Improvement of sticking tendency of granules during tabletting process by pressure swing granulation

Bakar, Noor Fitrah Abu; Mujumdar, Ajit; Urabe, Shun; Takano, Katsura; Nishii, Kazuo; Horio, Masayuki

doi:10.1016/j.powtec.2007.02.037

Cited by 8 publications

(17 citation statements)

References 24 publications

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“…The shape of the granules is spherical but it is not smooth on the surface. This might due to the size of the milled MA used in the granulation process that is slightly bigger than 5 µm whereby to have spherical and smoothness product granules, the size of the powder introduced in the fluidized bed must be less than 5 µm [6,13,14].…”

Section: Results and Discussion Scanning Electron Microscopymentioning

confidence: 99%

“…The graph shows the narrow size distribution because almost 80% of the granule size is less than 500 µm [6,13,14]. According to Takano et al [16], over 80% of the granules size must be in the range of 355 µm to 1410 µm for the preparation of pharmaceutical process.…”

Section: Figure 2 Sem Images Of (A) Lactose-ma Granules and (B) Lactmentioning

confidence: 99%

“…Granulation is often added as unit operation before the compaction step to enlarge particle size and to form spherical agglomerates [6,20] of the starting material but also to improve the mechanical properties under pressure [7,8]. Improvement of sticking tendency during tableting through granulation of APIs such as ibuprofen up to 70 wt.% with 30 wt.% lactose was successfully conducted through pressure swing granulation (PSG) technique in fluidized bed [6].…”

Section: Introductionmentioning

confidence: 99%

“…Improvement of sticking tendency during tableting through granulation of APIs such as ibuprofen up to 70 wt.% with 30 wt.% lactose was successfully conducted through pressure swing granulation (PSG) technique in fluidized bed [6].…”

Section: Introductionmentioning

confidence: 99%

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Granulation of Mefenamic Acid and Poly-Ethylene Glycol (Peg) Using Pressure Swing Granulation (Psg) Technique in Fluidized Bed

Salinda

Bakar²,

Bakar

et al. 2018

MJAS

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Granulation of mefenamic acid particles was conducted to produce spherical shape, narrow size distribution of granules, high granule strength and good content uniformity by using Pressure Swing Granulation (PSG) technique in a fluidized bed. Two types (binderless and with binder) of granules namely lactose-mefenamic acid (MA) and lactose-polyethylene glycol (PEG)-(MA) with mass ratio of 30:70 and 25:5:70 were produced respectively. The later type of granules was heated for 80 ˚C, above the PEG melting point. Results indicated that all granules were uniform, spherical and narrow size distribution with the average granules size was less than 500 μm. The tensile strength of the lactose-PEG-MA was higher than the lactose-MA due to heating process. The tensile strength of lactose-PEG-MA and lactose-MA with average granules size of 500 μm were 0.42 MPa and 0.33 MPa, respectively. The drug contents in both types of granules were uniform i.e. around 70 ± 0.3 wt.%.Keywords: mefenamic acid, lactose, polyethylene glycol, pressure swing granulation Abstrak Pembentukan granul zarah asid mefenamik telah dijalankan untuk menghasilkan bentuk bulat, taburan saiz granul yang kecil, kekuatan granul dan keseragaman kandungan yang baik dengan menggunakan teknik pengranulan terbendalir (PSG). Dua jenis granul (tanpa perekat dan dengan perekat) iaitu laktosa-asid mefenamik (MA) dan laktosa-polietilena glikol (PEG)-(MA) dengan nisbah jisim masing-masing adalah 30:70 dan 25:5:70. Granul kemudian dipanaskan pada 80 °C, melebihi takat lebur PEG. Keputusan menunjukkan bahawa semua granul yang terhasil adalah seragam, taburan saiz granul adalah sempit dengan saiz purata granul adalah kurang daripada 500 µm. Kekuatan tegangan laktosa-PEG-MA adalah lebih tinggi daripada laktosa-MA disebabkan oleh proses pemanasan semasa pengranulan. Kekuatan tegangan laktosa PEG-MA dan laktosa-MA dengan saiz granul purata 500 mikron masing-masing adalah 0.42 MPa dan 0.33 MPa. Kandungan MA dalam kedua-dua jenis granul adalah seragam iaitu sekitar peratusan jisim 70 ± 0.3 wt.%.

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Section: Results and Discussion Scanning Electron Microscopymentioning

confidence: 99%

Section: Figure 2 Sem Images Of (A) Lactose-ma Granules and (B) Lactmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Granulation of Mefenamic Acid and Poly-Ethylene Glycol (Peg) Using Pressure Swing Granulation (Psg) Technique in Fluidized Bed

Salinda

Bakar²,

Bakar

et al. 2018

MJAS

View full text Add to dashboard Cite

show abstract

“…Quantitative analysis using Raman Spectroscopy has increased over the past few years [6][7][8][9]. Moreover the use of Raman spectroscopy in tablets and powders mapping has increased as demonstrated by several industrial applications [10][11][12][13].…”

Section: Introductionmentioning

confidence: 99%

Using Raman spectroscopy in tablet moisture surface analysis: Tablet surface markers

Atef

Chauhan

Ceresia

et al. 2010

Journal of Pharmaceutical and Biomedical Analysis

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Applicability of UV laser-induced solid-state fluorescence spectroscopy for characterization of solid dosage forms

Woltmann

Meyer²,

Weigel

et al. 2014

Anal Bioanal Chem

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High production output of solid pharmaceutical formulations requires fast methods to ensure their quality. Likewise, fast analytical procedures are required in forensic sciences, for example at customs, to substantiate an initial suspicion. We here present the design and the optimization of an instrumental setup for rapid and non-invasive characterization of tablets by laser-induced fluorescence spectroscopy (with a UV-laser (λ ex = 266 nm) as excitation source) in reflection geometry. The setup was first validated with regard to repeatability, bleaching phenomena, and sensitivity. The effect on the spectra by the physical and chemical properties of the samples, e.g. their hardness, homogeneity, chemical composition, and granule grain size of the uncompressed material, using a series of tablets, manufactured in accordance with design of experiments, was investigated. Investigation of tablets with regard to homogeneity, especially, is extremely important in pharmaceutical production processes. We demonstrate that multiplicative scatter correction is an appropriate tool for data preprocessing of fluorescence spectra. Tablets with different physical and chemical characteristics can be discriminated well from their fluorescence spectra by subjecting the results to principal component analysis.

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Improvement of sticking tendency of granules during tabletting process by pressure swing granulation

Cited by 8 publications

References 24 publications

Granulation of Mefenamic Acid and Poly-Ethylene Glycol (Peg) Using Pressure Swing Granulation (Psg) Technique in Fluidized Bed

Granulation of Mefenamic Acid and Poly-Ethylene Glycol (Peg) Using Pressure Swing Granulation (Psg) Technique in Fluidized Bed

Using Raman spectroscopy in tablet moisture surface analysis: Tablet surface markers

Applicability of UV laser-induced solid-state fluorescence spectroscopy for characterization of solid dosage forms

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