyceps militaris on Testosterone Production in Sprague-Dawley Rats

Fermentation products of <i>Cordyceps militaris</i> enhance performance and modulate immune response of weaned piglets

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