2006
DOI: 10.1002/masy.200650821
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Improvement of Synthetic Vectors for Gene Therapy Using Ring‐Opening Cationic Polymerization

Abstract: Summary: For efficirent gene transfer, DNA has to be associated with a carrier which can be either of biological (i.e. recombinant viruses) or synthetic origin. In the domain of polymeric synthetic vectors two general types can be envisaged, namely positive polyelectrolytes or neutral amphiphilic block copolymers. Both types can be synthesized by ring-opening cationic polymerization. Several examples show that the versatility of this polymerization technique can be used for the design of structures which after… Show more

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Cited by 5 publications
(10 citation statements)
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“…Replacing the PPO block of Pluronics by a polytetrahydrofuran (pTHF) block reduced the toxicity 45. Cheradame et al synthesized triblock copolymers pMeOx‐ b ‐pTHF‐ b ‐pMeOx with a short hydrophobic block and suggested their potential for pDNA transfection 46,47. In vitro experiments were conducted, and the poor transfection efficiency were explained by the absence of interaction between DNA and the block copolymer.…”
Section: Introductionmentioning
confidence: 99%
See 1 more Smart Citation
“…Replacing the PPO block of Pluronics by a polytetrahydrofuran (pTHF) block reduced the toxicity 45. Cheradame et al synthesized triblock copolymers pMeOx‐ b ‐pTHF‐ b ‐pMeOx with a short hydrophobic block and suggested their potential for pDNA transfection 46,47. In vitro experiments were conducted, and the poor transfection efficiency were explained by the absence of interaction between DNA and the block copolymer.…”
Section: Introductionmentioning
confidence: 99%
“…[45] Cheradame et al synthesized triblock copolymers pMeOx-b-pTHF-b-pMeOx with a short hydrophobic block and suggested their potential for pDNA transfection. [46,47] In vitro experiments were conducted, and the poor transfection efficiency were explained by the absence of interaction between DNA and the block copolymer. Other nonionic amphiphilic block copolymers were developed: Reverse Pluronics PPO-b-PEO-b-PPO 25R2 was able to increase muscle transfection in a similar manner than P105 [48] and a combination between poly(ethylene glycol)-b-poly(lactic glycolic acid)-bpoly(ethylene glycol) (PEO 13 -b-PLGA 10 -b-PEO 13 ) and plasmid DNA provides the potential to improve gene delivery efficiency in rat skeletal muscles.…”
Section: Introductionmentioning
confidence: 99%
“…Fundamental research was carried out aiming at understanding relationships between their structure and their transfection efficiency, as well as their toxicity [4]. This research involved careful studies of polymer synthesis from the point of view of controlled architecture due to the need of high purity for these polymers to be used in physiological fluids [5] [6].…”
Section: Introductionmentioning
confidence: 99%
“…There is still a large place for structure optimization of these polymers of therapeutic interest and high added value. The synthesis by cationic ring opening polymerization of the triblock poly(ethylene oxide-b-tetrahydrofurane-b-ethylene oxide) on which the new more hydrophobic poly(tetrahydrofurane) sequence was replacing the central poly(propylene oxide) block of the above triblocks (poloxamer) allowed studying the in vivo transfection efficiency of this copolymer which was found to be approximately of the same efficiency as that of the one based on poly(propylene oxide) [5] [6].…”
Section: Introductionmentioning
confidence: 99%
“…This research involved careful studies of polymer synthesis from the point of view of controlled architecture due to the need of high purity for these polymers to be used in physiological fluids. [1,2] Two classes of polymers were under investigation, the positive polyelectrolytes and the neutral amphiphilic block copolymers.…”
Section: Introductionmentioning
confidence: 99%