Improvement of stability and performance of functionalized halloysite nano tubes-based thin film nanocomposite membranes

Asempour, Farhad; Akbari, Somaye; Du, Bo; Emadzadeh, Daryoush; Matsuura, Takeshi; Kruczek, Boguslaw

doi:10.1016/j.memsci.2018.05.070

Cited by 69 publications

(38 citation statements)

References 38 publications

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“…The sharp peaks at 1100, 911, and 468 cm −1 can be assigned to bending vibrations of Si–O–Si, Al–O–H, and Al–O–H bands, respectively [ 75 , 78 ]. The surface functionalization of HNTs with CPS is confirmed by the appearance of the peak at 2939 cm −1 , which originates from stretching vibrations of C–H bonds of sp 3 carbon [ 79 , 80 ]. The elemental analysis based on EDX data further corroborates the results of FTIR spectroscopy.…”

Section: Resultsmentioning

confidence: 99%

Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy

et al. 2021

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Background Applied nanomaterials in targeted drug delivery have received increased attention due to tangible advantages, including enhanced cell adhesion and internalization, controlled targeted release, convenient detection in the body, enhanced biodegradation, etc. Furthermore, conjugation of the biologically active ingredients with the drug-containing nanocarriers (nanobioconjugates) has realized impressive opportunities in targeted therapy. Among diverse nanostructures, halloysite nanotubes (NHTs) with a rolled multilayer structure offer great possibilities for drug encapsulation and controlled release. The presence of a strong hydrogen bond network between the rolled HNT layers enables the controlled release of the encapsulated drug molecules through the modulation of hydrogen bonding either in acidic conditions or at higher temperatures. The latter can be conveniently achieved through the photothermal effect via the incorporation of plasmonic nanoparticles. Results The developed nanotherapeutic integrated natural halloysite nanotubes (HNTs) as a carrier; gold nanoparticles (AuNPs) for selective release; docetaxel (DTX) as a cytotoxic anticancer agent; human IgG1 sortilin 2D8-E3 monoclonal antibody (SORT) for selective targeting; and 3-chloropropyltrimethoxysilane as a linker for antibody attachment that also enhances the hydrophobicity of DTX@HNT/Au-SORT and minimizes DTX leaching in body’s internal environment. HNTs efficiently store DTX at room temperature and release it at higher temperatures via disruption of interlayer hydrogen bonding. The role of the physical expansion and disruption of the interlayer hydrogen bonding in HNTs for the controlled DTX release has been studied by dynamic light scattering (DLS), electron microscopy (EM), and differential scanning calorimetry (DSC) at different pH conditions. HNT interlayer bond disruption has been confirmed to take place at a much lower temperature (44 °C) at low pH vs. 88 °C, at neutral pH thus enabling the effective drug release by DTX@HNT/Au-SORT through plasmonic photothermal therapy (PPTT) by light interaction with localized plasmon resonance (LSPR) of AuNPs incorporated into the HNT pores. Conclusions Selective ovarian tumor targeting was accomplished, demonstrating practical efficiency of the designed nanocomposite therapeutic, DTX@HNT/Au-SORT. The antitumor activity of DTX@HNT/Au-SORT (apoptosis of 90 ± 0.3%) was confirmed by in vitro experiments using a caov-4 (ATCC HTB76) cell line (sortilin expression > 70%) that was successfully targeted by the sortilin 2D8-E3 mAb, tagged on the DTX@HNT/Au. Graphic abstract

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Section: Resultsmentioning

confidence: 99%

Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy

et al. 2021

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“…Outstandingly, WCA is practically independent of the number of layers and the displacement speed. The decrease in contact angle allows the increase in the permeability of the membranes . Membrane NF3 showed both WCA and PWP highest values; this apparent contradiction is explained considering that NF3 also exhibits the highest value of MWCO, which favors an increase in the PWP capacity (Table ).…”

Section: Resultsmentioning

confidence: 97%

Evaluation of a modified spray‐applied interfacial polymerization method for preparation of nanofiltration membranes

Morales‐Cuevas

Pérez‐Sicairos

Lin

et al. 2019

J of Applied Polymer Sci

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Nanofiltration (NF) membranes were fabricated by using piperazine (PIP) and trimesoyl chloride (TMC) by conventional and spray‐applied interfacial polymerization methods, studying the effect of the application method for both phases, the number of applied layers, and the displacement speed for the spray application. A polysulfone ultrafiltration membrane was used as support. NF membranes were characterized by different spectroscopic, microscopic, and physicochemical techniques. Rejection capacity was evaluated for sodium chloride (NaCl), sodium sulfate (Na2SO4), and magnesium sulfate (MgSO4) salts; the decreasing rejection order was Na2SO4 > MgSO4 > NaCl for each NF membrane. NF membrane prepared with one layer of the sprayed out TMC solution and conventional application of PIP solution exhibited the highest salt rejection (99% for 1000 ppm Na2SO4) and a permeated flux of 10.28 L m−2 h−1 at 0.55 MPa. The modified method is a facile‐reproducible preparation methodology that reduces the consumption of time, effort, and reagents leading to a scalable manufacturing process for separation technology. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 48129.

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“…It is because of hydrophilic amine functional groups present on the surface of HNTs after modification with APTES. 56 One of the challenging factors in wound healing is water vapor permeability of wound dressing, which is related to the prevention of wound dehydration. A higher amount of WVTR was measured indicated the more moisture the wound had lost.…”

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confidence: 99%

Engineered hemostatic bionanocomposite of poly(lactic acid) electrospun mat and amino‐modified halloysite for potential application in wound healing

Delyanee

Solouk

Akbari

et al. 2021

Polymers for Advanced Techs

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One of the essential characteristics of an ideal wound dressing is rapid hemostasis.This study aims to investigate the preparation and the characterization of electrospun poly(lactic acid) and halloysite nanotubes (PLA/HNTs) bionanocomposites with either different percentage of pristine and amino-modified HNTs (i.e., 5, 10, and 20 wt%).The effects of HNT's presence, amount, and modification are evaluated on the physicochemical and biological properties which are essential for hemostatic wound dressing. The energy dispersive spectroscopy indicates HNTs are well embedded and dispersed on PLA nanofibers to induce functional interfacial interactions. The addition of HNTs to the PLA in a concentration of 10 wt% improves moisture properties and increases the Young modulus of mats from 26.4 ± 1.66 to 31.62 ± 1.91 and 40.7 ± 1.99 MPa for pristine and modified HNTs, respectively. Also, the surface charge as an influential factor on hemostasis is increased from À39.1 ± 0.3 to À48.4 ± 0.5 and À43.6 ± 0.2 mV for PLA/pristine and modified HNTs bionanocomposites, respectively. Accordingly, blood clotting formation accelerated from 9 to 4 min for the bionanocomposite mat. Furthermore, biological evaluations show that bionanocomposites have suitable cell supporting. It seems that PLA/amino-modified HNTs bionanocomposite have potential application for hemostatic wound healing.

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Improvement of stability and performance of functionalized halloysite nano tubes-based thin film nanocomposite membranes

Cited by 69 publications

References 38 publications

Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy

Plasmonic photothermal release of docetaxel by gold nanoparticles incorporated onto halloysite nanotubes with conjugated 2D8-E3 antibodies for selective cancer therapy

Evaluation of a modified spray‐applied interfacial polymerization method for preparation of nanofiltration membranes

Engineered hemostatic bionanocomposite of poly(lactic acid) electrospun mat and amino‐modified halloysite for potential application in wound healing

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